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mxiC from Shigella flexneri 2a str. 301

Victor ID 907
Gene Name mxiC from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238035
NCBI Protein GI 31983568
Locus Tag CP0146
Protein Accession NP_858279.1
Other Database IDs UniProtKB-ID: MXIC_SHIFL
UniRef100: UniRef100_Q04640
UniRef90: UniRef90_Q04640
UniRef50: UniRef50_Q04640
UniParc: UPI000012FAAB
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL: X67206
EMBL: M91664
EMBL-CDS: CAC05821.1
EMBL-CDS: AAK18465.1
EMBL-CDS: AAL72332.1
EMBL-CDS: CAA47645.1
EMBL-CDS: -
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 2VIX
PDB: 2VJ4
PDB: 2VJ5
EnsemblGenome: EBESCG00000093114
EnsemblGenome_TRS: EBESCT00000094070
EnsemblGenome_PRO: EBESCP00000090277
GenomeReviews: AF38652
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 125668
Gene Ending Position 126735
Gene Strand (Orientation) +
Protein Name MxiC, secreted by and putative component of the Mxi-Spa secretion machinery, similarities to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica)
DNA Sequence 
>gi|31983523:125668-126735 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TATGCTTGATGTTAAAAATACAGGAGTTTTTAGCTCTGCATTCATTGATAAGTTGAATGCAATGACAAAT
TCAGATGATGGAGATGAGACTGCTGATGCAGAGCTTGATTCTGGCTTGGCTAATAGCAAGTATATTGACT
CATCTGATGAGATGGCTTCCGCTCTTTCGTCATTTATAAACAGAAGAGACCTTGAGAAACTGAAAGGAAC
AAATAGTGATAGTCAGGAACGTATTTTAGATGGGGAAGAAGATGAAATTAATCACAAGATTTTTGATTTA
AAGAGAACGTTAAAAGATAACCTTCCTCTAGATCGGGATTTTATAGACAGACTAAAGAGATATTTTAAAG
ATCCAAGTGATCAAGTCTTAGCATTAAGGGAACTTTTGAATGAAAAAGATCTTACTGCTGAACAAGTCGA
ATTATTAACTAAAATTATTAATGAGATAATATCAGGTAGTGAAAAAAGTGTTAATGCTGGAATAAATTCA
GCTATACAGGCTAAATTATTTGGCAACAAAATGAAACTTGAACCACAGCTTTTGCGTGCATGTTATCGTG
GTTTTATCATGGGGAACATATCAACAACAGATCAGTATATAGAATGGCTTGGTAATTTTGGTTTTAATCA
CAGACATACAATTGTGAATTTTGTAGAGCAGTCACTGATTGTAGACATGGATTCTGAGAAACCGAGCTGT
AATGCTTATGAGTTTGGTTTTGTGTTATCTAAATTAATTGCAATTAAGATGATTAGAACTTCAGACGTAA
TTTTTATGAAGAAACTGGAATCCTCAAGCTTGCTAAAAGATGGCAGTTTAAGTGCAGAGCAGCTATTGCT
AACTTTATTATATATTTTTCAATATCCAAGTGAAAGTGAGCAAATTCTTACTTCTGTTATAGAAGTATCA
CGAGCCAGTCATGAGGATTCTGTAGTGTATCAAACATATCTATCTTCTGTTAATGAAAGTCCTCATGATA
TATTTAAAAGTGAAAGTGAAAGAGAAATTGCGATCAATATTCTACGAGAGCTTGTCACAAGTGCATACAA
GAAAGAGCTTTCTAGATA
Protein Sequence 
>gi|31983568|ref|NP_858279.1| Mxi-Spa secretion machinery protein [Shigella flexneri 2a str. 301] MLDVKNTGVFSSAFIDKLNAMTNSDDGDETADAELDSGLANSKYIDSSDEMASALSSFINRRDLEKLKGTNSDSQERILDGEEDEINHKIFDLKRTLKDNLPLDRDFIDRLKRYFKDPSDQVLALRELLNEKDLTAEQVELLTKIINEIISGSEKSVNAGINSAIQAKLFGNKMKLEPQLLRACYRGFIMGNISTTDQYIEWLGNFGFNHRHTIVNFVEQSLIVDMDSEKPSCNAYEFGFVLSKLIAIKMIRTSDVIFMKKLESSSLLKDGSLSAEQLLLTLLYIFQYPSESEQILTSVIEVSRASHEDSVVYQTYLSSVNESPHDIFKSESEREIAINILRELVTSAYKKELSR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiC mutant has a 10-fold decrease in efficiency in invading epithelial cells (Botteaux et al., 2009).
References
Botteaux et al., 2009: Botteaux A, Sory MP, Biskri L, Parsot C, Allaoui A. MxiC is secreted by and controls the substrate specificity of the Shigella flexneri type III secretion apparatus. Molecular microbiology. 2009; 71(2); 449-460. [PubMed: 19017268].