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purE

Victor ID 652
Gene Name purE
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191675
NCBI Protein GI 56707997
Locus Tag FTT0896
Protein Accession YP_169893.1
Other Database IDs UniProtKB-ID: Q5NGE9_FRATT
UniRef100: UniRef100_Q14HV1
UniRef90: UniRef90_A7NA95
UniRef50: UniRef50_Q5E1R4
UniParc: UPI0000450046
EMBL: AJ749949
EMBL-CDS: CAG45529.1
RefSeq_NT: NC_006570.2
PDB: 3OOW
GenomeReviews: AJ749949_GR
HOGENOM: HBG301965
OMA: QSDWATM
ProtClustDB: CLSK934740
Taxonomy ID 177416
Gene Starting Position 905380
Gene Ending Position 905871
Gene Strand (Orientation) +
Protein Name phosphoribosylaminoimidazole carboxylase,catalyic subunit
DNA Sequence 
>gi|56707187:905380-905871 Francisella tularensis subsp. tularensis Schu 4, complete genome
GATGAGTGTACAAGTTGGTGTAATAATGGGCTCTAAATCTGATTGGAGTACAATGAAAGAATGTTGTGAT
ATCTTGGATAATTTAGGTATTGGTTATGAATGTGAAGTAGTGTCTGCTCATCGAACTCCAGATAAGATGT
TTGACTATGCCGAAACTGCTAAAGAAAGAGGCCTTAAGGTTATAATAGCAGGAGCTGGCGGTGCTGCACA
TTTACCTGGAATGGTTGCGGCAAAAACTACTTTACCAGTATTAGGTGTACCAGTTAAATCAAGTACACTT
AATGGCCAAGATAGTTTATTATCAATAGTACAGATGCCAGCGGGTATTCCAGTAGCTACTTTTGCAATTG
GTATGGCAGGAGCAAAAAACGCGGCGCTTTTTGCTGCAAGTATCTTGCAACATACAGATATAAATATTGC
AAAAGCACTAGCTGAGTTTAGAGCTGAGCAAACACGATTTGTTTTGGAAAATCCTGATCCTAGGGAGCAC
TA
Protein Sequence 
>gi|56707997|ref|YP_169893.1| phosphoribosylaminoimidazole carboxylase catalyic subunit [Francisella tularensis subsp. tularensis SCHU S4] MSVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAETAKERGLKVIIAGAGGAAHLPGMVAAKTTLPVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAGAKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDPREH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purE mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0041F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].