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lysA

Victor ID 730
Gene Name lysA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192305
NCBI Protein GI 56707207
Locus Tag FTT0027c
Protein Accession YP_169103.1
Other Database IDs UniProtKB-ID: Q5NIN9_FRATT
UniRef100: UniRef100_Q14K42
UniRef90: UniRef90_A7NEL4
UniRef50: UniRef50_A0Q8H6
UniParc: UPI000049C19B
EMBL: AJ749949
EMBL-CDS: CAG44660.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG485574
OMA: PLCMNID
ProtClustDB: CLSK934337
Taxonomy ID 177416
Gene Starting Position 25841
Gene Ending Position 27094
Gene Strand (Orientation) -
Protein Name diaminopimelate decarboxylase
DNA Sequence 
>gi|56707187:25841-27094 Francisella tularensis subsp. tularensis Schu 4, complete genome
ATTATTGATGTGTTTGTCTAACTCTGAGAACTTGGTATTGATGATTTTTGTCGATTAGAATTACACTTGG
CTTTAGATGGATGAACTCGTTATTTCTTGATATGTTATAAGCCCCAACTCCATCTATCAGTAATTTATCT
CCATATTCAAGCTTCGGTAAAAATATATCATCATGCAAAAAATCATGTTGCATACAACTAGGACCCAATA
GTAAGGTTTTCTTGTGGTAGCTATCAGTTTTTAGGTGGTAGATTGGGTGTCTATAGGTAGATATTGTTGG
TATGGTATGTATCCCAGCATCTGTTATTAAGCTTTGGAAATCTTCATTTTGCTCTCTAGTACCAACTATA
GTTGTTAATAGTGCTACTGAATAATCGACCAAACTACGTCCTAGCTCAAAAATTAATTTAGTTTTATCAT
TGGTTTTGTTTAAATACTCTTTTAGGGGGGCTATTATTGTCGCGGCATATAGTTCTAAATCAAAAGGGTT
GTATGGTTGTAATCTTTTATCGCTTAGAGTAGGGCTTATTCCCGCTAAACCGCCACCTAAGTCTATCCAT
TCTAGAGTAAGTTTATACTTTGTTAGAATCGTCTCGGCCAATTCGGCAATGTTTTTTGCCATTGCGGTAA
ATCTCGAGATATCTCTAATATTTGTTCCAATATGACAATGTAGCCCAGCTAATTGAATATTTGCTATTTG
TTGTATTTTGTCTATGGTGGTAAATATATCACTATTACTTTGTTGGTCTGTTAAGGCAAATCCAAATCTA
GACCAATTTTGAGGAGTTTTATTATCTGCTACTCTTAAACCAATTTTTGCAGTTATATTTAGCTTTTTTG
CGATCTTTGCAATGCGCAATATTTCATCAAAGTGATCACAGTTTATCATAGCATTTAATTGTAATGCTTT
GATTAAGCTTGCATCATTTTTATATGGACCATTAAAGATTATACTTTTATCACATAGTTGTAGTTTTTGT
ATTTGCTCAAACTCATCACTCGAGACAACCTCTGGGATAAATCCTACTTCATAAAATTTTTGAATAATAG
TGTTTAGAGATTGAGTTTTTACTGAGTATGCGGCAATACTATTTTGATATTGATTTAAAATAGCTTGTTG
AAAAAGTCTAGCTCGTTCTAGCAGCGCATTTTCATCGATGATAAAGCATGGCGAAGCATATCTTTGAATA
ATTGTTTCAATTTGTTTGTTTGAAAGTTTACTAAAAACACTCTTTGAATCGCTTAGTTTAGACA
Protein Sequence 
>gi|56707207|ref|YP_169103.1| diaminopimelate decarboxylase [Francisella tularensis subsp. tularensis SCHU S4] MSKLSDSKSVFSKLSNKQIETIIQRYASPCFIIDENALLERARLFQQAILNQYQNSIAAYSVKTQSLNTIIQKFYEVGFIPEVVSSDEFEQIQKLQLCDKSIIFNGPYKNDASLIKALQLNAMINCDHFDEILRIAKIAKKLNITAKIGLRVADNKTPQNWSRFGFALTDQQSNSDIFTTIDKIQQIANIQLAGLHCHIGTNIRDISRFTAMAKNIAELAETILTKYKLTLEWIDLGGGLAGISPTLSDKRLQPYNPFDLELYAATIIAPLKEYLNKTNDKTKLIFELGRSLVDYSVALLTTIVGTREQNEDFQSLITDAGIHTIPTISTYRHPIYHLKTDSYHKKTLLLGPSCMQHDFLHDDIFLPKLEYGDKLLIDGVGAYNISRNNEFIHLKPSVILIDKNHQYQVLRVRQTHQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lysA mutant is attenuated in mice (Weiss et al., 2007).
COG COG0019E, under E: Amino acid transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].