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virB8 from Brucella suis 1330

Victor ID 964
Gene Name virB8 from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1164499
NCBI Protein GI 23499829
Locus Tag BRA0062
Protein Accession NP_699269.1
Other Database IDs UniProtKB-ID: VIRB8_BRUSU
UniRef100: UniRef100_Q2YJ78
UniRef90: UniRef90_Q2YJ78
UniRef50: UniRef50_Q2YJ78
UniParc: UPI000005830F
EMBL: AF141604
EMBL: AE014292
EMBL-CDS: AAD56618.1
EMBL-CDS: AAN33274.1
RefSeq_NT: NC_004311.2
PDB: 2BHM
GenomeReviews: AE014292_GR
KEGG: bms:BRA0062
TIGR: BRA0062
HOGENOM: HBG700868
OMA: LEMSDES
ProtClustDB: CLSK884263
BioCyc: BSUI204722:BR_A0062-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 59905
Gene Ending Position 60624
Gene Strand (Orientation) -
Protein Name type IV secretion system protein VirB8
DNA Sequence 
>gi|56968493:59905-60624 Brucella suis 1330 chromosome II, complete genome
TTCATTGCACCACTCCCATTTCTGGATCAACGCGATAGCTCGTGACATTGAAACCCAGCGGGTTTGTCAG
GCGGGCCGATTCCGACATCAAAGAGGGATTGACGTATTGGTAGCCAATGGTGGCGATCCAGTGCGTTGTT
TCGCCGTCACCGGTCTCGTTGGTGCGCTTTGTCGTCTTCGCAAAGCGCACCGTGCCGATGCCCTTGCCGT
TCGGCACGATGCTTACGATCGTTACCGATGTGCGCACATTTGAGCCATATTGCTTGTCAAGCGCCTTATC
GCCCTGGAACTGGCTTGCATAGCTCTGCCCTTCGGACGGCGACGACAACATGCCTACGGTTTCGTAGTCC
TTTTGCAGCGTGTACCAGTCGTAGGTTTCACGCGCTATCACGTACTGCGAGAGCCAGTATTTATCCATTA
CAGTGTCGTAGCTGACACTCTTCTCGTCGAGCGAGGTCAGGATATCAGGCGCACCTGTCTGTGCGTTGAC
GCGCACCAGGTAGGGCACATGTTGCTTTAGCGGTAACATCCCGGCGATGCCGATCCCGAGCAGCACGGTA
ATGGTGCCGAAAGCCCCGGCGATTTTCCACGCGCGGCGTTCGGATTTTTCGACCAGCCGGACGTGCGCGG
CCTCCCAGTTCAACGCTTCGTCATATACCGAAGGCGCATTGCCCTGCCCGTTCTTTACTGATTTCTGTGG
AGATTGTTTGCGTCCAAACA
Protein Sequence 
>gi|23499829|ref|NP_699269.1| type IV secretion system protein VirB8 [Brucella suis 1330] MFGRKQSPQKSVKNGQGNAPSVYDEALNWEAAHVRLVEKSERRAWKIAGAFGTITVLLGIGIAGMLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKYWLSQYVIARETYDWYTLQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSVTIVSIVPNGKGIGTVRFAKTTKRTNETGDGETTHWIATIGYQYVNPSLMSESARLTNPLGFNVTSYRVDPEMGVVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virB8 mutant was attenuated by a mini-Tn5 transposon mutagenesis (Gorvel and Moreno, 2002). Attenuated non-polar virB2, virB4, virB8, virB9 and virB10 Brucella mutants are capable of penetrating cells as the same rate as the virulent wild-type Brucella, transit through EEA1-positive early compartments and then localize in LAMP1-positive compartments at early times of infection (Gorvel and Moreno, 2002).
COG COG3736U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Gorvel and Moreno, 2002: Gorvel JP, Moreno E. Brucella intracellular life: from invasion to intracellular replication. Veterinary microbiology. 2002; 90(1-4); 281-297. [PubMed: 12414149].