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sigA from Shigella flexneri 2a str. 2457T

Victor ID 943
Gene Name sigA from Shigella flexneri 2a str. 2457T
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 2457T
NCBI Gene ID 1079436
NCBI Protein GI 30064291
Locus Tag S4824
Protein Accession NP_838462.1
Other Database IDs UniProtKB-ID: Q83JR2_SHIFL
UniRef100: UniRef100_B7LBY5
UniRef90: UniRef90_B7LBY5
UniRef50: UniRef50_Q31TN1
UniParc: UPI000000E5A2
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAN44449.1
EMBL-CDS: AAP18272.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
MEROPS: S06.010
EnsemblGenome: EBESCG00000086674.
EnsemblGenome_TRS: EBESCT00000087629
EnsemblGenome_PRO: EBESCP00000084451
EnsemblGenome: EBESCG00000089604.
EnsemblGenome_TRS: EBESCT00000090560
EnsemblGenome_PRO: EBESCP00000087196
GenomeReviews: AE005
Taxonomy ID 198215
Gene Starting Position 3052613
Gene Ending Position 3056470
Gene Strand (Orientation) +
Protein Name serine protease
DNA Sequence 
>gi|30061571:3052613-3056470 Shigella flexneri 2a str. 2457T, complete genome
TATGAATAAAATTTATTCACTGAAATATAGTCATATTACAGGTGGATTAGTTGCTGTTTCTGAACTGACC
CGGAAAGTTAGTGTCGGTACATCAAGAAAGAAAGTTATCCTCGGTATTATTTTATCCTCAATATATGGAA
GTTATGGCGAAACAGCATTTGCAGCAATGCTGGATATAAATAATATATGGACCCGCGATTATCTTGACCT
TGCTCAAAACAGAGGAGAGTTCAGACCGGGTGCAACAAATGTTCAATTAATGATGAAAGATGGAAAGATA
TTTCATTTTCCAGAACTACCTGTACCTGATTTTTCTGCTGTTTCCAACAAAGGTGCAACAACATCAATTG
GAGGTGCGTACAGTGTTACTGCGACTCATAACGGTACACAGCATCATGCAATAACAACACAGTCATGGGA
TCAGACAGCATATAAAGCAAGTAACAGAGTATCATCTGGCGACTTTTCGGTTCATCGTCTGAATAAATTC
GTCGTGGAAACAACAGGGGTTACGGAGAGTGCCGACTTCTCACTTTCTCCCGAAGATGCGATGAAAAGAT
ATGGCGTAAACTACAACGGTAAGGAACAAATAATTGGCTTCAGAGCAGGTGCCGGAACAACCTCAACGAT
ATTAAACGGCAAACAATATCTGTTTGGACAAAACTATAATCCCGACTTGTTAAGCGCAAGTCTTTTTAAT
CTGGACTGGAAAAACAAGAGTTACATTTATACCAACAGAACCCCTTTTAAAAACTCACCAATTTTTGGCG
ATAGTGGTTCTGGTTCTTATCTATATGATAAAGAACAACAAAAATGGGTTTTCCATGGTGTTACCAGTAC
AGTTGGTTTTATCAGTAGTACCAATATAGCCTGGACAAACTACTCGTTATTTAATAATATTCTGGTAAAC
AATTTAAAAAAGAATTTCACAAACACTATGCAGCTGGATGGTAAAAAACAAGAGTTATCATCGATTATAA
AAGATAAGGACCTGTCTGTCTCAGGAGGAGGGGTATTAACGCTCAAGCAGGATACCGATCTTGGCATTGG
CGGGCTTATATTCGATAAGAACCAGACATATAAAGTGTACGGAAAAGATAAGTCTTATAAAGGTGCCGGG
ATAGATATTGATAATAATACCACCGTTGAATGGAATGTTAAGGGCGTTGCCGGAGATAATCTGCATAAAA
