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ipaD from Shigella flexneri 2a str. 301

Victor ID 916
Gene Name ipaD from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238053
NCBI Protein GI 31983586
Locus Tag CP0126
Protein Accession NP_858259.1
Other Database IDs UniProtKB-ID: IPAD_SHIFL
UniRef100: UniRef100_P18013
UniRef90: UniRef90_Q03947
UniRef50: UniRef50_Q03947
UniParc: UPI000012D7D6
EMBL: J04117
EMBL: X15319
EMBL: AL391753
EMBL: AF348706
EMBL: AY206439
EMBL: AF386526
EMBL: M34849
EMBL-CDS: AAA26524.1
EMBL-CDS: CAA33383.1
EMBL-CDS: CAC05801.1
EMBL-CDS: AAK18444.1
EMBL-CDS: AAP78989.1
EMBL-CDS: AAL72350.1
EMBL-CDS: AAA98426.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 2J0N
PDB: 2J0O
PDB: 2JAA
TCDB: 1.C.36.3.1
EnsemblGenome: EBESCG00000093166
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 109087
Gene Ending Position 110085
Gene Strand (Orientation) -
Protein Name IpaD, secreted by the Mxi-Spa machinery, required for entry of bacteria into epithelial cells
DNA Sequence 
>gi|31983523:109087-110085 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
CTCAGAAATGGAGAAAAAGTTTATCTGTATCTGTACATGAGCTTATTGTACTACTCAAAACCTTTACTAA
ATTATCAAAAATACTATTGGCATTACTGTATTTTTGAACTAAAGTTTGAAGATTATTTTTCATTGTTTCA
TCTTCGGCAGAGAATCCGGCATTCCATGCCTGATATTTTGCATTATCTAGCACAACCTCGCCATTTCCAC
CTAGATTATCTAAGCTTTTTAACATATTGTCTATTGGGGTCATGTTTATACTGACAACATATCCCCCGTT
TTTTTGAGATACCTTGCCGATTGTTCCACCTAATTCTGTAAGCCATTTATTTGCTTGTTCCTGACTAACA
GTATTATTTGCTGGATATAGCGGTTTATCTTTATATTTTTCCTTGAGTTCTTCCAATGCCTTTTTAAGCG
AGTTGACTTGTAATTTCACGGAGTTTCCGTCGTTACCTCCGGGAGAGATCCAGCCGGCAAGACTGGAAAG
AACAGCGCTAAAATCTTGATACATTTGAGTATATGAACTAACGGCATGTTCATATACTTTCAGATACTGT
TCATTAATATCATTGATGGAGTTTGCAATTTTAGCCCACAGTTCTCTATGAGATATCATTTGATCTCCAT
CAAGCTCGGCTTCTTTCGGAGCTGAATGTAATAATTCTCTTGCGTCTTTATTAATTGGATATTCGTGCCT
GGAAAGAATATCCAATAGTTGAGCGGATTTATTTACATCCATGCTAATCTGAGATGAATGTAATGCTATT
TCTTCTAGCGATGTTTTAGTCAACGTTTTTTGTGAAAGCTCTTTCTTTAATGCCTGATTTGTTGTTCTGA
TATTATGAAGGGTGTCGTTGAGCATAGTAAGGGAACTTACAGGATGAGAACTGGTCGTTGTTTTTATATC
AGAATTAACTGTTTCGGTTGATGAACCGTTGGTATTGTTTGGACTGAATGATGAGGTGGAAATACTATTA
GTCAGAGTTGTTATATTCA
Protein Sequence 
>gi|31983586|ref|NP_858259.1| hypothetical protein CP0126 [Shigella flexneri 2a str. 301] MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKELSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSRHEYPINKDARELLHSAPKEAELDGDQMISHRELWAKIANSINDINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVNSLKKALEELKEKYKDKPLYPANNTVSQEQANKWLTELGGTIGKVSQKNGGYVVSINMTPIDNMLKSLDNLGGNGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFLHF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaD mutants are completely unable to invade cultured cells or lyse RBCs (Picking et al., 2005).
References
Picking et al., 2005: Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infection and immunity. 2005; 73(3); 1432-1440. [PubMed: 15731041].