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ipaC from Shigella flexneri 2a str. 301

Victor ID 917
Gene Name ipaC from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238054
NCBI Protein GI 56404015
Locus Tag CP0127
Protein Accession NP_858260.2
Other Database IDs UniProtKB-ID: IPAC_SHIFL
UniRef100: UniRef100_P18012
UniRef90: UniRef90_Q03946
UniRef50: UniRef50_P18012
UniParc: UPI00001700EE
EMBL: J04117
EMBL: M34849
EMBL: AL391753
EMBL: AF348706
EMBL: X15319
EMBL: AF386526
EMBL-CDS: AAA26523.1
EMBL-CDS: AAA98425.1
EMBL-CDS: CAC05802.1
EMBL-CDS: AAK18445.1
EMBL-CDS: CAA33382.1
EMBL-CDS: AAL72351.2
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093252
EnsemblGenome_TRS: EBESCT00000094208
EnsemblGenome_PRO: EBESCP00000090415
GenomeReviews: AF386526_GR
KEGG:
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 110136
Gene Ending Position 111227
Gene Strand (Orientation) -
Protein Name IpaC, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
DNA Sequence 
>gi|31983523:110136-111227 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
ATTAAGCTCGAATGTTACCAGCAATCTGACTGGCTGTCGAATTCTTTGATTGGTTGATGCTGTCAATTAT
ATTCAATAATTTTTGTATTAATTGATTTGTCGCTTGGGATGCTTCTTTAGATACTTGGGATGCTTCCTCT
GCTTGTTTACTGCTGGCCTGACTGATTAGTTGTTCTTCTTCTTCAAGAGCAGATGCATAACGCCCTCCTG
ATGTGGATATATTACCAGCAACGGCTGATGTTTCCATTGTTGCACGGCCAATGTTTTGTTTTTGCTGCGC
AGAAAGGGTATTGAGCTCGTAAGTTCTTCTCTGGGTGTCAATTTTATCCTGCAAAGAAATATCGGGAGAA
CTAAGAGAAGTTTTATGTTCAGTTGACAGGGATATATTATCTGGCGCCAGTTTATTTTTACCTAAAAATT
TTGTGCTAGAGTTAGTTTGTGGTGAGGTGATATTTGTATCTATTTGTTTATTTAACCCTAATTTAGAACC
TGCAAGCTCTTTTTCAAGAGATTGAGCAGTGGCAAGGTTCTTTCTTAAGGCTCCTTTTTGGTCGCTAATC
CCTGAATGCGTTTTTTTGGCACCGATACCCGTTATACCTACTTGTGTGACTGCTCCAGTAATGCTTGATG
ATAGGGCTGCCAGGCCTTGCCGAACAATGTTCTCTGCAGCTGATTTTGTAGCATCGAACGCAATCAATGA
CAATTGAGAGCCCAATTTAGTTTCTGCAGTGCGGAGAGCAGAAAGTAGAACGGCTACACTAATAATTAAA
GAAACAGCATTAGAAGAAAGACTGGAAATATCCAGAGTGTTCTCTGGAGTAAGGGTGTGACTCATCTCTG
AACGATCTTTCATCTTTTTGTCAGTAAGGCGAGCAATGATTTCTGAATCATGCTGAACCTGCTCTGATAA
CTTTAAAAGTTGATCATCATTTAATGTGGTTGTTAATACGGGATTTTTACCGACATTAAGTGGAATATGC
GCTGCAATCTGCTGATAATTTTGTGATTTTTGTGTTTCGGAAGAACTTTGAGTTTGTTTTGTGGATATAT
CTGTATATAAAATCTGGGTTGGTTTTGTGTTTTGAATTTCCA
Protein Sequence 
>gi|56404015|ref|NP_858260.2| IpaC, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [Shigella flexneri 2a str. 301] MEIQNTKPTQILYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLTTTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDRSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRTYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDSINQSKNSTASQIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaC mutants cannot invade cultured cells or lyse red blood cells (Terry et al., 2008).
References
Terry et al., 2008: Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD. The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells. Microbial pathogenesis. 2008; 45(4); 282-289. [PubMed: 18656530].