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ospC1 from Shigella flexneri 2a str. 301

Victor ID 898
Gene Name ospC1 from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238025
NCBI Protein GI 31983558
Locus Tag CP0094
Protein Accession NP_858227.1
Other Database IDs UniProtKB-ID: Q8VSJ7_SHIFL
UniRef100: UniRef100_D2AJE9
UniRef90: UniRef90_B2TST5
UniRef50: UniRef50_Q3YTS0
UniParc: UPI00000BD2B7
EMBL: AF386526
EMBL-CDS: AAL72322.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093229.
EnsemblGenome_TRS: EBESCT00000094185
EnsemblGenome_PRO: EBESCP00000090392
GenomeReviews: AF386526_GR
KEGG: sfl:CP0094
HOGENOM: HBG683600
OMA: SIANQKE
ProtClustDB: CLSK504963
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 79938
Gene Ending Position 81350
Gene Strand (Orientation) -
Protein Name OspC1, secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|31983523:79938-81350 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
ATTAAATATATTTATTGTCAGATGTTGCACCATATTTCAATAATAGTTTTATCATTTCTGCATTCTCATA
TTTTATTGCGTTATCCAACATACAATCCCCACTATTAGTTTTTTTGAACTTTGTGTTTACATCAACCAAT
CCCTTATTGATAAAATACTCAAGTACTTTACAGCTTGAATTATGAGCGCTAAGTAGATACTCAATATCAT
ACAACTCATGCTTTATGGAAATAACATCTTGTCTAGTTATCTCAAAATTAGATAATATATATAAGGCGAC
ATCCTCTTTTTGATTAGTAATCGAAAGAAAAAGAGCCTGGAGAGCAATTTTTTTGTTAGTGACCTGCTTG
TTAATTTCTTCGTAATTAGATGCTGTAACAGCCTCCTCTAAGGATATTTCTCTAATCTTAACTTTTTTGA
AGTTTTCTGTACTTACCATCCTAGGTATATGGTACTCTGGCTGAAAAACAAAGTTTATGATTCTATCCAG
ATCCACAGGGGCAAGATTTTTTCCATAGCAAAACTCCTTGAAGCTTTGGTCTTCACTTTTTCTAATAAAG
TCAATCAGGTATAATCCGAGCCCTAACTTCATATCTTTAGTATTGAATATTGGTACATCTATAATTCCTT
TACTTCCATGTACGTATCGACTAACTTCTTTATTAACCTCTGAAAATTTATCTAAAAATGATTGGTGCTC
ATGGTAAAAAACAGGTGGAATAGCATTATCAAAGTGATCGGTTAATGTCATATATCCATATGGAGAGTCA
TGATCAATGATATACGCATTTGCACCAAAATCAACAGTGTGATGTTTTGTATTCAGGGGGTGTTTTTTCT
GATGGTTAGAGATTTCAACGCCAAAAAACACAAAGTCATGATTAGCTATTTTTTTTATATCATCAGCGTA
TGTGTTTCGTTTTGTGCATATTCCTTCAGACTGAATTTTATTGAATGACTTAATGTTTAAAATTTTATCA
GACAAATCAGAATTACTTTGATGTCTGAAGATTAAATCAGAATTAATAATTAGCGAAAGCAAATTGAGTT
CCTCTGCAGAAAGAGGATGAAGTTTTTCCCTTATTTCAGATATATAATGCTTCGATAATCTGTCAAGGTG
CTCAATAGCCTTAAATGAGGCTTTAGCGTCTGATGGTGCATCAATTGCTATATTTAAAGATTTAAAGTTA
GAGCCTTGAGAGAACATTCTACTATAACTCTGTGCTGCTATAGTTTTCCTAAAGAAACTTTTAATAATAT
TTGCACTATCTTTTAAATTTTTTTCATCTGGCATAGTTTGTTGTGCAGCGTTTCGCACTGATGTCACTTT
TGGAAACAATGTATGTAATCTGTTATCCATAGAATCTATATTGCATTGGGTATTTGCTGAGTTCAGTGTT
TCTGATATATTCA
Protein Sequence 
>gi|31983558|ref|NP_858227.1| protein OspC1 [Shigella flexneri 2a str. 301] MNISETLNSANTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKNLKDSANIIKSFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIREKLHPLSAEELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTKRNTYADDIKKIANHDFVFFGVEISNHQKKHPLNTKHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFLDKFSEVNKEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYGKNLAPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFLSITNQKEDVALYILSNFEITRQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospC1 mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2006).
References
Zurawski et al., 2006: Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infection and immunity. 2006; 74(10); 5964-5976. [PubMed: 16988276].