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ipgD from Shigella flexneri 2a str. 301

Victor ID 909
Gene Name ipgD from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238042
NCBI Protein GI 31983575
Locus Tag CP0133
Protein Accession NP_858266.1
Other Database IDs UniProtKB-ID: IPGD_SHIFL
UniRef100: UniRef100_Q07566
UniRef90: UniRef90_Q07566
UniRef50: UniRef50_Q07566
UniParc: UPI000012D7DF
EMBL: L04309
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL: AY206439
EMBL-CDS: AAA26517.1
EMBL-CDS: CAC05808.1
EMBL-CDS: AAK18452.1
EMBL-CDS: AAL72339.1
EMBL-CDS: AAP78996.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093123
EnsemblGenome_TRS: EBESCT00000094079
EnsemblGenome_PRO: EBESCP00000090286
GenomeReviews: AF386526_GR
KEGG: sfl:CP01
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 116361
Gene Ending Position 117977
Gene Strand (Orientation) +
Protein Name IpgD, secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|31983523:116361-117977 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
AATGCACATAACTAATTTGGGATTGCATCAGGTTTCATTTCAAAGCGGAGATTCCTATAAAGGCGCAGAA
GAAACCGGAAAGCACAAAGGTGTAAGCGTGATTTCATATCAAAGAGTTAAAAATGGAGAAAGAAATAAGG
GGATCGAAGCGCTTAATCGATTATATTTACAGAACCAAACAAGCTTAACAGGAAAAAGCCTTTTGTTTGC
GCGTGACAGAGCTGAAGTTTTTTGCGAGGCAATAAAGTTGGCAGGTGGTGATACGTCAAAAATTAAAGCC
ATGATGGAACGATTAGATACCTATAAACTTGGTGAAGTTAATAAAAGACATATTAATGAGCTTAATAAAG
TAATAAGTGAAGAGATAAGAGCACAGCTAGGCATTAAAAATAAAAAGGAATTGCAAACGAAAATAAAACA
AATATTTACTGATTATTTAAATAATAAGAATTGGGGACCGGTCGACAAGAATATTAGTCATCATGGGAAA
AATTATGGTTTTCAATTAACTCCTGCCTCTCATATGAAGATAGGGAATAAAAATATATTTGTCAAAGAGT
ATAATGGAAAAGGAATTTGTTGTGCTTCTACGAGAGAGAGTGATCATATCGCGAATATGTGGCTTTCAAA
AGTGGTGGATGATGAGGGGAAGGAAATTTTTTCGGGTATCAGACATGGAGTTATATCAGCCTATGGATTG
AAAAAAAACTCATCTGAAAGAGCTGTTGCTGCTCGTAATAAAGCTGAGGAGTTAGTAAGCGCAGCATTAT
ATAGCAGACCAGAGTTATTATCACAGGCTTTGTCTGGTAAAACAGTAGATTTAAAGATTGTTTCGACTTC
TCTTCTGACGCCGACCAGTTTAACCGGGGGAGAGGAGAGTATGTTAAAAGATCAGGTGAACGCATTAAAA
GGGTTAAACTCTAAAAGGGGGGAGCCAACGAAATTATTAATTCGGAATAGTGATGGTCTTCTGAAAGAAG
TAAGCGTTAATCTAAAAGTGGTGACATTTAACTTTGGTGTAAATGAATTAGCGCTAAAAATGGGCTTAGG
CTGGAGGAATGTTGACAAGCTTAATGATGAATCAATATGTTCTTTGTTGGGGGATAATTTCCTCAAAAAT
GGTGTGATTGGAGGTTGGGCTGCAGAAGCAATAGAAAAAAATCCACCATGTAAGAATGATGTGATATATC
TGGCTAACCAGATAAAAGAGATTGTAACCAAAAAGTTACAAAAAAATGATAATGGAGAGCCGTATAAATT
GTCACAAAGAATGACTCTATTGGCTTATACTATAGGTGCTGTGCCTTGCTGGAATTGTAAGAGTGGGAAG
GACAGAACAGGTATGCAGGATGCTGAAATTAAAAGAGAAATAATAAGAAAACATGAAACAGGTCAGTTTT
CTCAATTAAATAGTAAATTATCCTCAGAAGAGAAAAGATTATTTTCTACTATTCTAATGAATAGTGGTAA
TATGGAAATCCAAGAGATGAATACTGGTGTGCCCGGAAATAAAGTCATGAAAAAATTGCCGCTATCTTCG
TTAGAGCTATCTTATTCTGAAAGAATAGGGGACCCAAAAATATGGAATATGGTGAAAGGGTATTCGTCAT
TTGTATA
Protein Sequence 
>gi|31983575|ref|NP_858266.1| hypothetical protein CP0133 [Shigella flexneri 2a str. 301] MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDRAEVFCEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVDKNISHHGKNYGFQLTPASHMKIGNKNIFVKEYNGKGICCASTRESDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVNALKGLNSKRGEPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIVTKKLQKNDNGEPYKLSQRMTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDPKIWNMVKGYSSFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipgD mutant is unable to dephosphorylate phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and induces shorter filapodia in host cells (Niebuhr et al., 2002).
References
Niebuhr et al., 2002: Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. The EMBO journal. 2002; 21(19); 5069-5078. [PubMed: 12356723].