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gcvT

Victor ID 755
Gene Name gcvT
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192518
NCBI Protein GI 56707556
Locus Tag FTT0407
Protein Accession YP_169452.1
Other Database IDs UniProtKB-ID: GCST_FRATT
UniRef100: UniRef100_Q14J42
UniRef90: UniRef90_Q14J42
UniRef50: UniRef50_A3MQP5
UniParc: UPI0000450176
EMBL: AJ749949
EMBL-CDS: CAG45040.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG299834
OMA: KALYGGM
ProtClustDB: PRK00389
Taxonomy ID 177416
Gene Starting Position 413779
Gene Ending Position 414855
Gene Strand (Orientation) +
Protein Name glycine cleavage system aminomethyltransferase T
DNA Sequence 
>gi|56707187:413779-414855 Francisella tularensis subsp. tularensis Schu 4, complete genome
CATGCTGAAAACTCCTCTTTATGAATCACATATGGCAGCAAATGCTAAGATGGTTGATTTCTCAGGCTGG
TCAATGCCAATTAACTATGGTTCACAAATTCAAGAGCATAATAATGTTAGAGAAGATTGTGGTATTTTTG
ATGTATCACATATGTTAGCAGTTGATATTCAAGGTTCTGAAGCTGAGAAGTTTTTACGCTATCTTTTAGC
CAATGATGTTGCTAAATTACAGGAGAATAAAGCTCAATATGGCTGTATGTTAAATCATGATGCTGGTATT
GTTGATGATTTGATTACTTATAAAGTTACAGATGAGCATTTTAGAATAGTTGTCAATGCTGGTAATAGAG
AGTCAGATGTTGCATGGTTTAATCAAAATGCTCAAAATTTTGATGTTGCGATAACCCCACAGACTGATTT
AGCTATAGTTGCAGTACAGGGACCAAAAGCTGTTGCCGTTATTAAGCGTGTTGTTACCAAAGAAATTGCT
ACTGAAATTGAAGCGCTATTGCCTTTTTCATTTAAGTTTTTTAGTAAATGGATGGTAGCACGTACTGGTT
ATACTGGTGAAGATGGTTTTGAGGTGATTCTCCCTGCAACACAGGTCAAAAAATTCTGGGATAGTCTGCT
TGAAAATGGAGCACAACCTGCAGGGTTAGGCGCTCGTGATACATTAAGATTAGAAGCTGGGATGCATCTA
TATGGTGCTGATATGGATACCTCTACGACACCGCTAGAAAGAGGCTTGGGCTGGAGCGTTGATTTATCTG
ACGAACATAGGGACTTTATTGGTAAGAAAGCATACTTTGCTAAAAAAGCACAAGGAGTTGATACTAAATG
GGTCGGTGTAGTACTAAAAACAAAAGGTGTCCTTAGAGCAGGTCAAGAAATTGATTTTGATAATGGTGAA
AAAGGCTATATAACCAGTGGGAGTTTTTCACCAACTTTGAAAGTAGCTATTGGATTAGCTTATGTGCCTA
AGCAAGCTGATAATCCTGTGGTAAATATTAGAGGTAAGGAGCTCGAAGTCGAGCTAGTTAAACCTAAGTT
TGTTAAAAATGGTAAATCTTTGATATA
Protein Sequence 
>gi|56707556|ref|YP_169452.1| glycine cleavage system aminomethyltransferase T [Francisella tularensis subsp. tularensis SCHU S4] MLKTPLYESHMAANAKMVDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENKAQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTKEIATEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDTSTTPLERGLGWSVDLSDEHRDFIGKKAYFAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAIGLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gcvT mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0404E, under E: Amino acid transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].