TAGGTAGTGGTACTCTGGATGTAAAAATAGCACAGGGAAATAACCTTAAAATAGGTAATGGGACTGTCAT
CCTTAGTGCTGAAAAAGCCTTCAATAAAATTTACATGGCCGGAGGTAAAGGTACGGTAAAAATAAATGCC
AAAGACGCTTTAAGCGAAAGCGGTAATGGCGAAATCTATTTTACCAGAAATGGCGGAACACTGGATCTAA
ACGGCTATGACCAGTCATTTCAGAAAATCGCAGCAACAGATGCGGGAACAACCGTAACGAACTCAAACGT
GAAGCAATCAACATTATCACTTACTAATACTGATGCATATATGTACCATGGGAATGTATCAGGTAATATA
AGCATAAATCATATTATCAATACTACCCAGCAACATAACAATAATGCCAATCTGATCTTTGATGGCTCAG
TCGATATCAAAAACGATATCTCTGTCCGGAATGCACAGTTAACATTACAAGGACATGCGACAGAACATGC
CATATTTAAAGAAGGCAATAACAACTGTCCAATTCCTTTTTTATGTCAAAAAGACTATTCTGCTGCCATA
AAGGACCAGGAAAGCACTGTAAATAAACGTTACAATACGGAATATAAGTCCAACAATCAGATAGCCTCTT
TTTCCCAGCCCGACTGGGAAAGTCGTAAATTTAATTTCCGGAAATTAAATTTAGAAAACGCAACCCTGAG
TATAGGCCGGGATGCTAATGTAAAAGGACACATAGAGGCTAAAAACTCTCAAATTGTTCTGGGAAATAAA
ACTGCATACATTGACATGTTCTCAGGAAGAAACATTACTGGCGAAGGTTTTGGATTCAGACAACAGCTTC
GCTCCGGGGATTCAGCAGGCGAAAGTAGTTTCAACGGCAGTCTGAGTGCTCAAAACAGCAAAATAACTGT
TGGTGATAAATCAACTGTTACTATGACTGGTGCATTATCCTTAATTAATACAGACCTGATTATCAACAAA
GGAGCTACTGTTACCGCCCAGGGAAAAATGTATGTAGATAAAGCTATTGAACTGGCCGGAACCCTGACAT
TAACAGGCACCCCTACAGAAAATAATAAATACAGCCCGGCAATCTATATGTCAGATGGATATAATATGAC
AGAAGATGGTGCCACGTTAAAGGCTCAAAATTATGCCTGGGTCAATGGTAATATAAAATCAGACAAAAAA
GCATCTATTCTGTTTGGTGTTGACCAGTATAAAGAAGATAACCTGGACAAAACCACACACACACCGCTGG
CTACAGGTTTGCTGGGTGGCTTTGATACTTCTTATACCGGAGGTATTGATGCTCCTGCAGCCTCAGCCAG
CATGTATAACACCTTATGGAGAGTAAACGGACAGTCAGCCCTGCAATCATTAAAAACCCGCGACAGTCTT
TTGTTGTTTAGTAACATAGAGAATTCGGGTTTCCATACTGTGACAGTAAACACACTGGATGCCACTAATA
CTGCTGTGATTATGCGGGCTGATCTGAGCCAGTCTGTAAATCAATCGGATAAACTCATTGTTAAAAATCA
GTTAACCGGAAGCAATAACAGTCTGTCGGTCGATATACAGAAAGTGGGAAATAATAACTCAGGATTAAAC
GTTGACCTGATAACAGCCCCAAAAGGAAGCAATAAAGAGATATTTAAAGCCAGTACTCAGGCCATAGGTT
TCAGCAACATATCTCCTGTGATCAGCACGAAAGAGGATCAGGAACATACCACGTGGACCCTGACCGGATA
TAAGGTGGCTGAAAATACAGCATCTTCCGGTGCAGCAAAATCGTATATGTCCGGTAATTACAAAGCCTTC
CTGACAGAAGTCAACAACCTGAATAAACGAATGGGGGATCTGCGTGACACCAATGGCGAGGCCGGTGCAT
GGGCCCGCATCATGAGCGGAGCAGGTTCAGCTTCTGGTGGATACAGTGACAACTACACCCATGTGCAGAT
TGGTGTGGATAAAAAACATGAGCTGGATGGACTTGACCTTTTCACTGGTCTGACTATGACGTATACCGAC
AGTCATGCCAGCAGTAATGCATTCAGTGGCAAGACGAAGTCCGTCGGGGCAGGTCTGTATGCTTCCGCTA
TATTTGACTCTGGTGCCTATATCGACCTGATTAGTAAGTATGTTCACCATGATAATGAGTACTCGGCGAC
CTTTGCTGGACTCGGAACAAAAGACTACAGTTCTCATTCCTTGTATGTGGGTGCTGAAGCAGGCTACCGC
