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iucD from Shigella flexneri 2a str. 2457T

Victor ID 948
Gene Name iucD from Shigella flexneri 2a str. 2457T
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 2457T
NCBI Gene ID 1080259
NCBI Protein GI 30065049
Locus Tag S4053
Protein Accession NP_839220.1
Other Database IDs UniProtKB-ID: Q9XCH1_SHIFL
UniRef100: UniRef100_Q0SYK4
UniRef90: UniRef90_P11295
UniRef50: UniRef50_P11295
UniParc: UPI000000E790
EMBL: AF141323
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAD44749.1
EMBL-CDS: AAN45164.1
EMBL-CDS: AAP19031.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
EnsemblGenome: EBESCG00000087661.
EnsemblGenome_TRS: EBESCT00000088617
EnsemblGenome_PRO: EBESCP00000085439
EnsemblGenome: EBESCG00000090525.
EnsemblGenome_TRS: EBESCT00000091481
EnsemblGenome_PRO: EBESCP00000088117
Taxonomy ID 198215
Gene Starting Position 3948659
Gene Ending Position 3949996
Gene Strand (Orientation) -
Protein Name lysine:N6-hydroxylase
DNA Sequence 
>gi|30061571:3948659-3949996 Shigella flexneri 2a str. 2457T, complete genome
GTTATTCCTGAATATTTGCTGTATAGTGAGTTAAAGAAGCAGCCTCCGGCTGTGGTTTTTTCCGGCTGCC
GCTGCGCCACTGAATCAGTGCGGGCGGCATACTGAGATCGAATAAATCACGCCCCAGTACGCGATTAAGA
ATACGTGCAGATCGCCAGGCCATCAGGCTGAGCTGGGGTTCGGCGATGCCATGAGTTTGCATGCTGGCGT
TGACCGCAAAGATGTTATTTTCTTTCGGGCCACTCCATTCCAGAGTGAAGTCATCACGCACTTTAAAGGT
GTTCTTATCGTGCATGGTGATCAAGGGCATCAGTGAGGGAAGTATTTGTGGCAATGCAGAACGGTAACCT
GTGGCGAAAATCACCACATCACTTTCCAGGCTCTCTCTGCCCTGATCCAGATGATGTTCCATCAATAACC
TCCAGCCCGGACCACTACTTTCCAGAGTTGTTACCGAGCGACTGGGTAGCAGACGGATATTTCTTGGTTT
TCTCAGAACTTCAAAACGGTGGTACAACTCACGATAAATGGTCAGTAAAGAATCGGCAGTGATGCCATCC
GATGTCATTTTCTGCTCATCCAGTAACTGATGGCGAATATCTTCCTTCAGTCCGGAGAAGCCTGAAATAT
ATTCAGGTGTAAAATACTCATCAGCAAAAGCAGCCTCATCCAGTGCGTTAAAATTATTACGCCGTGAGAC
CCAGTTTATTTCCGCCGCTTCTCCCCATTCCCCGCGTAATGCATTAAGGAACAGGTCTGCACCACTCTGT
CCTCCACCAACCACGGTTATCCGTTTTCCACTCAGGTCCGGCCGACGAAGATTCATTTCACTGGCATGGA
AACAGGATTGTGTCACATGCTTCACACAGGGTGGTAAATAAGGTTGTTTTCCTGTACCAAGGCAGATATT
GTGGGCAAAATATTCTCCCCGACTGGTCTGAACCAGAAACAATCGACTTTTTTTGTCGAAATCAATATTT
TCAACGGTATGACTGAAATACAGGTTATTCATATCTTCAGCAGCCCAGCGGAGATAGTCAGAAAACTCTT
CACGGGATACTGTACGTAGCCTGCTTGTAAGGAAGCGATAGAACTTTTTGTGCTTCACCAGATAGTTAAC
AAAGCTGTAGGGATTTGTAGGTGCAACTGCACTGACCAGATCTTTCAGAAAGACGGTCTGCATATGACAA
TCCGGTACCAGCATACCCGGATGCCAGGAAAAATGAGGATGTTCGTCAAAGAAGAGACAGTTCAGTTCTT
CGATCTGATGTGACAATGCAGCAATGCTGAGATTAAATGGCCCTGTCCCGACACCAATAAAATCGACACT
TTTTTTCA
Protein Sequence 
>gi|30065049|ref|NP_839220.1| lysine:N6-hydroxylase [Shigella flexneri 2a str. 2457T] MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVKHVTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: iuc mutants are attenuated in chicken embryos and rabbit ileal loops (Wyckoff et al., 2009).
COG COG3486Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Wyckoff et al., 2009: Wyckoff EE, Boulette ML, Payne SM. Genetics and environmental regulation of Shigella iron transport systems. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2009; 22(1); 43-51. [PubMed: 19130265].