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manB

Victor ID 728
Gene Name manB
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192273
NCBI Protein GI 56708489
Locus Tag FTT1447c
Protein Accession YP_170385.1
Other Database IDs UniProtKB-ID: Q79RC1_FRATT
UniRef100: UniRef100_Q14GG0
UniRef90: UniRef90_A7NAW7
UniRef50: UniRef50_A0Q7S1
UniParc: UPI000034E337
EMBL: AY101577
EMBL: AJ749949
EMBL-CDS: AAS60281.1
EMBL-CDS: CAG46080.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG644964
OMA: RCYAEAD
ProtClustDB: CLSK935036
Taxonomy ID 177416
Gene Starting Position 1495185
Gene Ending Position 1496669
Gene Strand (Orientation) -
Protein Name Phosphomannomutase
DNA Sequence 
>gi|56707187:1495185-1496669 Francisella tularensis subsp. tularensis Schu 4, complete genome
TTCAAATGTTTTTGTTAATCAAATCCACACAATATTGATTTAAACTTTTTGCCTGCTCATCACTAGCTGC
CTCTGTATAGCACCTAAGCTCTGGAGCATTACCAGATGGTCTAAGATGGATAATATCTTGATTTGTCAAA
GTTACTCTAACACCATCTGTAGTATCGATATTTTCAATGCTATTTTTACCATCAAAATGCTCCGATATAA
TTTTATCTAAAAGATCTGATTCACCTGCTAATATTGACTTCAAGATTTCTTGGCTTTTCTCGGAAGCAAA
ATCATCAATTTTACTACTTGCTGTATATCGAGATGGCAAATCAAATAAAAGCTCTGACACGGTTTTATTA
GAGTTGATAGATAGCATCATTACAGCCAACATTGGTATAACAGCATCTCTTGTAGGCAGCGCTTTTAGAG
TTTTATCATCTTTACAAATATCACTAGCCAATAGAAATCCTCCATTTGCCTCATATCCAACCACAGCATT
TTGATTATTTGAGAGTAATTCATTCATTGCAGCAATTACATACGGCGAGCCTATTTTAGTTCTAATCACG
TTACTAAAATAACCTATCTTTTCTGCCACAGTATTGCTACTTACTGGTGTCACGATAACATTGGCTTGGA
GATATTTAGCTGTCAGTACACCTAAAATATCACCTTTTAGCCAATTGCCATACTCATCACTAACTAGTGG
CCTATCAGCATCGCCATCAGTTGAAACTATACTATCAACTTTATACTTGCTTGCCCACTGCTTAGCAAGC
TTTACATCTTCCTGGCGAATTGCCTCGGTATCTACAGATACAAATTTTTCGGAAAATTCTAGCAAGATAA
CCTTAGCACCTAGTTTCTCTAGAATCTCTTTGACTATCTCTCGTCCTACAGATGAGTGCTGATAAAGCCC
TATAGTCTTACCTGCTAGACAGTTGTTAGGGAAAAAATCTACATACCTGTCAATATACTGTGTATATGCT
TGCTTACTAGGCTCTGGTAATTCTAGTTTTTGTAAAAACATGCCATTTTTATCAAAAATACTTTCATCAA
TGCTGATAGTTTGGCTAACAATCATTTCTTCATCTTCTTTGAGAACTTCACCATATGGAGTATTAAACTT
AATACCATTTCTATCCTCTGGAATATGACTACCAGTAACCATAACTGACGGTATCTGATTAGATATACCA
TATAGCATTACAGCTGGTGATGGTATCTCACCACAGTATATTGGCTCATGACCACTATCTATGATAGCTT
TAATAACAACTGTTGTTATTCTAGGGCTACTCTCACGTAGATCATGAGCTATAGCAATTTTAGTACCCTT
AGCAATAGAGTATTTTTGCTCTAGGAATTGAATAAAAGCTTTTGTATAAAGCCAACAGATCTTATCTGTC
ATAGCTGAAACAAGACCTCTAACTCCACTAGTACCAAACTTTACGCCGCTAGATTTGATTATTTCTTTTA
TTATAGTTTGTCTCA
Protein Sequence 
>gi|56708489|ref|YP_170385.1| phosphomannomutase [Francisella tularensis subsp. tularensis SCHU S4] MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIAHDLRESSPRITTVVIKAIIDSGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRNGIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQKLELPEPSKQAYTQYIDRYVDFFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKLAKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLTAKYLQANVIVTPVSSNTVAEKIGYFSNVIRTKIGSPYVIAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKALPTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKIDDFASEKSQEILKSILAGESDLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAKSLNQYCVDLINKNI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: manB mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG1109G, under G: Carbohydrate transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].