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ipgB1 from Shigella flexneri 2a str. 301

Victor ID 912
Gene Name ipgB1 from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238045
NCBI Protein GI 31983578
Locus Tag CP0130
Protein Accession NP_858263.1
Other Database IDs UniProtKB-ID: IPGB_SHIFL
UniRef100: UniRef100_P33548
UniRef90: UniRef90_P33548
UniRef50: UniRef50_P33548
UniParc: UPI000012D7DE
EMBL: M86530
EMBL: AL391753
EMBL: AF348706
EMBL: X15319
EMBL: AF386526
EMBL: M34849
EMBL-CDS: AAD15223.1
EMBL-CDS: CAC05805.1
EMBL-CDS: AAK18448.1
EMBL-CDS: CAA33379.1
EMBL-CDS: AAL72342.1
EMBL-CDS: AAA98422.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093003
EnsemblGenome_TRS: EBESCT00000093959
EnsemblGenome_PRO: EBESCP00000090166
GenomeRev
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 113519
Gene Ending Position 114145
Gene Strand (Orientation) -
Protein Name IpgB1, secreted by the Mxi-Spa machinery, function unknown
DNA Sequence 
>gi|31983523:113519-114145 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TTTAATTTGTATTGCTTTGACGGTATACAGCCTTTAGAACCTCTGCGCTTATTTCTATTTGTAAAACTTT
TGTTGATTCATTAAATATTTTATCGTAGACGGAACTGGATACTAGATTTGTAAGATCCTTCATTTGTGTG
TTAAACAAATCCATGTCACTGCTATAGCGTTTTAAAATCTTTGCTCTGAGGCCAGATGAGGCAATCTCGT
TTAGTGCTGTATGACTGATAGATGTTTGTGCTGATTTTTCATCAAGTTTTATATCCGGGAATTTTTTTTC
AATAGCTGCAAATATGTTTCTTTTGTTATCTGAGGTCAAAACAACTCCATTGTGTATGGCCATCTCATCT
ATACTTCTGTTTATCATTGAAGAGACATAAGTGGTTCGCTCTTGGCTCATCCAACAAAATAGTTGATTCC
CCGAATTACTATCTTTTATTTTGTCTATGACGCTGTCCCTGATTTTATTTATATTCACCGGGCATCCAAA
ATTCTTCTGAGGAAAGCGTTGTTTTAAGTTAAAAACAGATAATATTTTCTTTACAAGCTTATTGCGACTT
AACGAATCAAATGATGGGCGAGGAATCGCGAATTCAACCTGTGGAAGTATTTTGTTTAGAATTTGCA
Protein Sequence 
>gi|31983578|ref|NP_858263.1| protein IpgB1 [Shigella flexneri 2a str. 301] MQILNKILPQVEFAIPRPSFDSLSRNKLVKKILSVFNLKQRFPQKNFGCPVNINKIRDSVIDKIKDSNSGNQLFCWMSQERTTYVSSMINRSIDEMAIHNGVVLTSDNKRNIFAAIEKKFPDIKLDEKSAQTSISHTALNEIASSGLRAKILKRYSSDMDLFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEVLKAVYRQSNTN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The invasiveness of the ipgB1 mutant was decreased to less than 50% of the wild-type level (100%) in a gentamicin protection or plaque forming assay (Ohya et al., 2005).
References
Ohya et al., 2005: Ohya K, Handa Y, Ogawa M, Suzuki M, Sasakawa C. IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells. Its activity to promote membrane ruffling via Rac1 and Cdc42 activation. The Journal of biological chemistry. 2005; 280(25); 24022-24034. [PubMed: 15849186].