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ospG from Shigella flexneri 2a str. 301

Victor ID 893
Gene Name ospG from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1238010
NCBI Protein GI 31983550
Locus Tag CP0227
Protein Accession NP_858360.1
Other Database IDs UniProtKB-ID: OSPG_SHIFL
UniRef100: UniRef100_Q326Z4
UniRef90: UniRef90_Q326Z4
UniRef50: UniRef50_Q326Z4
UniParc: UPI00000BEF80
EMBL: AF386526
EMBL: AF348706
EMBL: AY879342
EMBL: AL391753
EMBL-CDS: AAL72314.1
EMBL-CDS: AAK18547.1
EMBL-CDS: AAW64846.1
EMBL-CDS: CAC05855.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093134
EnsemblGenome_TRS: EBESCT00000094090
EnsemblGenome_PRO: EBESCP00000090297
GenomeReviews: AF386526_GR
KEGG: sfl:CP0227
HOGENOM: HBG468694
OMA: YSATKND
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 183823
Gene Ending Position 184413
Gene Strand (Orientation) +
Protein Name OspG, secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|31983523:183823-184413 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
CATGAAAATAACATCTACCATTATTCAAACACCTTTTCCATTTGAGAATAATAATTCTCATGCTGGCATA
GTAACGGAGCCCATTCTCGGTAAGTTAATAGGTCAGGGGTCGACAGCAGAAATCTTTGAAGATGTGAATG
ATTCATCTGCTTTGTATAAAAAGTATGATCTTATTGGCAACCAGTACAATGAGATTCTGGAAATGGCTTG
GCAAGAATCTGAGCTTTTTAATGCTTTTTATGGCGATGAAGCATCCGTTGTTATACAGTATGGCGGAGAT
GTGTACCTCCGAATGCTGCGCGTGCCTGGGACTCCCCTTAGTGACATTGATACAGCTGATATCCCTGATA
ATATAGAGAGCCTTTATCTACAGTTGATATGTAAATTGAATGAGTTGAGTATAATCCATTACGATCTTAA
TACAGGTAATATGCTGTATGATAAAGAAAGTGAAAGTTTATTCCCAATAGATTTTCGCAATATTTATGCT
GAATATTACGCTGCAACCAAAAAAGATAAAGAGATTATCGACCGACGATTACAAATGCGTACAAATGATT
TTTATTCGTTATTAAACAGGAAATATTTATA
Protein Sequence 
>gi|31983550|ref|NP_858360.1| protein OspG [Shigella flexneri 2a str. 301] MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Upon infection of ileal loops in rabbits, the ospG mutant induced a stronger inflammatory response than the wild-type strain, indicating that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium (Kim et al., 2005).
COG COG0661R, under R: General function prediction only
References
Kim et al., 2005: Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(39); 14046-14051. [PubMed: 16162672].