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virA from Shigella flexneri 2a str. 301

Victor ID 887
Gene Name virA from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1237992
NCBI Protein GI 56404024
Locus Tag CP0181
Protein Accession NP_858314.2
Other Database IDs UniProtKB-ID: VIRA_SHIFL
UniRef100: UniRef100_Q7BU69
UniRef90: UniRef90_Q326N4
UniRef50: UniRef50_Q3YTK0
UniParc: UPI00000BB710
EMBL: D26468
EMBL: AF047364
EMBL: AL391753
EMBL: AF348706
EMBL: AY206441
EMBL: AF386526
EMBL-CDS: BAA05480.1
EMBL-CDS: AAC23713.1
EMBL-CDS: CAC05836.1
EMBL-CDS: AAK18501.1
EMBL-CDS: AAP79023.1
EMBL-CDS: AAL72296.2
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 3EB8
PDB: 3EE1
EnsemblGenome: EBESCG00000093130
EnsemblGenome_TRS: EBESCT00000094086
EnsemblGenome_PRO: EBE
Taxonomy ID 198214
Plasmid No pCP301
Gene Starting Position 147912
Gene Ending Position 149114
Gene Strand (Orientation) -
Protein Name VirA, secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|31983523:147912-149114 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence
CTTAAACATCAGGAGATATGATGGCAAATGATACTTGACGACTTTCTGGAGGGATAGCATTGCGAAGCCC
TTCACTGCTTGGAAGTGTTCCAGCATGAACGAGATAGCTTGTTTCTATTTTATTAATACCAACACCATTA
CATGTTATGTGCGATGGTAATATTGATGAGCTAACTTCGTAAGCCCTCCCCCCAGAGGCAGAGATTGCAG
TGTCGTTTTTAGGGACAACTGCGTTGATTTTTATAATATGTCCACAATTGTTAATAACTCGTTGTTCAGG
CATGAAATTAAGCCTGTTTTCTATGTTTTCGGACATAATTTGGGCATATATGTGTTCCACAGAGGAAGAC
GTGATGTGAAGAGATTGCCAGAATGCAGATGTTAGTGCAGATATAAATGCAGGGTCTTGAAAGAGTGAAG
TAAACAAAAGTTTTTCTGTTTGAAAACATAGGTCTTGTTGGGGGAAGTTTGAATTGATTATTTTATTTAC
TTGGTTGTAACTTAGCATTTGAAGCTCTTTTTTGCTATCAATGAATTCATTAATTCCTAACTCATTAATT
AGATCTGCAATTAATTTTAGTGGTATTTCAATATTGTTGAAATATATTTTTGTACTATTGCTGTCAGATG
CTCGAATATCTCTGTAAATATCATGCCAAACACTATTAAAATCAGTGTCTTTAACGTGGAAGTAATCATC
GTTTGGTATTATCGATGTACAGCAATTAATGGCTGTTTCAATAACTTCTGGTGCAGGCTTGTGAGTTTTA
AAATTCCCTGATACCGGAGCTGTAATAGTATGTACTTTTCCTAAGTTGAATTGTTTGGGGGGGAGTGAAC
TTAACAAGTTATTATATTCTTTTGATGAAAGTTGAGTGGATTGTATTTTATCTCCATCAAGATAAAAAAC
CGAACATATGCCTTTGTTAAGGCATAGCCGTATTGAAATGCCATCTATGTTTGCGTGGGCAAACTCTCCG
TCCATTTTATCTTGTGATAGTGATGGTGAGAAACTATCCATTAGTTTTTTTTCGCTATGTTTTTCGGCTA
GAGTTTCGTGTGGAGAATATATGCCGAAAGTTATTATTTTCAGTAAAATGTCACAAAAACTCAATTTATT
CCAACTTACTTCTGTAGTTGATTTGACAGTTGACATCCATGATGAGTCATTTCTTTCATGGTTAGTTATG
TTTGATGTCTGCA
Protein Sequence 
>gi|56404024|ref|NP_858314.2| VirA protein [Shigella flexneri 2a str. 301] MQTSNITNHERNDSSWMSTVKSTTEVSWNKLSFCDILLKIITFGIYSPHETLAEKHSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFHVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virA mutants did not move within the host cytoplasm and failed to move into adjacent cells (Yoshida et al., 2006).
References
Yoshida et al., 2006: Yoshida S, Handa Y, Suzuki T, Ogawa M, Suzuki M, Tamai A, Abe A, Katayama E, Sasakawa C. Microtubule-severing activity of Shigella is pivotal for intercellular spreading. Science (New York, N.Y.). 2006; 314(5801); 985-989. [PubMed: 17095701].