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aroD from Shigella flexneri 2a str. 301

Victor ID 870
Gene Name aroD from Shigella flexneri 2a str. 301
Sequence Strain (Species/Organism) Shigella flexneri 2a str. 301
NCBI Gene ID 1024864
NCBI Protein GI 24113082
Locus Tag SF1723
Protein Accession NP_707592.1
Other Database IDs UniProtKB-ID: AROD_SHIFL
UniRef100: UniRef100_Q0T478
UniRef90: UniRef90_A7ZMF8
UniRef50: UniRef50_Q186A6
UniParc: UPI000000E275
EMBL: AE005674
EMBL: AE014073
EMBL-CDS: AAN43299.1
EMBL-CDS: AAP17187.1
RefSeq_NT: NC_004337.1
RefSeq_NT: NC_004741.1
HSSP: P24670
EnsemblGenome: EBESCG00000085082
EnsemblGenome_TRS: EBESCT00000086037
EnsemblGenome_PRO: EBESCP00000082859
EnsemblGenome: EBESCG00000091574
EnsemblGenome_TRS: EBESCT00000092530
EnsemblGenome_PRO: EBESCP00000089166
GenomeReviews: AE005674_GR
Taxonomy ID 198214
Gene Starting Position 1757553
Gene Ending Position 1758311
Gene Strand (Orientation) +
Protein Name 3-dehydroquinate dehydratase
DNA Sequence 
>gi|24111450:1757553-1758311 Shigella flexneri 2a str. 301, complete genome
AATGAAAACCGTAACTGTAAAAGATCTCGTCATTGGTGCGGGCGCACCTAAAATCATCGTCTCGCTGATG
GCGAAAGATATCGCCCGCGTGAAATCCGAAGCTCTCGCCTATCGTGAAGCGGACTTTGATATTCTGGAAT
GGCGTGTGGACCACTTTGCCGACCTCTCCAATGTGGAGTCTGTCATGGCGGCGGCAAAAATTCTCCGTGA
AACCATGCCAGAAAAACCGCTGCTGTTTACCTTCCGCAGTGCCAAAGAAGGCGGCGAGCAGGCGATTTCC
ACCGAGGCTTATATTGCTCTCAATCGTGCAGCCATCGACAGCGGCCTGGTTGATATGATCGATCTGGAGT
TATTTACCGGCGATGATCAGGTCAAAGAAACCGTCGCCTACGCCCACGCGCATGATGTGAAAGTTGTCAT
GTCCAACCATGACTTCCATAAAACGCCGGAAGCCGAAGAAATCATTGCCCGTCTGCGCAAAATGCAGTCC
TTCGACGCCGATATTCCTAAGATTGCGCTGATGCCGCAAAGTACCAGCGATGTGCTGACGTTGCTTGCCG
CGACCCTGGAGATGCAGGAGCAGTATGCCGATCGTCCAATCATCACGATGTCGATGGCAAAAACTGGCGT
AATTTCTCGTCTGGTTGGTGAAGTATTTGGCTCGGCGGCAACTTTTGGTGCGGTAAAAAAAGCCTCTGCG
CCAGGGCAAATCTCGGTAAATGATTTGCGCACGGTATTAACTATTTTACATCAGGCATA
Protein Sequence 
>gi|24113082|ref|NP_707592.1| 3-dehydroquinate dehydratase [Shigella flexneri 2a str. 301] MKTVTVKDLVIGAGAPKIIVSLMAKDIARVKSEALAYREADFDILEWRVDHFADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLVGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: aroD deletion led to attenuation in HeLa cells and monkeys (Kärnell et al., 1993).
COG COG0710E, under E: Amino acid transport and metabolism
References
Kärnell et al., 1993: Kärnell A, Cam PD, Verma N, Lindberg AA. AroD deletion attenuates Shigella flexneri strain 2457T and makes it a safe and efficacious oral vaccine in monkeys. Vaccine. 1993; 11(8); 830-836. [PubMed: 8356844].