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envZ from Shigella flexneri 2a str. 301

Victor ID 881
Gene Name envZ from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1026481
NCBI Protein GI 24114667
Locus Tag SF3423
Protein Accession NP_709177.1
Other Database IDs UniProtKB-ID: ENVZ_SHIFL
UniRef100: UniRef100_P0AEJ4
UniRef90: UniRef90_P0AEJ4
UniRef50: UniRef50_P0AEJ4
UniParc: UPI0000000AFB
EMBL: AJ288905
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: CAC34269.1
EMBL-CDS: AAN44884.1
EMBL-CDS: AAP19295.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
EnsemblGenome: EBESCG00000086483
EnsemblGenome_TRS: EBESCT00000087438
EnsemblGenome_PRO: EBESCP00000084260
EnsemblGenome: EBESCG00000089055
EnsemblGenome_TRS: EBESCT00000090011
EnsemblGenome_PRO: EBESCP00000086647
Geno
Taxonomy ID 198214
Gene Starting Position 3503802
Gene Ending Position 3505154
Gene Strand (Orientation) -
Protein Name osmolarity sensor protein
DNA Sequence 
>gi|24111450:3503802-3505154 Shigella flexneri 2a str. 301, complete genome
TTTACCCTTCTTTTGTCGTGCCCTGCGCCCGCGTTACCGGCACTGGCAGCCAGGCGCGAATGGAAAGCCC
GCCCCGCTCGCTGGTGCCAAGCTCCAGCATCCCGTTATGGTTATCCACGATACGCTGCACAATTGCCAGC
CCTAATCCCGTGCCGCTAATGGTGCGCGCACTGTCGCCGCGGACAAACGGCTGGAACAGGTGCTTACGTT
GTTCCGGCGCAATTCCCGGACCGTCATCTTCCACCTGGAACCAGGCGCGATTCGGCTCCGTTCCGCTGCT
GACTTTGATCCAGCCATTGCCATAACGGGCGGCGTTGACCACCATATTCGCCACCGCGCGTTTGATCGAC
AGCGGGTGCATTTTCACTTCAATGCTGCCGGGGTAAAGCGCGGTTTCAATTTCCCGCTCATAGCCACTTT
CGGCAGCAATCACCTCACCGAGCACTGCATTAAGATCCGCCATTTCCATCGGCATCTCCTGCCCGGTGCG
CAGGTAGTCGATAAACTGCTCAATGATGGCGTTGCACTCTTCGATATCTTTATTGATCGATTCTGCCAGA
TAGCCATCCTGCTCGCTCATCATCTCAGTCGCCAGGCGAATACGCGTCAGCGGCGTGCGCAAGTCGTGAC
TTACCCCCGCCATCAGCAGCGTGCGGTCATCCGCCAGTTGCTTAACACCAGCCGCCATATGGTTAAAGGC
ACGGGTAACGGAACGCACCTCCGAAGCGCCATATTCACGCAGCGGCGGCGGAATAATCCCTTTACCAACC
TGCAAGGCTGCGTGTTCGAGATCGACCAACGGTCGGTTCTGGATACGAATAAACAGCCACGCCCCGCCTA
TCGCCAATAGCATAATCGCCAGCGTATAGCGGAACAGCGGAGAGAAATCGCCCTGATGAATTTCGGTCAG
CGGCACGCGTACCCAGATATTGGGCGACAGCCAGGTTTTCAGCCAGACGACAGGCGAACTTTTGTTGACC
TCAACGCGCACTTCCGTCGGGCCGCCCAGTTGCTGTGCCATCTGATGGCTTAAGAATTCATAGTGTTGCG
CCCAACGCAGACCTGCCTCTTCGGCAGCCTCGTTGGAGTAGAGAGAGATCCCCAGCTCACGGTAGATCTC
CCGACGGAAAGCGGGAGGCACAACCAACTGCGTGCCGTCCTCCAGTTGCAGTTTGTCGGTCATCAACATA
CGCACTTCGTACGCGAGGACTTTATTAAACTGCTGGAGGCTCGGCAAAATCGCGAAGTTCAGCACCACCA
GATAAGTCGTCACCAGGCTGGCGAACAGCAAGGTGACGATGAGCAATAACGTACGGGCAAATGAACTTCG
TGGCGAGAAGCGCAATCGCCTCA
Protein Sequence 
>gi|24114667|ref|NP_709177.1| osmolarity sensor protein [Shigella flexneri 2a str. 301] MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: envZ insertion mutant is able to invade cells but has decreased virulence due to the inability to survive intracellularly (Bernardini et al., 1990).
COG COG0642T, under T: Signal transduction mechanisms
References
Bernardini et al., 1990: Bernardini ML, Fontaine A, Sansonetti PJ. The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri. Journal of bacteriology. 1990; 172(11); 6274-6281. [PubMed: 2121709].