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folD

Victor ID 687
Gene Name folD
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191934
NCBI Protein GI 56707993
Locus Tag FTT0892
Protein Accession YP_169889.1
Other Database IDs UniProtKB-ID: FOLD_FRATT
UniRef100: UniRef100_Q14HV5
UniRef90: UniRef90_Q14HV5
UniRef50: UniRef50_B0KLM9
UniParc: UPI000049C3DD
EMBL: AJ749949
EMBL-CDS: CAG45525.1
RefSeq_NT: NC_006570.2
PDB: 3L07
GenomeReviews: AJ749949_GR
HOGENOM: HBG328751
OMA: TYVRNKQ
ProtClustDB: PRK14180
Taxonomy ID 177416
Gene Starting Position 900247
Gene Ending Position 901095
Gene Strand (Orientation) +
Protein Name methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase putative bifunctional protein
DNA Sequence 
>gi|56707187:900247-901095 Francisella tularensis subsp. tularensis Schu 4, complete genome
AATGATTTTAATCGATGGTAAGTCTCTCTCAAAAGACCTTAAAGAGAGATTAGCAACTCAAGTTCAAGAA
TATAAGCATCATACAGCAATCACCCCAAAACTTGTCGCAATAATTGTTGGTAATGATCCGGCAAGTAAGA
CATATGTTGCCTCAAAAGAAAAAGCCTGTGCCCAAGTTGGTATAGATTCTCAAGTGATTACACTACCAGA
GCATACTACAGAATCAGAACTTTTGGAGCTGATCGATCAGCTAAATAATGACTCTAGTGTTCATGCGATT
TTAGTGCAGCTACCATTACCAGCACATATCAACAAAAACAATGTAATATATAGTATAAAACCAGAAAAAG
ATGTCGATGGTTTTCATCCTACAAATGTTGGTAGACTACAACTTAGAGATAAAAAATGCTTAGAATCTTG
TACACCTAAAGGTATCATGACTATGCTAAGAGAGTATGGTATAAAAACAGAGGGGGCCTATGCAGTGGTT
GTCGGCGCAAGTAATGTTGTTGGTAAACCAGTATCACAATTGCTGCTAAATGCTAAAGCTACAGTGACGA
CTTGTCATAGATTCACAACTGATCTTAAATCACATACTACAAAAGCAGATATCCTAATTGTTGCTGTTGG
TAAGCCTAACTTTATCACAGCTGATATGGTCAAAGAGGGTGCTGTAGTTATTGATGTTGGTATTAATCAT
GTTGATGGTAAGATAGTTGGTGATGTTGATTTTGCTGCTGTAAAAGATAAGGTCGCAGCAATTACCCCAG
TACCTGGAGGGGTTGGACCAATGACAATTACTGAACTGTTATATAATACTTTTCAGTGTGCTCAGGAGTT
GAATAGGTA
Protein Sequence 
>gi|56707993|ref|YP_169889.1| bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase [Francisella tularensis subsp. tularensis SCHU S4] MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: folD mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0190H, under H: Coenzyme transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].