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xasA

Victor ID 709
Gene Name xasA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192117
NCBI Protein GI 56707622
Locus Tag FTT0480c
Protein Accession YP_169518.1
Other Database IDs UniProtKB-ID: Q5NHH4_FRATT
UniRef100: UniRef100_Q14IX6
UniRef90: UniRef90_A7NDU0
UniRef50: UniRef50_A0Q5F1
UniParc: UPI000049C2CF
EMBL: AJ749949
EMBL-CDS: CAG45113.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG514881
OMA: MANIKQA
ProtClustDB: CLSK934531
Taxonomy ID 177416
Gene Starting Position 498403
Gene Ending Position 499812
Gene Strand (Orientation) -
Protein Name Glutamate:gamma-aminobutyric acid antiporter family protein (APC family protein)
DNA Sequence 
>gi|56707187:498403-499812 Francisella tularensis subsp. tularensis Schu 4, complete genome
TTTATTTTTTAATGGTTATAACTGCTGGAATAATTAGTGTAATAACAATTCCTACAATAAGCATCATGTC
AAAATTAAAAACTGACATTGCCATATTGTCTATAGGAATAAATCCGACAATTATCGCTACTAAACAGCCA
AAACAACCTAGTAATGCCATTAGAATAGTTCCAAAAGAACCCTTACATATTTCATATTGATCTTCTTCAA
GTGGTGAGCTAATTTTTAGTTTTACAGCCGTAATAAACATCAAGATATATGCTATAACCGCTAACTGTGC
AGTTAAATCACTAAGATACCAATATGCTTCATTTACTGATGGCATAAATATATATGAGAAGCAAAATACT
GTAAAAACAAGTGCTTGGGTAATAAGCATAGTATCAGGAGCATCATTTTTATTTGTCCTACCAAATATTT
GTGGCAAGATGTTGTCATTACTAACAACCATAAAAGCTCTAGATAATCCCATAATCCAAGCTGATGTTGT
TGTAAATGCACCAAATATCAGCGTTACTGCGATTATATAAGTCATCCATGGCATATTAATCTGACTAAAG
AAGTAGTGGAAAGAAACCATTAGACCTGTAACTATATCAACATCACCAATCTGTAACTGGCTACTTACTA
ATATCACCGCAATATTTGATAAAATCAAAGATCCTAATATTACAGAACCTGAAATTAGGAGGGCACGAGG
AAAATTTTTCTTAGCATTTTTGACATTTGCTGCATGTATAGCACTCATTTCTAAACCGAAAAGGCTAAAC
ATCACAGTTATAAATAAAGCCCAGCTACTGATATTATTACCCGATGGAATAAAATCAGAAATTTTTGGCG
CAACAATTTCAGCAGTATGAGACATCGACCATATTATTGCTATTATTATGATAATAAACATTGGTAAAAG
TGTACCAATAATAGCTCCAAGTGTACTTACAGTACTTGATGTTTTGATACCAAATAAGTTAATTGCGGTG
GCACTCCAAAACATTACTAAACTCATTGATATCATATACCAAGGATTAGCAACTAAGTGATTAGCATCTT
GTCCGGTCAAAGGTGCTATGACATAAGCAATAACTCCAGCGAAGAATCCACAAATAGATGGAAACCAAAC
TAAGTTGTAAACCCACTGTAACCAGATAACCAAAAATCCTAGTCTTTTGCCAAATGCTTTTTTAACCCAG
ATATAGATACCACCATTCTCTTGTGAGGAGCCGGTAGACATTTCTGCGGTTAGTAGCGCACACGGAATCA
AGAAGAAAATTCCAGCTAAAATATAGAAAGTTATAACGATCCAACCTGCTTGAGCCGTTATAGAGATATT
TCTTAAGCTATCGACAGCGATAATATTTATCATTATTAGTCTGATAAGACCAAATTTTTTACTACTAATA
ATTTGTTCCA
Protein Sequence 
>gi|56707622|ref|YP_169518.1| glutamate:gamma-aminobutyric acid antiporter family protein [Francisella tularensis subsp. tularensis SCHU S4] MEQIISSKKFGLIRLIMINIIAVDSLRNISITAQAGWIVITFYILAGIFFLIPCALLTAEMSTGSSQENGGIYIWVKKAFGKRLGFLVIWLQWVYNLVWFPSICGFFAGVIAYVIAPLTGQDANHLVANPWYMISMSLVMFWSATAINLFGIKTSSTVSTLGAIIGTLLPMFIIIIIAIIWSMSHTAEIVAPKISDFIPSGNNISSWALFITVMFSLFGLEMSAIHAANVKNAKKNFPRALLISGSVILGSLILSNIAVILVSSQLQIGDVDIVTGLMVSFHYFFSQINMPWMTYIIAVTLIFGAFTTTSAWIMGLSRAFMVVSNDNILPQIFGRTNKNDAPDTMLITQALVFTVFCFSYIFMPSVNEAYWYLSDLTAQLAVIAYILMFITAVKLKISSPLEEDQYEICKGSFGTILMALLGCFGCLVAIIVGFIPIDNMAMSVFNFDMMLIVGIVITLIIPAVITIKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: xasA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0531E, under E: Amino acid transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].