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mxiA from Shigella flexneri 2a str. 301

Victor ID 908
Gene Name mxiA from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238036
NCBI Protein GI 31983569
Locus Tag CP0147
Protein Accession NP_858280.1
Other Database IDs UniProtKB-ID: MXIA_SHIFL
UniRef100: UniRef100_P0A1I5
UniRef90: UniRef90_P0A1I5
UniRef50: UniRef50_P0A1I5
UniParc: UPI000012FAAA
EMBL: M91664
EMBL: D10999
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL: M81458
EMBL-CDS: AAA26529.1
EMBL-CDS: BAA01771.1
EMBL-CDS: CAC05822.1
EMBL-CDS: AAK18466.1
EMBL-CDS: AAL72333.1
EMBL-CDS: -
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093209
EnsemblGenome_TRS: EBESCT00000094165
EnsemblGenome_PRO: EBESCP00000090372
GenomeReviews: AF3
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 126748
Gene Ending Position 128808
Gene Strand (Orientation) +
Protein Name MxiA, innermembrane protein, component of the Mxi-Spa secretion machinery
DNA Sequence 
>gi|31983523:126748-128808 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
AGTGATCCAGTCTTTTCTTAAGCAAGTAAGTACTAAGCCTGAATTAATTATATTAGTGCTTATGGTTATG
ATCATTGCTATGTTGATCATACCATTACCTACATACCTTGTTGATTTTTTAATAGGGCTTAATATTGTAC
TTGCTATTCTCGTTTTTATGGGATCATTTTATATTGAAAGAATATTGAGTTTTTCTACATTCCCTTCGGT
TTTGTTGATAACGACATTATTTCGTCTCGCTTTATCAATAAGTACTAGTCGACTAATTTTAGTTGATGCG
GATGCGGGTAAAATTATTACTACATTTGGCCAGTTTGTCATTGGTGATAGTCTGGCTGTAGGTTTTGTTA
TTTTTTCAATAGTAACTGTTGTGCAGTTCATTGTTATAACAAAAGGATCTGAAAGGGTTGCGGAGGTAGC
TGCTCGCTTTTCTCTTGACGGTATGCCGGGGAAACAAATGAGCATTGATGCGGATTTAAAGGCTGGAATT
ATTGATGCCGCAGGAGCTAAAGAAAGACGCAGTATTCTGGAACGTGAGAGTCAATTGTATGGTTCATTTG
ATGGAGCAATGAAGTTCATTAAAGGTGATGCAATTGCTGGCATCATTATTATTTTTGTCAATTTAATAGG
AGGTATTTCTGTTGGTATGAGTCAACATGGAATGTCCCTATCTGGTGCATTATCTACTTATACCATACTA
ACTATTGGTGACGGATTGGTCTCTCAGATTCCTGCTCTGTTAATTTCTATAAGTGCAGGATTTATCGTTA
CAAGAGTTAATGGTGATAGCGATAATATGGGACGTAACATAATGTCCCAGATATTTGGGAATCCTTTTGT
TCTCATTGTTACATCAGCTCTTGCCTTGGCGATAGGGATGTTGCCAGGTTTTCCGTTTTTTGTTTTTTTC
CTGATAGCAGTTACTTTGACGGCTTTATTCTATTATAAAAAGGTCGTAGAAAAAGAAAAAAGTCTGTCTG
AGTCTGATTCTAGTGGCTATACTGGTACATTTGATATTGATAATAGCCATGACTCATCTTTGGCAATGAT
AGAAAATCTGGATGCTATTAGTTCAGAAACCGTTCCTTTAATTTTATTATTTGCCGAAAATAAGATAAAT
GCAAATGATATGGAAGGTCTTATTGAAAGGATAAGAAGTCAGTTCTTTATTGATTATGGTGTCAGGCTTC
CAACTATTTTATATAGAACAAGCAATGAGCTTAAGGTCGATGATATTGTTTTGTTAATAAATGAGGTGCG
TGCCGATAGTTTTAATATATACTTTGACAAAGTGTGTATTACAGATGAAAATGGAGATATAGATGCTCTA
GGTATTCCTGTTGTTTCAACTTCATATAATGAACGTGTTATTTCTTGGGTAGACGTTTCATATACAGAAA
ATCTAACTAATATTGATGCTAAAATTAAAAGTGCTCAAGATGAATTTTATCACCAGTTGTCACAAGCTTT
ATTAAACAACATAAATGAGATTTTTGGTATACAAGAAACAAAAAATATGTTAGATCAGTTTGAAAATCGG
TATCCTGATCTATTAAAGGAAGTCTTCCGACATGTGACTATACAGAGAATTTCTGAGGTATTACAAAGAT
TGCTTGGAGAAAATATTTCTGTTCGCAATTTAAAACTTATTATGGAGTCTTTGGCGCTTTGGGCTCCCAG
AGAAAAAGATGTCATAACATTAGTTGAACATGTCCGTGCATCACTTTCTAGGTATATTTGTAGTAAAATA
GCTGTTTCTGGTGAGATTAAAGTTGTGATGCTTTCCGGATATATTGAGGATGCAATAAGAAAAGGGATAA
GGCAAACCTCTGGTGGCTCTTTCTTGAATATGGATATAGAGGTTTCGGATGAGGTAATGGAAACTTTAGC
ACATGCTTTGAGAGAATTGAGAAATGCAAAAAAAAATTTCGTTCTTTTGGTATCAGTAGATATACGTAGG
TTTGTTAAAAGACTTATAGATAACAGATTTAAGAGTATACTCGTTATATCGTATGCTGAGATTGATGAAG
CATATACCATTAATGTATTAAAGACTATTTA
Protein Sequence 
>gi|31983569|ref|NP_858280.1| Mxi-Spa secretion machinery protein MxiA [Shigella flexneri 2a str. 301] MIQSFLKQVSTKPELIILVLMVMIIAMLIIPLPTYLVDFLIGLNIVLAILVFMGSFYIERILSFSTFPSVLLITTLFRLALSISTSRLILVDADAGKIITTFGQFVIGDSLAVGFVIFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDAAGAKERRSILERESQLYGSFDGAMKFIKGDAIAGIIIIFVNLIGGISVGMSQHGMSLSGALSTYTILTIGDGLVSQIPALLISISAGFIVTRVNGDSDNMGRNIMSQIFGNPFVLIVTSALALAIGMLPGFPFFVFFLIAVTLTALFYYKKVVEKEKSLSESDSSGYTGTFDIDNSHDSSLAMIENLDAISSETVPLILLFAENKINANDMEGLIERIRSQFFIDYGVRLPTILYRTSNELKVDDIVLLINEVRADSFNIYFDKVCITDENGDIDALGIPVVSTSYNERVISWVDVSYTENLTNIDAKIKSAQDEFYHQLSQALLNNINEIFGIQETKNMLDQFENRYPDLLKEVFRHVTIQRISEVLQRLLGENISVRNLKLIMESLALWAPREKDVITLVEHVRASLSRYICSKIAVSGEIKVVMLSGYIEDAIRKGIRQTSGGSFLNMDIEVSDEVMETLAHALRELRNAKKNFVLLVSVDIRRFVKRLIDNRFKSILVISYAEIDEAYTINVLKTI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiA mutants were attenuated in invasion of HeLa cells (Andrews et al., 1991).
COG COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Andrews et al., 1991: Andrews GP, Hromockyj AE, Coker C, Maurelli AT. Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens. Infection and immunity. 1991; 59(6); 1997-2005. [PubMed: 2037361].