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phoN2/apy

Victor ID 921
Gene Name phoN2/apy
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238061
NCBI Protein GI 31983594
Locus Tag CP0004
Protein Accession NP_858137.1
Other Database IDs UniProtKB-ID: Q59909_SHIFL
UniRef100: UniRef100_D2AJ47
UniRef90: UniRef90_Q93IG8
UniRef50: UniRef50_Q93IG8
UniParc: UPI00000BEF6A
EMBL: U04539
EMBL: AF386526
EMBL-CDS: AAA21206.1
EMBL-CDS: AAL72358.1
RefSeq_NT: NC_004851.1
HSSP: Q9S1A6
EnsemblGenome: EBESCG00000093052.
EnsemblGenome_TRS: EBESCT00000094008
EnsemblGenome_PRO: EBESCP00000090215
GenomeReviews: AF386526_GR
KEGG: sfl:CP0004
HOGENOM: HBG509560
OMA: DEKMAIT
ProtClustDB: CLSK504961
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 2370
Gene Ending Position 3110
Gene Strand (Orientation) +
Protein Name PhoN2 (Apy), periplasmic phosphatase, apyrase, ATP diphosphohydrolase
DNA Sequence 
>gi|31983523:2370-3110 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TATGAAAACCAAAAACTTTCTTCTTTTTTGTATTGCTACAAATATGATTTTTATCCCCTCAGCAAATGCT
CTGAAGGCAGAAGGTTTTCTCACTCAACAAACTTCACCAGACAGTTTGTCAATACTTCCGCCGCCTCCGG
CAGAGAATTCAGTAGTATTTCAGGCTGACAAAGCTCATTATGAATTCGGCCGCTCGCTCCGGGATGCTAA
TCGTGTACGTCTCGCTAGCGAAGATGCATACTACGAGAATTTTGGTCTTGCATTTTCAGATGCTTATGGC
ATGGATATTTCAAGGGAAAATACCCCAATCTTATATCAGTTGTTAACACAAGTACTACAGGATAGCCATG
ATTACGCCGTGCGTAACGCCAAAGAATATTATAAAAGAGTTCGTCCATTCGTTATTTATAAAGACGCAAC
CTGTACACCTGATAAAGATGAGAAAATGGCTATCACTGGCTCTTATCCCTCTGGTCATGCATCCTTTGGT
TGGGCAGTAGCACTGATACTTGCGGAGATTAATCCTCAACGTAAAGCGGAAATACTTCGACGTGGATATG
AGTTTGGAGAAAGTCGGGTCATCTGCGGTGCGCATTGGCAAAGCGATGTAGAGGCTGGGCGTTTAATGGG
AGCATCGGTTGTTGCAGTACTTCATAATACACCTGAATTTACCAAAAGCCTTAGCGAAGCCAAAAAAGAG
TTTGAAGAATTAAATACTCCTACCAATGAACTGACCCCATA
Protein Sequence 
>gi|31983594|ref|NP_858137.1| PhoN2 (Apy), periplasmic phosphatase, apyrase, ATP diphosphohydrolase [Shigella flexneri 2a str. 301] MKTKNFLLFCIATNMIFIPSANALKAEGFLTQQTSPDSLSILPPPPAENSVVFQADKAHYEFGRSLRDANRVRLASEDAYYENFGLAFSDAYGMDISRENTPILYQLLTQVLQDSHDYAVRNAKEYYKRVRPFVIYKDATCTPDKDEKMAITGSYPSGHASFGWAVALILAEINPQRKAEILRRGYEFGESRVICGAHWQSDVEAGRLMGASVVAVLHNTPEFTKSLSEAKKEFEELNTPTNELTP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoN2/apy mutant is attenuated for growth in HeLa and Caco-2 cells (Santapaola et al., 2006).
COG COG0671I, under I: Lipid transport and metabolism
References
Santapaola et al., 2006: Santapaola D, Del Chierico F, Petrucca A, Uzzau S, Casalino M, Colonna B, Sessa R, Berlutti F, Nicoletti M. Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread. Journal of bacteriology. 2006; 188(4); 1620-1627. [PubMed: 16452446].