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gcvP1

Victor ID 752
Gene Name gcvP1
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192502
NCBI Protein GI 56707558
Locus Tag FTT0409
Protein Accession YP_169454.1
Other Database IDs UniProtKB-ID: GCSPA_FRATT
UniRef100: UniRef100_Q14J40
UniRef90: UniRef90_B0TZJ6
UniRef50: UniRef50_Q3SMB8
UniParc: UPI0000450169
EMBL: AJ749949
EMBL-CDS: CAG45042.1
RefSeq_NT: NC_006570.2
HSSP: Q5SKW8
GenomeReviews: AJ749949_GR
HOGENOM: HBG288345
OMA: VTEKRTK
ProtClustDB: PRK00451
Taxonomy ID 177416
Gene Starting Position 415358
Gene Ending Position 416725
Gene Strand (Orientation) +
Protein Name glycine dehydrogenase subunit 1
DNA Sequence 
>gi|56707187:415358-416725 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGTCTTTTATCCCGCATAAACTAGAACAAATCAAAAAAATGCTTGATACTATAGGAGCTAGTTCTGTA
GATCAGTTATTTGATGAGATTCCAAGACACTTAAGGGCTGATACTCTTAAGATTAAAGATGGTATCAATG
AGATTCAATTAGCAAATCTTATGAGAAAGAGAGCTAATAAAAATCATCATAATATAAATTATATAGGTGC
TGGTGCCTATAGTCACCATATTCCAGCTGCGATATGGGATATCGTAGCTCGTGGCGAGTTCTATACTGCA
TATACACCATATCAAGCAGAGGCTTCACAAGGTGGTTTGCAAGTTATCTATGAATTTCAAACTATGATGG
CAGGGCTAACAGGTATGGATGCCTCAAATGCGTCTATGTATGATGGCGCAACTGCTTTAGCCGAGTCGGT
ACTTATGGCGATTCGCTCAAACAAAAAAGCAAAGTCACAAAAGGTTTTGATTGCTGAAGCTTTACACCCA
ACTTATTTGAGAGTATTAGAAACTATAACAAAGCATCAAGGTATAGAGTTTGATATTGTTAATCTTGATT
CTAAAAATGGTAAGACAGACGTTACAAAGTTAGAAGATTTTGCTAATACCAATTATGCAGCTGTAGTTAT
CCAAAGTCCTAATTTCTTAGGTCAACTTGCAGATGTTGATGGGATTACAAATTGGGCACATAAGCATGGA
GCTTTGGTTATTGCAGTTACTAATCCTATGTCGCTTGCAATATTAAAATCACCAGCGGAATGGGGTGATA
ATGGTGCTGATATAGTATGTGGTGAGGGTCAACCTATGGGTGTGCCTTTAGCTTCTGGAGGTCCATATTT
TGGTTTTATGACTTGTAAGATGGCTCATGTACGTCAAATGCCAGGGCGTATAGTTGGTAGAACTGTTGAT
TTAGATGGAAATGAAGGTTTTTGTTTGACGCTACAAGCAAGAGAACAACATATCCGTCGCGCTAAAGCTA
CTTCAAATATCTGTACTAACCAAGGCTTGATGGTTACAGCGGCAACTATTTATATGAGCTTACTAGGTGC
TGAAGGTTTAGAAAGAGTAGCTAGTATTTCTCATGAAAATACACAAACTTTAGCGACTGAATTAGCTAAA
ATAAACGGGGTAAGCATTAGATTTAATAGTGCTTTCTTTAATGAAGTAGTAATCGATTTACCTGTAAATG
CTGAAACTTTTGTAACAGAGATGGAAAAAGAAGCTATTGATGCAGGTTACTTTTTAGGGGAATATCATAG
TGATTTAGCTAACTCTATTATGGTTTGTGCTACAGAGATTCATACATCTGAAGATATCAAAGAGTATATA
GAAGCTACTAAAAAAGTTTTAGCTAGGATAGGAGGTTA
Protein Sequence 
>gi|56707558|ref|YP_169454.1| glycine dehydrogenase subunit 1 [Francisella tularensis subsp. tularensis SCHU S4] MSFIPHKLEQIKKMLDTIGASSVDQLFDEIPRHLRADTLKIKDGINEIQLANLMRKRANKNHHNINYIGAGAYSHHIPAAIWDIVARGEFYTAYTPYQAEASQGGLQVIYEFQTMMAGLTGMDASNASMYDGATALAESVLMAIRSNKKAKSQKVLIAEALHPTYLRVLETITKHQGIEFDIVNLDSKNGKTDVTKLEDFANTNYAAVVIQSPNFLGQLADVDGITNWAHKHGALVIAVTNPMSLAILKSPAEWGDNGADIVCGEGQPMGVPLASGGPYFGFMTCKMAHVRQMPGRIVGRTVDLDGNEGFCLTLQAREQHIRRAKATSNICTNQGLMVTAATIYMSLLGAEGLERVASISHENTQTLATELAKINGVSIRFNSAFFNEVVIDLPVNAETFVTEMEKEAIDAGYFLGEYHSDLANSIMVCATEIHTSEDIKEYIEATKKVLARIGG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gcvP1 mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0403E, under E: Amino acid transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].