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guaA from Shigella flexneri 2a str. 2457T

Victor ID 940
Gene Name guaA from Shigella flexneri 2a str. 2457T
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 2457T
NCBI Gene ID 1078991
NCBI Protein GI 30063899
Locus Tag S2725
Protein Accession NP_838070.1
Other Database IDs UniProtKB-ID: GUAA_SHIFL
UniRef100: UniRef100_Q83QL1
UniRef90: UniRef90_A7ZPV1
UniRef50: UniRef50_Q3JR65
UniParc: UPI000000E489
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAN44053.1
EMBL-CDS: AAP17880.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
EnsemblGenome: EBESCG00000086756
EnsemblGenome_TRS: EBESCT00000087711
EnsemblGenome_PRO: EBESCP00000084533
EnsemblGenome: EBESCG00000089306
EnsemblGenome_TRS: EBESCT00000090262
EnsemblGenome_PRO: EBESCP00000086898
GenomeReviews: AE005674_GR
GenomeReviews
Taxonomy ID 198215
Gene Starting Position 2613998
Gene Ending Position 2615575
Gene Strand (Orientation) -
Protein Name bifunctional GMP synthase/glutamine amidotransferase protein
DNA Sequence 
>gi|30061571:2613998-2615575 Shigella flexneri 2a str. 2457T, complete genome
ATCATTCCCACTCAATGGTAGCTGGCGGCTTGCCGCTGATGTCATACACCACGCGGGAAATACCGTTCAC
TTCATTGATAATGCGGTTGGAAACGCGACCGAGGAAATCGTACGGCAGATGCGCCCAGTGTGCGGTCATA
AAGTCGATGGTTTCGACAGCACGCAGAGAGACAACCCAGTCATACTTACGACCATCGCCCATTACGCCAA
CGGAACGTACTGGCAGGAAGACGGTGAACGCCTGGCTGACTTTGTCGTACAGGTCCGCTTTACGCAGTTC
TTCAATGAAGATGGCGTCAGCACGGCGCAGCAGGTCACAGTACTCTTTCTTCACTTCACCCAGAACACGA
ACGCCAAGGCCTGGTCCCGGGAACGGATGACGGTACAGCATGTCGTACGGCAGGCCCAGCTCCAGACCAA
TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAGGCCCATCTTCATCTCTTTCGGCAG
GCCGCCCACGTTGTGGTGAGATTTGATGACGTGTGCTTTACCGGTTGCAGAAGCCGCAGATTCGATAACG
TCAGGGTAGATGGTGCCCTGCGCCAGCCACTTCACGTCTTCCAGTTTCAGCGCTTCTTCATCGAATACTT
CAACGAAAACGCGCCCGATGATTTTACGTTTTGCTTCCGGATCGTTTTCGCCAGCCAGCGCTGACAGGAA
GCGATCTTCTGCCGGTACGTGAACAATGTTAAGACCAAAGTGATCGCCAAACATATCCAGAACCTGCTCT
GCTTCGTTGAGACGCAGCAGGCCGTTGTCGACGAATACGCAAGTCAGGTTTTTACCGATAGCACGGTGCA
GCAGCATTGCGGTTACGGAGGAATCCACACCACCAGAGAGGCCGAGGATGACTTTATCGTCGCCTACCTG
CTCGCGGATGCGAGCTACAGCATCGTCGATAATTTTCGCTGGCGTCCACAGGGCTTCACACTGGCAGATA
TCACGCACAAAACGCTCCAGCATGCGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACGC
CATAGAAGCGTTTTTCTTCGTTAGCCATAATGGCAAACGGGCAGCTTTCGGTGCTGGCTACGGTGACGAA
GTCGGACGGGATAGCGGTAACTTTATCGCCGTGGCTCATCCAGACATCGAGCAGCGGTTTACCGTCTGCG
GTCAGCGCATCTTCGATACCGCGAACCAGTGCGCTGTCGTTTACGACTTCTACCTGCGCGTAGCCAAATT
CACGTTCGTTAGAGGCTTCAACGTGACCGCCCAACTGCATTGCCATGGTCTGCATGCCATAGCAAACGCC
GAATATCGGTACGCCTGCTTCAAAGACATACTGCGGCGCACGCGGACTGTTTTCTTCAGTAGTACTTTCC
GGGCCGCCGGAAAGAATAATTCCGCTTGGATTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC
ACAGTTCGCAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC
CAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence 
>gi|30063899|ref|NP_838070.1| GMP synthase [Shigella flexneri 2a str. 2457T] MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPIFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaAguaB mutants are attenuated in HeLa cells (Noriega et al., 1996).
COG COG0519F, under F: Nucleotide transport and metabolism
References
Noriega et al., 1996: Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infection and immunity. 1996; 64(8); 3055-3061. [PubMed: 8757833].