Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

purH

Victor ID 650
Gene Name purH
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191667
NCBI Protein GI 56707367
Locus Tag FTT0203c
Protein Accession YP_169263.1
Other Database IDs UniProtKB-ID: Q5NI79_FRATT
UniRef100: UniRef100_A0Q4C2
UniRef90: UniRef90_A7NEW0
UniRef50: UniRef50_Q3JC90
UniParc: UPI000049C214
EMBL: AJ749949
EMBL-CDS: CAG44836.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG498048
OMA: VVKHVKS
ProtClustDB: PRK00881
Taxonomy ID 177416
Gene Starting Position 220940
Gene Ending Position 222487
Gene Strand (Orientation) -
Protein Name bifunctional purine biosynthesis protein
DNA Sequence 
>gi|56707187:220940-222487 Francisella tularensis subsp. tularensis Schu 4, complete genome
TTTAGTGTCTAAAATGTCTCATATTTGTGAAGACCATAGTGATACCAGCTTTGTTAGCAGCATCAATAAC
TTCTTGATCATTTTTTGAACCGCCTGGTTGAATTACCGCTGTTGCTCCAGCTTTGATACATTCTTCTAAA
CCGTCAGCAAAAGGGAAGAAAGCATCAGATGCGACAGCAGAACCTTTAGCACCTTGATGAGCTTGGGCTT
TTTCAGCACCAATACGTGCAGAATCAACTCGACTCATCTGTCCAGCACCAATTCCTACTGTTTGGGTATC
TCTAGCATAGACAATTGCATTTGATTTGACGTATTTAACAGCTTTCCAGGCAAACATTAAATCAGCCCAC
TCTTTGTCAGTTGGCGCTCTATCTGTAACAACTTTACAGTCATTAATGTCAACGCCACCGTTATCATAAG
ATTGAGATAGTATTCCACCATGAATATTTTTACTTATCATACGTGATGATTTTGTATCAAAAACTTTACC
AGTTTCTAATACGCGTAAGTTTTTCTTAGCTGCTAAAATATCTAGAGCTTCTTGAGTATAGCTTGGTGCA
ATTATTACTTCTAAAAACATTTTACCTAGAGATTCAGCAAACTCTTTGTCAACTTCACAGTTAAACGCAA
CAATTCCACCAAAAGCTGAAATTGGATCACAAGCTAGAGCTTTTGTCCAAGCTTCAAAAGCATTTTTACC
AGAAGCGATACCACAAGGATTAGCATGTTTGATAATTGCACAAGAGGGTTCTGAATACTCACAAACCATC
TCAAAAGCACCATCGGCATCATTTAGGTTATTATACGATAATTCTTTGCCTTGTAATTGTCTTGCATTTG
TAATGCTTACACAGTCAGCATCTGTAGAGTATACAGCTGCTTTTTGATGAGGATTTTCGCCATATCTTAA
AACCTGTTTTAGAGTTCCTACAGAAAAAAGTTTCTCAGGATACTCTTCATCTAGCTCTTTACTAAACCAG
TTTGCAATATGACTATCATATTCGGCAGTATGTGCAAACGCTTCTTTAGCAAATTCACGACGTGTTGCTA
GAGTAGTTTTGCCATCATTCTCAGCCATCTCTTTGATAACTAGATCATATTGACTAGGGTTGGTCACTAT
AGTTGTGTGTTTATGATTTTTTGCACATGATCTCACCATAGAAGGTCCGCCGATATCTATGTTTTCGATA
CAGGTATCAAAATCAGCACCGGATTTAACTGTATTGACAAAAGGGTATAAGTTAACGACTACCATATCTA
TTTGTCCAATATGATTTTTTAGCATCGCATCGAGATGCTCAGGATTATCTCTATCGGCTAAGATACCACC
ATGAATTAGTGGATGAAGTGTTTTTACACGACCATTCATAATTTCTGGAAATTGTGTATGCTCTGAAACA
TCTATTACGTTTATTCCAGCATCTTTAAGGGTTTTTGAAGTTCCACCTGTTGAAAGTATTTCGATGTTAT
ACTTACTTAATTCTTTGGCAAATTCAATGATACCTGTTTTATCAGATACAGATATTAGTACCCTTTTTAT
TTTTGACA
Protein Sequence 
>gi|56707367|ref|YP_169263.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Francisella tularensis subsp. tularensis SCHU S4] MSKIKRVLISVSDKTGIIEFAKELSKYNIEILSTGGTSKTLKDAGINVIDVSEHTQFPEIMNGRVKTLHPLIHGGILADRDNPEHLDAMLKNHIGQIDMVVVNLYPFVNTVKSGADFDTCIENIDIGGPSMVRSCAKNHKHTTIVTNPSQYDLVIKEMAENDGKTTLATRREFAKEAFAHTAEYDSHIANWFSKELDEEYPEKLFSVGTLKQVLRYGENPHQKAAVYSTDADCVSITNARQLQGKELSYNNLNDADGAFEMVCEYSEPSCAIIKHANPCGIASGKNAFEAWTKALACDPISAFGGIVAFNCEVDKEFAESLGKMFLEVIIAPSYTQEALDILAAKKNLRVLETGKVFDTKSSRMISKNIHGGILSQSYDNGGVDINDCKVVTDRAPTDKEWADLMFAWKAVKYVKSNAIVYARDTQTVGIGAGQMSRVDSARIGAEKAQAHQGAKGSAVASDAFFPFADGLEECIKAGATAVIQPGGSKNDQEVIDAANKAGITMVFTNMRHFRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purH mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0138F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].