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ipaH7.8 from Shigella flexneri 2a str. 301

Victor ID 915
Gene Name ipaH7.8 from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238049
NCBI Protein GI 31983582
Locus Tag CP0078
Protein Accession NP_858211.1
Other Database IDs UniProtKB-ID: IPA7_SHIFL
UniRef100: UniRef100_P18014
UniRef90: UniRef90_P18014
UniRef50: UniRef50_Q31SH3
UniParc: UPI00000BEF77
EMBL: AF386526
EMBL: AF348706
EMBL: AY879342
EMBL: AL391753
EMBL: M32063
EMBL-CDS: AAL72346.1
EMBL-CDS: AAK18394.1
EMBL-CDS: AAW64892.1
EMBL-CDS: CAC05787.1
EMBL-CDS: AAA26526.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093145
EnsemblGenome_TRS: EBESCT00000094101
EnsemblGenome_PRO: EBESCP00000090308
GenomeReviews: AF386526_GR
KEGG: sfl:CP00
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 62213
Gene Ending Position 63910
Gene Strand (Orientation) +
Protein Name invasion plasmid antigen, probably secreted by the Mxi-Spa machinery
DNA Sequence 
>gi|31983523:62213-63910 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TATGTTCTCTGTAAATAATACACACTCATCAGTTTCTTGCTCCCCCTCTATTAACTCAAACTCAACCAGT
AATGAACATTATCTGAGAATCCTGACTGAATGGGAAAAGAACTCTTCTCCCGGGGAAGAGCGAGGCATTG
CTTTTAACAGACTCTCCCAGTGCTTTCAGAATCAAGAAGCAGTATTAAATTTATCAGACCTAAATTTGAC
GTCTCTTCCCGAATTACCAAAGCATATTTCTGCTTTGATTGTAGAAAATAATAAATTAACATCATTGCCA
AAGCTGCCTGCATTTCTTAAAGAACTTAATGCTGATAATAACAGGCTTTCTGTGATACCAGAACTTCCTG
AGTCATTAACAACTTTAAGTGTTCGTTCTAATCAACTGGAAAACCTTCCTGTTTTGCCAAACCATTTAAC
ATCATTATTTGTTGAAAATAACAGGCTATATAACTTACCGGCTCTTCCCGAAAAATTGAAATTTTTACAT
GTTTATTATAACAGGCTGACAACATTACCCGACTTACCGGATAAACTGGAAATTCTCTGTGCTCAGCGCA
ATAATCTGGTTACTTTTCCTCAATTTTCTGATAGAAACAATATCAGACAAAAGGAATATTATTTTCATTT
TAATCAGATAACCACTCTTCCGGAGAGTTTTTCACAATTAGATTCAAGTTACAGGATTAATATTTCAGGG
AATCCATTGTCGACTCGCGTTCTGCAATCCCTGCAAAGATTAACCTCTTCGCCGGACTACCACGGCCCAC
AGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGC
ATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGAAGAGCATGCC
AACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTG
AACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGC
TGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTG
GTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGT
TCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGA
AGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCTACTGCCGTGAAGGAAATGCGT
TTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAG
AGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGA
CCGCTGGGCGCAGGCAGAAGAGCAGAAGTATGAGATGCTGGAGAATGAGTACTCTCAGAGGGTGGCTGAC
CGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTG
AGACTGAACAGCAGATTTACCGTCAGTTGACTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTC
ACGACTGCACCATTCATA
Protein Sequence 
>gi|31983582|ref|NP_858211.1| invasion plasmid antigen [Shigella flexneri 2a str. 301] MFSVNNTHSSVSCSPSINSNSTSNEHYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH7.8 mutants had a lower rate of exit from the endocytic vacuoles into the cytoplasm in mouse macrophages than the wild-type strain (Fernandez-Prada et al., 2000).
COG COG4886S, under S: Function unknown
References
Fernandez-Prada et al., 2000: Fernandez-Prada CM, Hoover DL, Tall BD, Hartman AB, Kopelowitz J, Venkatesan MM. Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infection and immunity. 2000; 68(6); 3608-3619. [PubMed: 10816519].