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wbtH

Victor ID 707
Gene Name wbtH
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3192087
NCBI Protein GI 56708497
Locus Tag FTT1456c
Protein Accession YP_170393.1
Other Database IDs UniProtKB-ID: Q79RD0_FRATT
UniRef100: UniRef100_A4IWP6
UniRef90: UniRef90_A0Q7S4
UniRef50: UniRef50_A0Q7S4
UniParc: UPI000034E32F
EMBL: AY101577
EMBL: AJ749949
EMBL-CDS: AAS60272.1
EMBL-CDS: CAG46089.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG752912
OMA: WDARARM
ProtClustDB: CLSK935038
Taxonomy ID 177416
Gene Starting Position 1505687
Gene Ending Position 1507573
Gene Strand (Orientation) -
Protein Name asparagine synthase
DNA Sequence 
>gi|56707187:1505687-1507573 Francisella tularensis subsp. tularensis Schu 4, complete genome
TTTACTCATTATCTAACCACTCCTGAAAAATTAGAATATTCCATAATATTGCTTGCCAATTTCTTTTACC
ACTCAAATGCTCTTGCCAATATTTTTGCACCACCTCAGGACTTAAGTAACCTTGCTTGTCTATTTTACTA
TAATCCAGTAAATTATCTGCCCACTCTCGTAAATCTTCTCTTAACCATTTAGCAAGCGGAATACCAAACC
CCATCTTAGACCTATTGACCAAACTTTCTGGCACATATTTATATAACAAATCTTTCAAAATTCTTTTTCC
GTTACCTCGTTGTATTTTATAGTCAATTGGTAAGGAATAAGCAAATTCATAAATATTATGATCTAAAAAT
GGCACTCTTGTCTCTAGAGAGTTAGCCATAGCTGCTCTATCAACCTTAACCAATATATCATCTATCATAT
ATGTATTAGAATCAACAAACATCATCCACTCTTGGAAAGATAATTGTGGAATATCATAAATATTCTTATC
TCTTAATATATCATACTCTTTTGCTCCTAACACAAAGCTAGTATCATTTATTTGTGAACAAAGTAGTACA
TAAAGCTCTTTATTTGTTTTTGCTTTTTCGAGAACTCTTTTTAGTTTTAGTAGTTTATCTGCTAATAAAG
CGAACTTACCAAAATTTAATATCTCAGCTTTTTTTATCCAAGCATCTGGTGCATATTTAAGTAACTTAGC
AAATTTGATTTTTTTAGCAATATTTGGTGCTAAAAAGTATCTATTATAACCGCCAAAGAGCTCATCACCA
GCGTCACCTGATAGTGCAACTGTTACTTTCGACTTAGCTATTTTACTCACAAGATACGTTGGTATTTGTG
ATGAATCAGCAAAGGGCTCGTCATATATTCCAGCAAGTTTTGGTATTACATCAAGAGCATCTCTTTCTGT
AACATACATATCTGTGTGGTTTGTACCTATATGTTTTGCTACTGCTCTTGCATGCTCAGCTTCATTATAT
TCTTTTTGATTAAAACCTATACTAAAAGTGTTTATCTTATCTTTAGACATACTTTGCATAAGAGCAACTA
CAGTTGTTGAGTCAATTCCTCCGGATAAAAATGCTCCTAGAGGAACATCTGACTGCATTTGTATTGATAG
TGTACTTTTAAGCTTAATTTCTAAATCTAGGATTGCTTGATCATACGAATCTTTATATTTTTCTGAATCT
AGTACTTTTTTAGAATCCCAATATTTATACTCTTTACTATTACCTTTAGCATCAAATTTTATGTAACTAC
CTACATTTAGTTTAGATATATTTTTATAAATAGAGTATGGTGTTGGTACATAAGCATACCTCATATATGT
TGCTAAAGCATCTCTATCTATATCAAACCTCCAGCCACATTCCTTTAATGGCTTAAGTGCCTTCAATTCT
GATGCAAAACCCAAAATACCATTTTGGATACCAAAATATAATGGCTTCTCGCCAAATCTATCTCTAGCTA
GTATTAAGCAACTAGTTTTTCTACTGTAAACTCCAAAAGCAAACATTCCTATGCATTTTTCTAAAGTTTT
ATCTATACCCCAAAGTTCAATAGCATTGACCAAAACCTCAGTATCACTGTTACTTTTAAATTTAAGATTT
GAATATTCACTTAATAGCTGATTTTTTATGGATAAGTAATTATATATTTCTCCATTAAACACAATAGCAG
TATTACCGCTATTAGATAACATTGGCTGATGTCCCGCATTAGTTATATCGTGTATTGATAATCTAGTATG
CCCCAGAGTAACTTGATTGTCGCACCAATACCCACTATCATCCGACCCTCTATGCTTTATAGAAAGCAAT
GATTGATTAATTATTGAGTCAAAACCTTCTTCTTTATTAAATGAGTAAAAGCCTACTACTCCACACA
Protein Sequence 
>gi|56708497|ref|YP_170393.1| asparagine synthase [Francisella tularensis subsp. tularensis SCHU S4] MCGVVGFYSFNKEEGFDSIINQSLLSIKHRGSDDSGYWCDNQVTLGHTRLSIHDITNAGHQPMLSNSGNTAIVFNGEIYNYLSIKNQLLSEYSNLKFKSNSDTEVLVNAIELWGIDKTLEKCIGMFAFGVYSRKTSCLILARDRFGEKPLYFGIQNGILGFASELKALKPLKECGWRFDIDRDALATYMRYAYVPTPYSIYKNISKLNVGSYIKFDAKGNSKEYKYWDSKKVLDSEKYKDSYDQAILDLEIKLKSTLSIQMQSDVPLGAFLSGGIDSTTVVALMQSMSKDKINTFSIGFNQKEYNEAEHARAVAKHIGTNHTDMYVTERDALDVIPKLAGIYDEPFADSSQIPTYLVSKIAKSKVTVALSGDAGDELFGGYNRYFLAPNIAKKIKFAKLLKYAPDAWIKKAEILNFGKFALLADKLLKLKRVLEKAKTNKELYVLLCSQINDTSFVLGAKEYDILRDKNIYDIPQLSFQEWMMFVDSNTYMIDDILVKVDRAAMANSLETRVPFLDHNIYEFAYSLPIDYKIQRGNGKRILKDLLYKYVPESLVNRSKMGFGIPLAKWLREDLREWADNLLDYSKIDKQGYLSPEVVQKYWQEHLSGKRNWQAILWNILIFQEWLDNE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: wbtH mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0367E, under E: Amino acid transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].