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ipaA from Shigella flexneri 2a str. 301

Victor ID 919
Gene Name ipaA from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238056
NCBI Protein GI 31983589
Locus Tag CP0125
Protein Accession NP_858258.1
Other Database IDs UniProtKB-ID: IPAA_SHIFL
UniRef100: UniRef100_P18010
UniRef90: UniRef90_P18010
UniRef50: UniRef50_P18010
UniParc: UPI000012D7D0
EMBL: X17628
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL: J04117
EMBL-CDS: CAA35624.1
EMBL-CDS: CAC05800.1
EMBL-CDS: AAK18443.1
EMBL-CDS: AAL72353.1
EMBL-CDS: AAA26525.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 2GDC
PDB: 2GWW
PDB: 2HSQ
PDB: 2IBF
MINT: MINT-6174234
EnsemblGenome: EBESCG00000093043
EnsemblGenome_TRS: EBESCT00000093999
EnsemblGenome_PRO: EB
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 107177
Gene Ending Position 109078
Gene Strand (Orientation) -
Protein Name IpaA, secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|31983523:107177-109078 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TTTAATCCTTATTGATATTCTTTAATACTTTTGATAGGGAAGTGGTTACATCTTTTGCTGCTTTATATAT
ATTATTGTTTTCAGCTGTAATATCATTGTTATTTTTTAAATCAGATATATCATCTGTAAGTAATTCTGCA
GAGGTATCGTCAATTTTTGACAATACCTTGCTGAGGGCGCTAGATACTTCTTTTGCCTTTTCATAGATCG
CATGATTTTTATCAATTGTATCTGCGTTGGTTTCTGTTACGTAGTTTCTTATATTTGCATCTGTAACTTT
TAATTTGTTGTTTATTCTATGTTCTGTTGTGGATTTTGTAATGTCCTTTGATTTTTCCTGTAACTCTCGT
TCTTGTGTTCCTGATTTAGTTCCAATGAGAGATATAAGATTACTTAGGGAGTTTGTTACTTTTTTTGAAG
CTTCAAATATCGTTTCCCGTGTTAAATATGTGTCTCCATTTCTTGATAAAAAATCAGTCTGAAGTACTTT
TGAATCAGTGTTTGAGTTGAATTTATTGATTTGCGAAGCTACTCTATGAGAAAGAGAAGCGCTACTTTTA
GTTGTATCTGATGAGTTATCATTACTGCTTGTCACTCCTTCCGGGTGGAGAGGGGGGGTGGTTGAAGAGT
TCTGTATGTTCAGAGGCCTGTGTCCCCGAGAAAGAGAGTTATTTGCAGATCTTTCTTGACTACTCGTAGT
TAACAGGTCTGAACCTATTCCATCCGAATTATCTGGAGTATGGTTGAAAGCCTTTTCTAAAGCTGAATTA
TTTGCAAATGTCTGGACAGTATCTGATATAGAGTGTGGTAGAACGGAAGTTACTTTTTGAACTAGTGCTC
TTTGTGGATTTAGTAATGAGTTTCCGTTACGGGATAATAGATCGTTTGTCTGAGAAGTAGGAGACTGTGC
ATCATTTTCTGGGTTCTCGTGATAGCTATTGTCATATACTCTGTTGTCAAAAACTCTATTATCGTAAGTT
CTATTATCATTATTTATATGATAGTGAATTACAGGTTGGGATGTTTTCTCATTGGCTCCGGGGGTTGGTC
CGCCATCTGGCATATCTTCGGGAGGTGTAGGGAGGCCATCTTGGATAGGATGCGAATCTTTTATATCTTC
TAAAATATCATTAAGGACTTTTCTCAACAGCTCAGGAAACACGGCTACTGTATTTAAGTCTCTTGACAGT
TTACCTATACCAAATCCTTTACTATCAATAGTATTTTTACGTTGATTGCGCAAACTATCAAAGGCAAGTT
TTGCCTGTGCGTCAACTAAATCATCTAGTTTGAGAGATGAAACAGTTTCATTACTTAACTTTAATTCAGC
AAGAATATTATTCTTGATAAATGATGATACTTCAGTATTGAGGAGTTTTTGTCCCAATGATAAAGCTTCA
CCAGATGTGTGTTGTTGTGCTAATAGTGCAAGTCTGTGCTCAATGTTTTGTCGTAATTGATGGAGTTTCT
TATTCTTTGCCGACCATGGTCCAAAGGCAGAATCTTGGGATAATTTATCTTTTATAATTAGTTCCGAATA
CTGTGCGACAATTTTTTGAAGTCCCTTTTCGTTTTCAAAATTAAGACCATTTTGATGTACTAAGGAGTAC
AAAACATTTGAAAATTCGAGAATCTCGCTTTTGGCATACGCATTCATTGAGTTGGAATAAATGCTTCTTA
ACACATCTTCTTTCCCTGAGGAAGAAAATAAAAAATCAAGACATTTCTGATTAAAAGACGTTGCAAAGTT
TTCTTTTTCAGACACTGATGCTGGTGTTTTTAGAGAAGTTTGCGAACTATGGATATCGGATATTTTGCTT
TTTAACTCGCTGTATTCTGTTGATGATGGTGAAGTTGCCTTATATAAGAATGTTGGCGCTTGAGTATTAT
TTACATTATGCA
Protein Sequence 
>gi|31983589|ref|NP_858258.1| hypothetical protein CP0125 [Shigella flexneri 2a str. 301] MHNVNNTQAPTFLYKATSPSSTEYSELKSKISDIHSSQTSLKTPASVSEKENFATSFNQKCLDFLFSSSGKEDVLRSIYSNSMNAYAKSEILEFSNVLYSLVHQNGLNFENEKGLQKIVAQYSELIIKDKLSQDSAFGPWSAKNKKLHQLRQNIEHRLALLAQQHTSGEALSLGQKLLNTEVSSFIKNNILAELKLSNETVSSLKLDDLVDAQAKLAFDSLRNQRKNTIDSKGFGIGKLSRDLNTVAVFPELLRKVLNDILEDIKDSHPIQDGLPTPPEDMPDGGPTPGANEKTSQPVIHYHINNDNRTYDNRVFDNRVYDNSYHENPENDAQSPTSQTNDLLSRNGNSLLNPQRALVQKVTSVLPHSISDTVQTFANNSALEKAFNHTPDNSDGIGSDLLTTSSQERSANNSLSRGHRPLNIQNSSTTPPLHPEGVTSSNDNSSDTTKSSASLSHRVASQINKFNSNTDSKVLQTDFLSRNGDTYLTRETIFEASKKVTNSLSNLISLIGTKSGTQERELQEKSKDITKSTTEHRINNKLKVTDANIRNYVTETNADTIDKNHAIYEKAKEVSSALSKVLSKIDDTSAELLTDDISDLKNNNDITAENNNIYKAAKDVTTSLSKVLKNINKD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaA mutants are attenuated in invasion of HeLa cells (Tran et al., 1997).
References
Tran et al., 1997: Tran Van Nhieu G, Ben-Ze'ev A, Sansonetti PJ. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. The EMBO journal. 1997; 16(10); 2717-2729. [PubMed: 9184218].