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bioA

Victor ID 732
Gene Name bioA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192333
NCBI Protein GI 56708035
Locus Tag FTT0938
Protein Accession YP_169931.1
Other Database IDs UniProtKB-ID: Q5NGB1_FRATT
UniRef100: UniRef100_Q14HR3
UniRef90: UniRef90_Q14HR3
UniRef50: UniRef50_A0Q639
UniParc: UPI000049C3FB
EMBL: AJ749949
EMBL-CDS: CAG45571.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG725944
OMA: FACEQAN
ProtClustDB: CLSK986238
Taxonomy ID 177416
Gene Starting Position 949384
Gene Ending Position 950715
Gene Strand (Orientation) +
Protein Name Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
DNA Sequence 
>gi|56707187:949384-950715 Francisella tularensis subsp. tularensis Schu 4, complete genome
TGTGTACAATTTATGTCAACTTAATATTTTACAAAAGGTTTACAATATGTATAGCTCAAACATATGGCAT
CCATGCACACAAATGAAAGACTTTGAAAAATCTCCACCTTTGAATGTTTATAGAACGGAAGGGCGATATA
TCTACACTAAAGATAATAGAAAGCTTTTTGATGCTACTTCAAGTTGGTGGTGTAAATCTCTTGGACATAG
ACATCCATACATAATAGATAAGCTTAAAAAACAACTAGATAAATATGAGCATACGATATTTGCAAATGCT
ACAAATGATGAAATAGATAGGTTTAGTCAAAGAATTTGTAATTTGACAGGTATGGATAAAACTTTATACG
CAAGTGATGGATCTTGTGCTGTAGAGATAGCTCTAAAGATGACAATACACCTTAGAAGCTTTCAAAATCA
AACTAAAAAAATTAAGTTTGTATGCCTTGAAAACTCATATCATGGTGAGACTTTAGCAACTATGAGTGTC
AGTGATTGTGGTTTATATTCCGATCCATATAAACCATTATTATTTGATAGTTTTAAGCTAAAAAATATTC
CCTATGTTACTGGCAAAAATGATCCGCTATGGGCAAATGCTGAAAGGTATTGGAATAAATCACAACAATA
TCTTGAGCAACACAAAGAATTTATTAATGCTTTAATAGTAGAGCCAATCTGCCAAGGTGCTGGGGGTATG
TTGATTTATAGCAAAGATTATTTAAATATACTTTGTAAGTGGTGTAAGGAAAATGATATTTATATTATTT
TTGATGAGATAATGACTGGACTAGGGCGATTGGGTAAACTTTTTGCTTATGAATATCTAGATATCACGCC
TGATTTTTTGTGTGTATCAAAAGGGCTAACCTCTGGGATTATACCTTTTAGTATTGTTTTGACAAAAAAT
CAATATTATGAGATGTTTTATGATGATCAGTTAACTAAAGCCTTTTTACATTCACATACTCATAGTGGTA
ATGTTTTAGGAGCTGTGGTAGCAAATGCAGTATTAGATATATTTGAAGAAGAAAATATACTTACTAATGT
TAAAGATCTCGAAAAACAATTTAGTGAATCTTTTCTTGAGCTACAAGAGCAATTACCTATTATAAAAAAC
GTTAGAGGTATTGGAGCAGTTATCGCAGCAGATTTAAATATTGATAAAAAAAGAGCTGGCTTAGATGTCT
ATCGAGAAGCTATAAAATTAGGCGCATTATTAAGACCACTAGGAAATACTATCTACTGGCTACCACCATT
CAATAGTACTTATCAAGAGATTGATTTATTAAAGCAAATCACAAAACAGTCAATTATAAATGCTTTTAAA
TA
Protein Sequence 
>gi|56708035|ref|YP_169931.1| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Francisella tularensis subsp. tularensis SCHU S4] MYNLCQLNILQKVYNMYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYIIDKLKKQLDKYEHTIFANATNDEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLRSFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKPLLFDSFKLKNIPYVTGKNDPLWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYIIFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLTKAFLHSHTHSGNVLGAVVANAVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVRGIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIYWLPPFNSTYQEIDLLKQITKQSIINAFK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: bioA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0161H, under H: Coenzyme transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].