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purF

Victor ID 651
Gene Name purF
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191669
NCBI Protein GI 56708727
Locus Tag FTT1721c
Protein Accession YP_170623.1
Other Database IDs UniProtKB-ID: Q5NEB9_FRATT
UniRef100: UniRef100_B2SEA0
UniRef90: UniRef90_B2SEA0
UniRef50: UniRef50_B2SEA0
UniParc: UPI000049C5E8
EMBL: AJ749949
EMBL-CDS: CAG46354.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG392416
OMA: GIPFELG
ProtClustDB: PRK09246
Taxonomy ID 177416
Gene Starting Position 1805988
Gene Ending Position 1807478
Gene Strand (Orientation) -
Protein Name amidophosphoribosyltransferase
DNA Sequence 
>gi|56707187:1805988-1807478 Francisella tularensis subsp. tularensis Schu 4, complete genome
ATTAGTTATCAAACCCTTTGTATTTTTTTTCTAATTCTTTTAACTCTTTACGATGTTTCTCTAGCGCATC
TAGATAAGCATCATCGACATCACCTGTAATGTAATTACCAGAGAAAACACTATCCTCAAACTCTCTAATT
TTAGGGTTTTGCTTTTGAATAATCTCTTTTAGATCCTCTAATGGTAAATATATTAGTCCATCTACTCCAA
TCCACTGGCGAATCTCTTCTATAGTCTTTCCATGAGCAATTAAATCCGACTTAACCGGCATATCAATACC
ATAAACATTTGGATAACGAACGGCTGGAGATACTGAAGCAAGATAAACAGATTTAGCACCTAAATCTCTA
ATCATCTCAATAATACGCTTTGATGTTGTACCTCGGACAATAGAATCATCAACAAGTAGAACATTTTTAT
CCCTAAATTCTGCTGGAATAGGGTTTAGTTTTCTTCTGACAAAATTCTTTCTATCAACATTCTCTGGCAT
GATAAAAGTTCTACCAACATAGCGATTCTTAACAAAACCTTCACGGTACTCAACACCTAATGCTGTTGCA
ATCTCTTGAGCAGAGGCTCTACCTGTCTCAGGTACAGGGATAACGATATCGATATCCTTATCCTTCCACG
CTTCTTTGATTCTCTTACTTAGGATTTTACCCGCATCTACTCGCGCTTGATAAACACTCACACCATTCAT
AATACTATCAGGACGTGCAAAGTATACATACTCAAATAGGCATGGTGCCAAAACTGGATTCTTTGCACAG
ATTTTAGAGTGAACTTTTCTATCCTCTGTAATTATTATCACCTCACCAGGCTCAACATCACGTAATACTT
TAAATCCGGAAATATCTAAAGCAACACTTTCACTAGCGACCATGTAAGCTTTTTCACCATCATCGTACTC
TTTAAAACCAAGCACAAGTGGACGAATACCATAAGGATCTCTAAAAGCAATTAAACCAAAATTTGCTATC
ATCGCAGTACATGCATAACCACCTTTGACATGCTCAAAAACAAATTTACATGCTTTATAAACAGCCTCAG
AAGTCGCAGATCCTTTTGATTTATTCATCCCACAAGCAAAGAAATTAAGCAATAATTCGGAATCTGAACT
TGTATTAAGATGGCGTCTTTCAATATCATGGAGCATTTGTGCAAGCTCTGGCACATTAGTCAGATTGCCA
TTATGAACGAAAACTATACCATGGGGATTATTTACATAAAAAGGTTGGCTATCAGCTGCACCCAAGCTAC
CTGCAGTAGGATATCTAACATGACCGATACCCATATTACCTTTTGACTTCTCTAGTTTTTCATCTGTAAA
TACATCACTTACTAGACCTGTATTTTTACGGATAAAAAAGTGCCCATGATCCATAGTTGCAATCCCTGCA
GCATCTTGACCCCTATGCTGCAAAAGACTTAAACCATAAAATAATGCATAACTAACCTGATCTGGTCCAG
CGACTCCAATTACTCCACACA
Protein Sequence 
>gi|56708727|ref|YP_170623.1| amidophosphoribosyltransferase [Francisella tularensis subsp. tularensis SCHU S4] MCGVIGVAGPDQVSYALFYGLSLLQHRGQDAAGIATMDHGHFFIRKNTGLVSDVFTDEKLEKSKGNMGIGHVRYPTAGSLGAADSQPFYVNNPHGIVFVHNGNLTNVPELAQMLHDIERRHLNTSSDSELLLNFFACGMNKSKGSATSEAVYKACKFVFEHVKGGYACTAMIANFGLIAFRDPYGIRPLVLGFKEYDDGEKAYMVASESVALDISGFKVLRDVEPGEVIIITEDRKVHSKICAKNPVLAPCLFEYVYFARPDSIMNGVSVYQARVDAGKILSKRIKEAWKDKDIDIVIPVPETGRASAQEIATALGVEYREGFVKNRYVGRTFIMPENVDRKNFVRRKLNPIPAEFRDKNVLLVDDSIVRGTTSKRIIEMIRDLGAKSVYLASVSPAVRYPNVYGIDMPVKSDLIAHGKTIEEIRQWIGVDGLIYLPLEDLKEIIQKQNPKIREFEDSVFSGNYITGDVDDAYLDALEKHRKELKELEKKYKGFDN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purF mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0034F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].