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dsbA from Shigella flexneri 2a str. 2457T

Victor ID 945
Gene Name dsbA from Shigella flexneri 2a str. 2457T
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 2457T
NCBI Gene ID 1080031
NCBI Protein GI 30064850
Locus Tag S3816
Protein Accession NP_839021.1
Other Database IDs UniProtKB-ID: DSBA_SHIFL
UniRef100: UniRef100_P52235
UniRef90: UniRef90_P0A4L6
UniRef50: UniRef50_P0A4L6
UniParc: UPI00001298C2
EMBL: D38253
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: BAA07407.1
EMBL-CDS: AAN45366.1
EMBL-CDS: AAP18832.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
PDB: 3DKS
EnsemblGenome: EBESCG00000085117
EnsemblGenome_TRS: EBESCT00000086072
EnsemblGenome_PRO: EBESCP00000082894
EnsemblGenome: EBESCG00000091028
EnsemblGenome_TRS: EBESCT00000091984
EnsemblGenome_PRO: EBESCP00000088
Taxonomy ID 198215
Gene Starting Position 3716487
Gene Ending Position 3717113
Gene Strand (Orientation) -
Protein Name periplasmic protein disulfide isomerase I
DNA Sequence 
>gi|30061571:3716487-3717113 Shigella flexneri 2a str. 2457T, complete genome
ATTATTTTTCCTCGGACAGATATTTCACCGTATCAGCATACTGCTGAACAAAAACATCCATATTGCTGGT
ATCCATACCCTGCGGATTCAGCTGATATTTACCGTTAACAAACATCGCCGGAACACCACGCAATTGCACA
TCAGCTGCGGCTTTTTCCTGCTGAGCGACCAGAGATTTCACCACGAAGCTGTTCCACGCCGCGTCGTACT
CTTCACCTTTAATACCTGCATTGATAAATACATCGCGGATATCAGATGCTGAACGAATGGTCTGGGTTTT
CTGTACGCCTTCAAACAGCGGAACAGTCACTTTGTCTTCCACGCCCAGCGCCATCGCCACAGCCCATGCC
TGAGTCAGATCTTTGCCCAGGTCACCACCCATGAAGTTGACGTGGTATTTAGTCATCTTCACGCCTTCCG
GCAGTTTTTTCTTCACATTATCAGAAATATGCAGAACTTCTTCAAACTGATAGCAGTGCGGGCAGAAGAA
AGAGAAAAACTCCAGCACTTGCGGCGCGCCAGCTACCGGTTTTTCCAGGGTAGTGTACTGTTTACCATCT
TCATACTGCGCCGCCGATGCGCTAAACGCTAAAACTAAACCAGCCAGCGCCAGCCAAATCTTTTTCA
Protein Sequence 
>gi|30064850|ref|NP_839021.1| periplasmic protein disulfide isomerase I [Shigella flexneri 2a str. 2457T] MKKIWLALAGLVLAFSASAAQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNFMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: dsbA mutants are less invasive to MK-2 cell monolayers compared to the wild-type (Watarai et al., 1995).
COG COG1651O, under O: Posttranslational modification, protein turnover, chaperones
References
Watarai et al., 1995: Watarai M, Tobe T, Yoshikawa M, Sasakawa C. Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1995; 92(11); 4927-4931. [PubMed: 7761426].