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iucD from Shigella flexneri 2a str. 301

Victor ID 877
Gene Name iucD from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1026141
NCBI Protein GI 24114947
Locus Tag SF3718
Protein Accession NP_709457.1
Other Database IDs UniProtKB-ID: Q9XCH1_SHIFL
UniRef100: UniRef100_Q0SYK4
UniRef90: UniRef90_P11295
UniRef50: UniRef50_P11295
UniParc: UPI000000E790
EMBL: AF141323
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAD44749.1
EMBL-CDS: AAN45164.1
EMBL-CDS: AAP19031.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
EnsemblGenome: EBESCG00000087661.
EnsemblGenome_TRS: EBESCT00000088617
EnsemblGenome_PRO: EBESCP00000085439
EnsemblGenome: EBESCG00000090525.
EnsemblGenome_TRS: EBESCT00000091481
EnsemblGenome_PRO: EBESCP00000088117
Taxonomy ID 198214
Gene Starting Position 3825260
Gene Ending Position 3826597
Gene Strand (Orientation) +
Protein Name lysine:N6-hydroxylase
DNA Sequence 
>gi|24111450:3825260-3826597 Shigella flexneri 2a str. 301, complete genome
CATGAAAAAAAGTGTCGATTTTATTGGTGTCGGGACAGGGCCATTTAATCTCAGCATTGCTGCATTGTCA
CATCAGATCGAAGAACTGAACTGTCTCTTCTTTGACGAACATCCTCATTTTTCCTGGCATCCGGGTATGC
TGGTACCGGATTGTCATATGCAGACCGTCTTTCTGAAAGATCTGGTCAGTGCAGTTGCACCTACAAATCC
CTACAGCTTTGTTAACTATCTGGTGAAGCACAAAAAGTTCTATCGCTTCCTTACAAGCAGGCTACGTACA
GTATCCCGTGAAGAGTTTTCTGACTATCTCCGCTGGGCTGCTGAAGATATGAATAACCTGTATTTCAGTC
ATACCGTTGAAAATATTGATTTCGACAAAAAAAGTCGATTGTTTCTGGTTCAGACCAGTCGGGGAGAATA
TTTTGCCCACAATATCTGCCTTGGTACAGGAAAACAACCTTATTTACCACCCTGTGTGAAGCATGTGACA
CAATCCTGTTTCCATGCCAGTGAAATGAATCTTCGTCGGCCGGACCTGAGTGGAAAACGGATAACCGTGG
TTGGTGGAGGACAGAGTGGTGCAGACCTGTTCCTTAATGCATTACGCGGGGAATGGGGAGAAGCGGCGGA
AATAAACTGGGTCTCACGGCGTAATAATTTTAACGCACTGGATGAGGCTGCTTTTGCTGATGAGTATTTT
ACACCTGAATATATTTCAGGCTTCTCCGGACTGAAGGAAGATATTCGCCATCAGTTACTGGATGAGCAGA
AAATGACATCGGATGGCATCACTGCCGATTCTTTACTGACCATTTATCGTGAGTTGTACCACCGTTTTGA
AGTTCTGAGAAAACCAAGAAATATCCGTCTGCTACCCAGTCGCTCGGTAACAACTCTGGAAAGTAGTGGT
CCGGGCTGGAGGTTATTGATGGAACATCATCTGGATCAGGGCAGAGAGAGCCTGGAAAGTGATGTGGTGA
TTTTCGCCACAGGTTACCGTTCTGCATTGCCACAAATACTTCCCTCACTGATGCCCTTGATCACCATGCA
CGATAAGAACACCTTTAAAGTGCGTGATGACTTCACTCTGGAATGGAGTGGCCCGAAAGAAAATAACATC
TTTGCGGTCAACGCCAGCATGCAAACTCATGGCATCGCCGAACCCCAGCTCAGCCTGATGGCCTGGCGAT
CTGCACGTATTCTTAATCGCGTACTGGGGCGTGATTTATTCGATCTCAGTATGCCGCCCGCACTGATTCA
GTGGCGCAGCGGCAGCCGGAAAAAACCACAGCCGGAGGCTGCTTCTTTAACTCACTATACAGCAAATATT
CAGGAATA
Protein Sequence 
>gi|24114947|ref|NP_709457.1| lysine:N6-hydroxylase [Shigella flexneri 2a str. 301] MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVKHVTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: iuc mutants are attenuated in chicken embryos and rabbit ileal loops (Wyckoff et al., 2009).
COG COG3486Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Wyckoff et al., 2009: Wyckoff EE, Boulette ML, Payne SM. Genetics and environmental regulation of Shigella iron transport systems. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2009; 22(1); 43-51. [PubMed: 19130265].