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ipaH9.8 from Shigella flexneri 2a str. 301

Victor ID 914
Gene Name ipaH9.8 from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238048
NCBI Protein GI 56404031
Locus Tag CP0226
Protein Accession NP_858359.2
Other Database IDs UniProtKB-ID: IPA9_SHIFL
UniRef100: UniRef100_Q8VSC3
UniRef90: UniRef90_B2TT54
UniRef50: UniRef50_Q31SH3
UniParc: UPI000049774F
EMBL: AF047365
EMBL: AL391753
EMBL: AF348706
EMBL: AY206445
EMBL: AY879342
EMBL: AF386526
EMBL-CDS: AAC23714.1
EMBL-CDS: CAC05853.1
EMBL-CDS: AAK18544.1
EMBL-CDS: AAP79029.1
EMBL-CDS: AAW64849.1
EMBL-CDS: AAL72345.2
RefSeq_NT: NC_004851.1
PDB: 3L3P
DIP: DIP-46341N
EnsemblGenome: EBESCG00000093063
EnsemblGenome_TRS: EBESCT00000094019
EnsemblGenome_PRO: EBESCP00000090226
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 181457
Gene Ending Position 183094
Gene Strand (Orientation) +
Protein Name invasion plasmid antigen, secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|31983523:181457-183094 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
CATGTTACCGATAAATAATAACTTTTCATTGCCCCAAAATTCTTTTTATAACACTATTTCCGGTACATAT
GCTGATTACTTTTCAGCATGGGATAAATGGGAAAAACAAGCGCTCCCCGGTGAAGAGCGTGATGAGGCTG
TCTCCCGACTTAAAGAATGTCTTATCAATAATTCCGATGAACTTCGACTGGACCGTTTAAATCTGTCCTC
GCTACCTGACAACTTACCAGCTCAGATAACGCTGCTCAATGTATCATATAATCAATTAACTAACCTACCT
GAACTGCCTGTTACGCTAAAAAAATTATATTCCGCCAGCAATAAATTATCAGAATTGCCCGTGCTACCTC
CTGCGCTGGAGTCACTTCAGGTACAACACAATGAGCTGGAAAACCTGCCAGCTTTACCCGATTCGTTATT
GACTATGAATATCAGCTATAACGAAATAGTCTCCTTACCATCGCTCCCACAGGCTCTTAAAAATCTCAGA
GCGACCCGTAATTTCCTCACTGAGCTACCAGCATTTTCTGAGGGAAATAATCCCGTTGTCAGAGAGTATT
TTTTTGATAGAAATCAGATAAGTCATATCCCGGAAAGCATTCTTAATCTGAGGAATGAATGTTCAATACA
TATTAGTGATAACCCATTATCATCCCATGCTCTGCCAGCCCTGCAAAGATTAACCTCTTCGCCGGACTAC
CACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATG
CCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGA
AGAGCATGCCAACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCC
GGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTT
TCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAA
AACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGC
AGGGAAATGTTCCGCCTCGAAATTCTGGAGGATATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGG
ATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAA
GGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGA
AGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTA
CGGAAGCTGACCGCTGGGCGCAGGCAGAAGAGCAGAAATATGAGATGCTGGAGAATGAGTACCCTCAGAG
GGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAG
GTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGCCTG
AAAACGGCTCACAACTGCACCATTCATA
Protein Sequence 
>gi|56404031|ref|NP_858359.2| invasion plasmid antigen, secreted by the Mxi-Spa secretion machinery [Shigella flexneri 2a str. 301] MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALPALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH9.8 deletion mutant caused more severe inflammatory responses with increased pro-inflammatory cytokine production levels than did wild-type Shigella, which resulted in a 30-fold decrease in bacterial colonization in murine lungs (Okuda et al., 2005).
COG COG4886S, under S: Function unknown
References
Okuda et al., 2005: Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and biophysical research communications. 2005; 333(2); 531-539. [PubMed: 15950937].