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ospB from Shigella flexneri 2a str. 301

Victor ID 899
Gene Name ospB from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238026
NCBI Protein GI 31983559
Locus Tag CP0003
Protein Accession NP_858136.1
Other Database IDs UniProtKB-ID: Q99Q23_SHIFL
UniRef100: UniRef100_Q7AY55
UniRef90: UniRef90_Q7AY55
UniRef50: UniRef50_Q7AY55
UniParc: UPI00000BEF8E
EMBL: AF386526
EMBL: AL391753
EMBL-CDS: AAL72323.1
EMBL-CDS: CAC05770.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093053.
EnsemblGenome_TRS: EBESCT00000094009
EnsemblGenome_PRO: EBESCP00000090216
GenomeReviews: AF386526_GR
KEGG: sfl:CP0003
HOGENOM: HBG210283
OMA: SITATEM
ProtClustDB: CLSK504960
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 1175
Gene Ending Position 2041
Gene Strand (Orientation) +
Protein Name OspB, protein secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|31983523:1175-2041 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TATGAATTTAGATGGTGTTAGACCATACTGTAGAATAGTCAATAAAAAGAATGAAAGCATATCAGATATT
GCATTTGCACATATAATAAAAAGGGTAAAAAATTCATCATGTACTCACCCAAAAGCAGCATTGGTTTTTT
TAGGAGAGAAAGGTTTTTGTGATAGCAATGATGTTCTATCTATTATGGGACAACAAATACCAAGAGTATT
TAAGAACAAGATGTTATATGATTATGTTTTTAAAAATGAAAAAAGTAAAAATGATTTTCTAAAAATGGCT
GAATCATGGCTACCACAGAGTGAACCAATAGTAATAAATAATGATGATGACGCATTGAATGCTGCTGCTT
ATTTTTCTGTAAAAAAAGCGAAAATAAAAACAGTAAACGATACTGATTTTAAAGAGTATAATAAGGTTTA
TATTCTTGGGCACGGTAGTCCTGGTTCTCATCAATTAGGCCTTGGTTCGGAACTTATTGATGTACAAACA
ATCATTTCAAGAATGAAAGACTGTGGTATTCTAAATGTGAAAGATATCCGTTTTACTTCATGCGGCTCCG
CTGATAAAGTGGCTCCTAAAAATTTTAACAATGCCCCTGCTGAAAGTCTTTCTTGTATCCTTAACTCTCT
GCCTTTTTTTAAGGAAAAAGAATCTTTGCTAGAGCAGATAAAAAAACACCTTGAAAACGATGAGTCATTG
AGTGATGGTCTAAAAATATCCGGCTATCATGGATATGGAGTTCACTATGGTCAAGAGCTTTTTCCCTACT
CACATTATCGTTCAACTTCAATTCCTGCTGATCCGGAGCATACAGTAAAAAGAAGCTCTCAGAAAAAGAC
TTTTATTATTAATAAAGAACTGGATTA
Protein Sequence 
>gi|31983559|ref|NP_858136.1| OspB protein [Shigella flexneri 2a str. 301] MNLDGVRPYCRIVNKKNESISDIAFAHIIKRVKNSSCTHPKAALVFLGEKGFCDSNDVLSIMGQQIPRVFKNKMLYDYVFKNEKSKNDFLKMAESWLPQSEPIVINNDDDALNAAAYFSVKKAKIKTVNDTDFKEYNKVYILGHGSPGSHQLGLGSELIDVQTIISRMKDCGILNVKDIRFTSCGSADKVAPKNFNNAPAESLSCILNSLPFFKEKESLLEQIKKHLENDESLSDGLKISGYHGYGVHYGQELFPYSHYRSTSIPADPEHTVKRSSQKKTFIINKELD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospB mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2009).
References
Zurawski et al., 2009: Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Molecular microbiology. 2009; 71(2); 350-368. [PubMed: 19017275].