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phoP from Shigella flexneri 2a str. 2457T

Victor ID 931
Gene Name phoP from Shigella flexneri 2a str. 2457T
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 2457T
NCBI Gene ID 1077630
NCBI Protein GI 30062677
Locus Tag S1232
Protein Accession NP_836848.1
Other Database IDs UniProtKB-ID: PHOP_SHIFL
UniRef100: UniRef100_Q8CXZ9
UniRef90: UniRef90_Q57QC3
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI000000E0F8
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAN42766.1
EMBL-CDS: AAP16655.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
EnsemblGenome: EBESCG00000084846
EnsemblGenome_TRS: EBESCT00000085801
EnsemblGenome_PRO: EBESCP00000082623
EnsemblGenome: EBESCG00000091936
EnsemblGenome_TRS: EBESCT00000092892
EnsemblGenome_PRO: EBESCP00000089528
GenomeReviews: AE005674_GR
GenomeReviews
Taxonomy ID 198215
Gene Starting Position 1193852
Gene Ending Position 1194523
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|30061571:1193852-1194523 Shigella flexneri 2a str. 2457T, complete genome
ATCAGCGCAATTCGAACAGGTAGCCCTGGCCGCGAACGGTGGTAATGACTTCTTGCGGATATTGTGCCTG
AATTTTTTTGCGCAGACGTCCCATCAGTACATCAATGGTATGGCTTTCCCGCAGCTCCGCATCCGGATAG
AGTTGTAGCATTAACGAATCTTTGCTGACCACTTTGCCATTATTGCGTATCAACGTTTCCATAATGGTGT
ATTCGAACGCGGTCAGTTTGATCACTTCGTCATTAATAGATAATTCACGGCGAGAGAGATCAACCTGAAA
CGGGGGGAGCGAAATGACCTGTGAAGCCAGACCGCTATTACGCCGCATTAATGCCTGCATTCGCGCCATC
ACCTCTTCAATATGAAACGGTTTAGTCACGTAATCATCAGCACCGGCACTTAATACTTCGACTTTGTCCT
GCCAGCTTTCACGGGCGGTTAATACCAGAATCGGCAGTGAAACATCGTTGCTACGCCAGCGGCGAATCAG
TGACAGACCGTCCTCGTCAGGCAATCCGAGATCGACAATCGCAATATCCGGTAAATGTTCATTGAGATAA
TAATCGGCTTCTTTGGCATCTTCTGCGTCATCGACCTGATGACCAGCATCCTGAATCTGAACTTTAAGGT
GGTGACGTAACAACGCATTGTCTTCAACAACCAGTACGCGCA
Protein Sequence 
>gi|30062677|ref|NP_836848.1| DNA-binding transcriptional regulator PhoP [Shigella flexneri 2a str. 2457T] MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants were resolved more quickly than wild type in animal models, and are more susceptible to killing by PMNs (Moss et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Moss et al., 2000: Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular microbiology. 2000; 2(6); 443-452. [PubMed: 11207599].