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virK from Shigella flexneri 2a str. 301

Victor ID 896
Gene Name virK from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238020
NCBI Protein GI 31983528
Locus Tag CP0237
Protein Accession NP_858370.1
Other Database IDs UniProtKB-ID: Q8VSB6_SHIFL
UniRef100: UniRef100_Q8VSB6
UniRef90: UniRef90_Q08JR6
UniRef50: UniRef50_Q9X694
UniParc: UPI00000B609D
EMBL: AF386526
EMBL-CDS: AAL72292.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093018.
EnsemblGenome_TRS: EBESCT00000093974
EnsemblGenome_PRO: EBESCP00000090181
GenomeReviews: AF386526_GR
KEGG: sfl:CP0237
HOGENOM: HBG468105
OMA: FHASYDE
ProtClustDB: CLSK862866
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 193646
Gene Ending Position 194596
Gene Strand (Orientation) +
Protein Name VirK, required for proper localization of IcsA (VirG) at the surface of bacteria
DNA Sequence 
>gi|31983523:193646-194596 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TATGTTTTCTGTAAGTAACTTATCATTTATCGGTTTCCTTAAAAGGATTGTTTTTTCCTCAGATTCACTC
CCGGGGAAGTGGGAACACAGAAAATTCCGGTTCATGTACATTTTGCGATGTGCTATAAATCCGGTTGCCA
GTATTCGATATTATTACGAACTGCGTTCCTTGCAGTGCATTGAGGATATTCTGGCAATACAACCCACGTT
GCCAGCAAGAATTCATCGACCTTATTTGCATAAAGGGGGGCGAGCCTGGTCCCGGGGGCAATATATTCTT
GAGCATTATCGCTTTGTGCAAAATTTGCCAGAAAAATATTCTGAATTTTTGTTTCCACAAAAATCGGTAT
CATTAGTCCAATTCATCGGGAAAGATGGAGAGGATTTTGATATCCAGTGTTCTCCCAGTGGTTTTGACCG
GGAAGGAGAGTTGATGTTGTCATTGTTTTTCAATAAAATAGTGATTGCCCGGTTAACATTTTCAGTCATT
CTGACTCAAAATGGACACACCGCTTTTATTGGCGGATTACAGGGAGCCCCCAAAAATACCGGACCTGATA
TTATTCGGTGCGCAACCCGGGCCTGTTATGGGCTTTTCCCAAAACGGATTATTTTTGAAGCATTTTGTGC
GTTGATGAAAGCTTGTAATGTCTCTGAGTGTCTGGCAGTCAGTGAGCACAGTCATGTTTTCCGGCAATTG
AGATACTGGTATCAGAAACGCAAAACCTTTGTTGCTGTCTACAGTGATTTCTGGGAGTCTGTAGCAGGGA
AAACCTGTGGTGACTGGTACAAATTACCAACACAGGTGGTTCGAAAGCCGCTAAGCAATATAGCTAGTAA
AAAACGCTCTGAGTATCGAAAACGATACGCTTTGCTGGATTATATCCATGAAACTGCTATCCGCTCTTTG
GATGCATATCCTGTAAACTCAGAACATTATGACTTAAATTA
Protein Sequence 
>gi|31983528|ref|NP_858370.1| hypothetical protein CP0237 [Shigella flexneri 2a str. 301] MFSVSNLSFIGFLKRIVFSSDSLPGKWEHRKFRFMYILRCAINPVASIRYYYELRSLQCIEDILAIQPTLPARIHRPYLHKGGRAWSRGQYILEHYRFVQNLPEKYSEFLFPQKSVSLVQFIGKDGEDFDIQCSPSGFDREGELMLSLFFNKIVIARLTFSVILTQNGHTAFIGGLQGAPKNTGPDIIRCATRACYGLFPKRIIFEAFCALMKACNVSECLAVSEHSHVFRQLRYWYQKRKTFVAVYSDFWESVAGKTCGDWYKLPTQVVRKPLSNIASKKRSEYRKRYALLDYIHETAIRSLDAYPVNSEHYDLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virK mutants have attenuated ability for intracellular spreading in host cells (Wing et al., 2005).
COG COG2990S, under S: Function unknown
References
Wing et al., 2005: Wing HJ, Goldman SR, Ally S, Goldberg MB. Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus. Infection and immunity. 2005; 73(2); 1217-1220. [PubMed: 15664968].