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hisS

Victor ID 741
Gene Name hisS
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192430
NCBI Protein GI 56707231
Locus Tag FTT0052
Protein Accession YP_169127.1
Other Database IDs UniProtKB-ID: SYH_FRATT
UniRef100: UniRef100_Q14K18
UniRef90: UniRef90_Q14K18
UniRef50: UniRef50_B0TWR5
UniParc: UPI0000450192
EMBL: AJ749949
EMBL-CDS: CAG44685.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG616575
OMA: VFEWVTT
ProtClustDB: PRK00037
Taxonomy ID 177416
Gene Starting Position 53681
Gene Ending Position 54946
Gene Strand (Orientation) +
Protein Name histidyl-tRNA synthetase
DNA Sequence 
>gi|56707187:53681-54946 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGAGTAAGCTTACTATTGTTCGTGGATTTAATGATGTATTGCCACTAGACAGTTATAAATGGCAACTC
TTGGAATCAAAAGTAAAACTCATACTTGATAGATATAACTACAGTGAAACAAGATTGCCTATTGTTGAGA
GGAGCGAATTGTTTCATAGAAGTGTAGGTGAAAGTTCTGATATAGTTTCAAAAGAGACTTATGACTTTCA
AGATCGTAATGGTGATAGCCTGACATTGCGTCCAGAAGGAACAGCTGGCTGTGTTAGGATGGTTATTGAA
AATAATTTGGCTACTCGAGGCCAAACACAGAAACTATGGTATTGTGGACCTATGTTTCGCTATGAGCGCC
CACAAAAAGGCCGCTATAGACAATTTTATCAGCTTGGGGTTGAGGCTTATGGCTTTGATGGTATAGCTAT
TGATTTAGAGGTTATTGCTATAGCTTGGAGTCTTTTCAAAGAGCTTGGGATTTATGAGTATGTAACTTTA
GAACTAAATAGCCTTGGTTCTAGTCTTAACAGACAAGAGTATACTCAAGCGCTATTACAATACCTAAAAC
CATATCATGCTGAGCTTGATGAAGATTCTATCAAGAGGTTGGATAAAAATCCTCTAAGAATATTAGATTC
TAAGATAGAAAAAACACAAAAAATCTTAGCAAACGCACCTAAACTTATTGATTTTATAGATCATGATTTG
CGTTTGAGATTTAAACAAACTTGTCAATATTTAGATGCCTTGGGTGTCAGATATAAATTAAATGAAAATC
TTGTTAGAGGTTTGGATTATTATACTGGTTTAGTTTTTGAATGGACTACTGATAAACTTGGTTCACAGAG
TGCAATCTGTGCAGGTGGTCGTTATGATGGTCTTGTAGAGAATCTTGGTGGTCAGAAAACTGCTGCGATA
GGATTTGCTATAGGTATGGAGCGTTTGTTACTCTTATTAGAAGATTTAGGTAAATTACCTAATCAAGATA
ATGCTTGTGATGTGTTTTTCATATTAGATAGTGCCCAGCTGCATCAATCTCTTGCTATAGTAGAGAATAT
TCGCCAAGAGCTTCCCCAACTTAAAATAGATATGGATCTAAAGTTTGGTAGTTTTAAATCACAATTTAAG
AAAGCGGATAAATCTGGAGCTAAAGTTGCTATAATAATCGGCCAAGATGAGTTAGATAATGGCTTTGCTG
GTATAAAATTTCTTCAACAAAATGAAGAACAACAACAAGTTGCTTTTAATGAGTTAATAAATTTTTTAGA
AAGATA
Protein Sequence 
>gi|56707231|ref|YP_169127.1| histidyl-tRNA synthetase [Francisella tularensis subsp. tularensis SCHU S4] MSKLTIVRGFNDVLPLDSYKWQLLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGIYEYVTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQTCQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVENLGGQKTAAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLER
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hisS mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0124J, under J: Translation, ribosomal structure and biogenesis
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].