TATCATGTAACAGAAGACTCCTGGATTGAGCCGCAGGCAGAACTGGTTTATGGGGCCGTATCAGGTAAAC
GGTTCGACTGGCAGGATCGCGGAATGAGCGTGACCATGAAGGATAAGGACTTTAATCCGCTGATTGGGCG
TACCGGTGTTGATGTGGGTAAATCCTTCTCCGGTAAGGACTGGAAAGTCACAGCCCGCGCCGGCCTTGGC
TACCAGTTTGACCTGTTTGCCAACGGTGAAACCGTACTGCGTGATGCGTCCGGTGAGAAACGTATCAAAG
GTGAAAAAGACGGTCGTATTCTCATGAATGTTGGTCTCAACGCCGAAATTCGCGATAATCTTCGCTTCGG
TCTTGAGTTTGAGAAATCGGCATTTGGTAAATACAACGTGGATAACGCGATCAACGCCAACTTCCGTTAC
TCTTTCTG
Protein Sequence 
>gi|30064291|ref|NP_838462.1| serine protease [Shigella flexneri 2a str. 2457T] MNKIYSLKYSHITGGLVAVSELTRKVSVGTSRKKVILGIILSSIYGSYGETAFAAMLDINNIWTRDYLDLAQNRGEFRPGATNVQLMMKDGKIFHFPELPVPDFSAVSNKGATTSIGGAYSVTATHNGTQHHAITTQSWDQTAYKASNRVSSGDFSVHRLNKFVVETTGVTESADFSLSPEDAMKRYGVNYNGKEQIIGFRAGAGTTSTILNGKQYLFGQNYNPDLLSASLFNLDWKNKSYIYTNRTPFKNSPIFGDSGSGSYLYDKEQQKWVFHGVTSTVGFISSTNIAWTNYSLFNNILVNNLKKNFTNTMQLDGKKQELSSIIKDKDLSVSGGGVLTLKQDTDLGIGGLIFDKNQTYKVYGKDKSYKGAGIDIDNNTTVEWNVKGVAGDNLHKIGSGTLDVKIAQGNNLKIGNGTVILSAEKAFNKIYMAGGKGTVKINAKDALSESGNGEIYFTRNGGTLDLNGYDQSFQKIAATDAGTTVTNSNVKQSTLSLTNTDAYMYHGNVSGNISINHIINTTQQHNNNANLIFDGSVDIKNDISVRNAQLTLQGHATEHAIFKEGNNNCPIPFLCQKDYSAAIKDQESTVNKRYNTEYKSNNQIASFSQPDWESRKFNFRKLNLENATLSIGRDANVKGHIEAKNSQIVLGNKTAYIDMFSGRNITGEGFGFRQQLRSGDSAGESSFNGSLSAQNSKITVGDKSTVTMTGALSLINTDLIINKGATVTAQGKMYVDKAIELAGTLTLTGTPTENNKYSPAIYMSDGYNMTEDGATLKAQNYAWVNGNIKSDKKASILFGVDQYKEDNLDKTTHTPLATGLLGGFDTSYTGGIDAPAASASMYNTLWRVNGQSALQSLKTRDSLLLFSNIENSGFHTVTVNTLDATNTAVIMRADLSQSVNQSDKLIVKNQLTGSNNSLSVDIQKVGNNNSGLNVDLITAPKGSNKEIFKASTQAIGFSNISPVISTKEDQEHTTWTLTGYKVAENTASSGAAKSYMSGNYKAFLTEVNNLNKRMGDLRDTNGEAGAWARIMSGAGSASGGYSDNYTHVQIGVDKKHELDGLDLFTGLTMTYTDSHASSNAFSGKTKSVGAGLYASAIFDSGAYIDLISKYVHHDNEYSATFAGLGTKDYSSHSLYVGAEAGYRYHVTEDSWIEPQAELVYGAVSGKRFDWQDRGMSVTMKDKDFNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLFANGETVLRDASGEKRIKGEKDGRILMNVGLNAEIRDNLRFGLEFEKSAFGKYNVDNAINANFRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigA mutant is attenuated in rabbit ileal loop infection model (Al-Hasani et al., 2000).
COG COG4625S, under S: Function unknown
References
Al-Hasani et al., 2000: Al-Hasani K, Henderson IR, Sakellaris H, Rajakumar K, Grant T, Nataro JP, Robins-Browne R, Adler B. The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation. Infection and immunity. 2000; 68(5); 2457-2463. [PubMed: 10768931].