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fadD1

Victor ID 678
Gene Name fadD1
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191870
NCBI Protein GI 56708316
Locus Tag FTT1254
Protein Accession YP_170212.1
Other Database IDs UniProtKB-ID: Q5NFI0_FRATT
UniRef100: UniRef100_Q14GY2
UniRef90: UniRef90_Q14GY2
UniRef50: UniRef50_B0TYG0
UniParc: UPI000049C4CF
EMBL: AJ749949
EMBL-CDS: CAG45887.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG547964
OMA: DFEKINK
ProtClustDB: CLSK934923
Taxonomy ID 177416
Gene Starting Position 1274815
Gene Ending Position 1276506
Gene Strand (Orientation) +
Protein Name Acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)
DNA Sequence 
>gi|56707187:1274815-1276506 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGAGTACATTTTCCAATAAAACATGGATAGCTAATTATCCTGATTATACTCCTGAGAATATTACGGAA
AACCACGCTACAATTTTAGATCTATATGAAAAAACAATTATACAATTTCCTTACAGAGAGGCTGTATCAT
GTCACGATGTAAATCTAACTTTTATTGAACTTGACAAGCTTGCTACTAAAATGGCTAGTTTTCTACAAAA
CAACCTTGGAATCAACAAGGGAGATAGAGTCGCAATTGTACTACCTAACTGCTTACAATTTACTGTTAGC
TTATTTGCATGTGTTAAGATTGGTGCTGTATTTGTCAACACCAACCCTCTTTATACTGCAGATGAGATTG
AAGCAATATTTAATAATTGTAATGTCAAAGCTGCGATTGTAATGGATATGTTTGCCCATCATATACAAAA
AGCTCGTGTAAACATAGACTCTTTAGAGAATGTAATAGTTACAAATATTGCTGATTTATACCCATTTCCT
AAAAAACAGATTATTGGTTTTGTCTCTAAATATTTAATTGAAAATAAACCAAAGTATACAAAAAGTAATT
TTATTGCGTTTAGTAAAGTCATTAAAGCTGACATAAGTTTATATAAAAAACCTGTTTTAACAAAACAAGA
TATACTATGTTTGCAATACTCAAGTGGAACAACTGGAAGACCTAAAGGAGCAATACTAACGCATGATAAT
CTTGCTTCAAATATTCAGCAAGTTTGGGCATGGATCAAACATGACATGGATATGTCTGATCAAGTAATTA
TAACTGCACTACCTCTTTACCATATATTCTCACTAAGTGCTAATTTACTTTGCTTCTTTTTTGCTGGTGC
AAAAAATGTCTTAATTCCCAATGCTAGAGATATAAAAAACCTCATTAAGACTATGTCAAAAAATGAATTC
ACTATTTTTAATGGTCTTAACACCCTCTATATGGCAATGCTTGAGCATCCTAATTTTGAGAAAATTAACA
AAACAAGATATCTATATTCTTTAAGCGGGGGCATGCCAATTTCACGTAAAATATATTTAGAGTGGTTAGA
TAGAACTGGTGTAGAACTAAAAGAGGGTTATGGTATGACTGAAATGTCTCCGGCAATCGCTCTAAATAAA
TTCAACGAGTCTGAGGATGATTATTTTGGTACTTGTGGCTACCCTATTCCGAGCACAGAGCTCAGTATTC
GTGATATCCATACTCACCAAGAAATAACTGAGTGTTTCAAAGAAGGTGAAATCTGGCTTAAAGGTCCACA
AAGATGTCAAGGTTTCTGGAATGATAAAGAGAATAATGAACTTCACTTTACTGCAGATGGTTGGCTAAAA
ACTGGAGATATTGGCTATATAGACAAAAAAGGTCGTCTAACTATATCCGATAGAATTAAAAATATGATAA
TTGTCTCCGGTTTTAATGTTTATCCGAGAGAAATTGAGTTATGCATACTTAAGTTAGACTATGTAAGAGA
GGTAGCTGTCACTGGAATTAAGTCAAAAACATCTGGTGAAAGACCTATAGCTTTTATCTCATTGGAAAAA
GGCTCAAATGCAACTGAGGAAGATATTATCAAACATTGCAAAGATAAATTAGCAAGCTATAAAGTCCCTA
GATCATGTATATTTGTAGAAACTCTACCAAAAAATAATACTAGTAAAATAGATATTAAGAAACTAAAAAA
TCAGTTCTTATA
Protein Sequence 
>gi|56708316|ref|YP_170212.1| acyl-CoA synthetase [Francisella tularensis subsp. tularensis SCHU S4] MSTFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKLATKMASFLQNNLGINKGDRVAIVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIFNNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLYPFPKKQIIGFVSKYLIENKPKYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQVWAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSKNEFTIFNGLNTLYMAMLEHPNFEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGYGMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIHTHQEITECFKEGEIWLKGPQRCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIELCILKLDYVREVAVTGIKSKTSGERPIAFISLEKGSNATEEDIIKHCKDKLASYKVPRSCIFVETLPKNNTSKIDIKKLKNQFL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fadD1 mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].