Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ipaB from Shigella flexneri 2a str. 301

Victor ID 918
Gene Name ipaB from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238055
NCBI Protein GI 31983588
Locus Tag CP0128
Protein Accession NP_858261.1
Other Database IDs UniProtKB-ID: IPAB_SHIFL
UniRef100: UniRef100_P18011
UniRef90: UniRef90_Q03945
UniRef50: UniRef50_P18011
UniParc: UPI000012D7D2
EMBL: J04117
EMBL: M34849
EMBL: AL391753
EMBL: AF348706
EMBL: X15319
EMBL: AF386526
EMBL-CDS: AAA26522.1
EMBL-CDS: AAA98424.1
EMBL-CDS: CAC05803.1
EMBL-CDS: AAK18446.1
EMBL-CDS: CAA33381.1
EMBL-CDS: AAL72352.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 3GZ1
PDB: 3GZ2
EnsemblGenome: EBESCG00000093197
EnsemblGenome_TRS: EBESCT00000094153
EnsemblGenome_PRO: EBESCP0
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 111247
Gene Ending Position 112989
Gene Strand (Orientation) -
Protein Name IpaB, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
DNA Sequence 
>gi|31983523:111247-112989 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
ATCAAGCAGTAGTTTGTTGCAAAATTGCTTTTGCAACATCAGTTCTATTAGCCTGAGAGTTGGACATTGA
GGCTAATAGATCTGCAATTACTTCCTGCAATTGGCCGAATTTTTCTATTGCTTCACTGATATATTTTGAC
AGTTGTTCAACTTGATATTTCGATAATGTCAGGTCTGCTAGATTTGTCGACGCGCTGTTCTGGAAAACAG
CAGAAGCGACACTTCCTCCCGCTTGTGTGGCAGAGTTAACACTTTCTCCTAATAAAACTGCTTGGTTTAA
ATGGGTGGAAATAATTTGTTTGGATATTACTTCATCACCCGCTGCACCAAGAAATTTATTTAATCTGGCA
ACAGCATTAGTGATTAAATCGTCCAGTTGAGAAGAAAAATTCTTGAGAAACTTTGGTATAAGGTCTGTGA
GGGTTTTACCTATTATTTTGCCAATATTTTCTGCAAGTTTTGCTGCTGCCTGTTTACCAACAGTGGCTAC
GAGAACGACTGCTGCAACTAGGACAAGAGCGCCTGCGATTGCCCCCAGAATAGAGCCAATCATTTTGGCT
TTTTTCGAGTCGACGCCCAAGCCTTCGAGCATTTTTGTAAATGCATCTGAAAGGAGTTTGATTAAGGGTT
CAATGACTGCTTTCATGATCGGATTCAGGGCTTGTTCCATGAAGGAATTGCCGGTCGCTGCTTGTACTAT
AGCATCCGTAACCATAAGAGCTAAACCAACAGCTGCCAGTGCTAGAGAGGCTCCTCCAGAAAAAGCTGCT
GCAACAACACTAACGATAGTTAAAAGTGCCCCAAGTATTTTCCCAACACAACCCATTACTCTGTTGAGTT
CTTCTGCTTTACGTACTTCAGCAGCATACTCATCAGATTTTCTCTCCATTTCAGTTTTTCTTGATTCTTG
GAGAGACTGGAATAGAGCCAGATCATTTTTTAAAGATTCTTCATTATTTTTTCCAACTAGTTGAATAAAG
GTTGCCATCAATTGAGTAACACTGGCAAGTCCGGTTAATGATTTCTGCTGGGTTGATAGCTGTTCAGCAG
ATGCTGTGTTTGAAAATGCAGAAAAAGAGTCTATTTCTTTTTCGAGTTGCATTGATTTATCTGTAAGTTT
GCTATGAATTGACAGGGTTTTCTGCTCAATCAATGTCCTGTCTTTAACTGCTGCGTCTTTTTTGATAGTG
AGTTGTATTTCTTCCCGGCTTAATTTTTTCTTTTCTGGTGACTCTGGGTCGAGTTCGGATAATCTTGTTT
GAATTTGGTTAATTTTATTTTCTAGGTCTTTTATTTTAGAATCTGCGTTTTTTAGTTTATTAATTTGTTT
TTCATAGTCTCTGGTTAGTCCTTCAGTTTCAGATAGAAGAGTGTTAATTTTATCGGAGAATTCTAGGTTT
TTTTGCTGTCTTGCCTGTTGCTGGGACTTCCAAGCAGTAATTTTATTTGTTAATGCAGTTAAAGATTTTT
CACCGAGTATTTGAATAAGGTTTCCAATTAAAAGCGTTAGTTGGGAACTTGCATTTAATGACTTTGGTGC
TTTAAGTTCAGGGATTAATATATTTGAAGTTGAGTGTGCATTAGTTGTATTAATATTTTGGTTAGCAGTA
AGATCAGCAATTGTAAGAGAAAATAATTTGTTAGCTGCATCATTTGCAGCTTGGATAGTATTGTCTCCAA
GCTCAGTGGAAGCCAATATTTTGGCAAGAGGAAAACCAGTGGTTGTGGTGCTTACATTATGCA
Protein Sequence 
>gi|31983588|ref|NP_858261.1| IpaB, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [Shigella flexneri 2a str. 301] MHNVSTTTTGFPLAKILASTELGDNTIQAANDAANKLFSLTIADLTANQNINTTNAHSTSNILIPELKAPKSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQTRLSELDPESPEKKKLSREEIQLTIKKDAAVKDRTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGKILGALLTIVSVVAAAFSGGASLALAAVGLALMVTDAIVQAATGNSFMEQALNPIMKAVIEPLIKLLSDAFTKMLEGLGVDSKKAKMIGSILGAIAGALVLVAAVVLVATVGKQAAAKLAENIGKIIGKTLTDLIPKFLKNFSSQLDDLITNAVARLNKFLGAAGDEVISKQIISTHLNQAVLLGESVNSATQAGGSVASAVFQNSASTNLADLTLSKYQVEQLSKYISEAIEKFGQLQEVIADLLASMSNSQANRTDVAKAILQQTTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaB mutant is unable to infect HeLa cells (Roehrich et al., 2010).
COG COG2433S, under S: Function unknown
References
Roehrich et al., 2010: Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK. The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infection and immunity. 2010; 78(4); 1682-1691. [PubMed: 20086081].