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ospD3 from Shigella flexneri 2a str. 301

Victor ID 895
Gene Name ospD3 from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238012
NCBI Protein GI 31983552
Locus Tag CP0093
Protein Accession NP_858226.1
Other Database IDs UniProtKB-ID: Q99Q01_SHIFL
UniRef100: UniRef100_Q7BEN0
UniRef90: UniRef90_Q47634
UniRef50: UniRef50_Q47634
UniParc: UPI00000BEF65
EMBL: AF386526
EMBL: AL391753
EMBL-CDS: AAL72316.1
EMBL-CDS: CAC05789.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093020.
EnsemblGenome_TRS: EBESCT00000093976
EnsemblGenome_PRO: EBESCP00000090183
GenomeReviews: AF386526_GR
KEGG: sfl:CP0093
HOGENOM: HBG683620
OMA: CERNNAN
ProtClustDB: CLSK504968
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 77912
Gene Ending Position 79609
Gene Strand (Orientation) -
Protein Name OspD3 (SenA), probably secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|31983523:77912-79609 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
TTCAGCTTTTTATATTCTTCATAATTTCTAGAAAATCACTTCCATTTTTTTTGTCCAAGTGTTCTGCTAT
TTCTTCAGGTGTAATATTTTCATTTTTTATTATTCCCATATAAGTTTTTATTGCCTCAAAATTCCTATTT
TGAAAAGCTATAATTAATCCAGATACCCCATTTGGGCCTTCTGCTGCCAGTAATTTTGATGCCTGATGTG
GAGTAAGGTCTGCAGTGTGAAGTATTTTCCCATAAGCAATAATTGTTTCTACACATCCATTATGCAAGGC
TACAAACAATCCAGATAAACCATTAGAATCTTTCGCTTCTAACAGCTCTGCTTTTTTATCCAAGTTAAGT
TTTGCCTCATTCAAGATATCACCATAAGCTAAGATTGCATCAGCCTGTCCATTATTCAATGCTAACAGAA
GTCCGGGAACATTGTCATATCTCCTTGAGGCCAGCAAATTTACAATATCCTCTGAGTTGAGGAGAGGGGG
GCTAAGAATGAGCTCACCGTATGCGCGTATAGCATCTGCATGTCCATTTTGAAGAGCAAACATTAGTCCG
GGTATCTGTCTGTGTACTTCATCATAATAATAAGCGGTCAGCAAATTTTTCAGCTTATTGTATTCGATAT
TTATTGCTCTCTTCTTGAGAAGCCTTCCGTATGTTTTGATAGTTTCTGCATGCCCATTTTGAAGTGCTTG
GGATAAACCCGATATTCGTCCTCCCATTCCTTCCGCAGTTAGTAGTTCTACCGTTTTATCAAGGTTAAGT
CCAGAAGTTTCCAAGAGTTCTCCGTATGCTAAGATTGTATCTGAATGCCCATTTTGTAAAGCTAAAAGCA
ATCCTGACAAACCATCGTCATTTTTGGCTGCCAAAAGTAATTCTAACGTATTGTCTGAAAGGTCAGATAG
TTGTACGACTCTTGTTACTTTTTGGATTAGCTCAGTCAATCCCATACGCATCGCGTGATAAATAACTTTG
GGGTGAAGTAAATTATCAGGCCATCTGATTATGGAGGACATGCTTGTTGGAGTATGTCTGTCCACAAATA
TAGACATACCGTCGGATATAAGACCATAACATTTCTGATGTTTTTCATCAAGAAAATTATCTACAGTCAG
TTTTTTTATTTTAGCTAAGTTAAATTTGTTAAACTCTGCTCGTAAATGAGTTGCTGTATGGTTGGGATCA
TAAAGCTGAATGACAAAATCCCCCCCATTTTTAGTTTCTTTAATCTTCAAGCCTAATGCCATATTGTGAT
TTGATGTACTTATTTCTAGTGCTCTGCTTTTTTCGGAATGAAAAATCATTTCATTGAAAATATAAAAAAT
AATATCTCCCCATGAACCGTTTTCAACAAAATAAATAATAGCAGGCACATTAATAGCCTTTTCTTCTTCA
CTCACTGAAACATAATTTTTAATTTCATCCGGAAAAGCAAAGTGATGATAATCCACGTGACCACTACTTT
TGTTAAACTGTGCTATCCAGTAGGAAGCTAAATGTCGACAGACAATAAGTCTTCCAGAGTGATCGGTAAC
TTGGCAATTTAGATTTAATAAAAAACTCCTCTTGTCAGAAAAATATGGCAATTGTTTTGAGTGCAATAGA
GACTGGATTGTCTCAACAGAGACGTTGTCTTTATTTATCATATTTTGCAAACATATTTTCCTTGATGGGA
TTAAATTTACTGATGGCA
Protein Sequence 
>gi|31983552|ref|NP_858226.1| hypothetical protein CP0093 [Shigella flexneri 2a str. 301] MPSVNLIPSRKICLQNMINKDNVSVETIQSLLHSKQLPYFSDKRSFLLNLNCQVTDHSGRLIVCRHLASYWIAQFNKSSGHVDYHHFAFPDEIKNYVSVSEEEKAINVPAIIYFVENGSWGDIIFYIFNEMIFHSEKSRALEISTSNHNMALGLKIKETKNGGDFVIQLYDPNHTATHLRAEFNKFNLAKIKKLTVDNFLDEKHQKCYGLISDGMSIFVDRHTPTSMSSIIRWPDNLLHPKVIYHAMRMGLTELIQKVTRVVQLSDLSDNTLELLLAAKNDDGLSGLLLALQNGHSDTILAYGELLETSGLNLDKTVELLTAEGMGGRISGLSQALQNGHAETIKTYGRLLKKRAINIEYNKLKNLLTAYYYDEVHRQIPGLMFALQNGHADAIRAYGELILSPPLLNSEDIVNLLASRRYDNVPGLLLALNNGQADAILAYGDILNEAKLNLDKKAELLEAKDSNGLSGLFVALHNGCVETIIAYGKILHTADLTPHQASKLLAAEGPNGVSGLIIAFQNRNFEAIKTYMGIIKNENITPEEIAEHLDKKNGSDFLEIMKNIKS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sen deletion mutant elicited lower rises in mucosal short-circuit current than the wild type, suggesting that the senA/ospD3 gene encodes an enterotoxin of Shigella (Nataro et al., 1995).
References
Nataro et al., 1995: Nataro JP, Seriwatana J, Fasano A, Maneval DR, Guers LD, Noriega F, Dubovsky F, Levine MM, Morris JG Jr. Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infection and immunity. 1995; 63(12); 4721-4728. [PubMed: 7591128].