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purL

Victor ID 649
Gene Name purL
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191665
NCBI Protein GI 56708726
Locus Tag FTT1720c
Protein Accession YP_170622.1
Other Database IDs UniProtKB-ID: Q5NEC0_FRATT
UniRef100: UniRef100_Q14FS3
UniRef90: UniRef90_A0Q8J1
UniRef50: UniRef50_Q1R8H7
UniParc: UPI000049C5E7
EMBL: AJ749949
EMBL-CDS: CAG46353.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
Taxonomy ID 177416
Gene Starting Position 1802116
Gene Ending Position 1805988
Gene Strand (Orientation) -
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|56707187:1802116-1805988 Francisella tularensis subsp. tularensis Schu 4, complete genome
ATCATCCAACCCACTTCCTAGCATTTCTAAACATTCTCATCCATACAGAATACTCATCATATTCCGCTGG
GATATGCGAGTTTGTAATAGCTCTATACACACGCTCTGGATGTGGCATCATCGCAAGGACACGACCATCT
AAAGCTGTCACAGCTGTTAGACCATTTACTGCACCATTTGGATTGTATGGATACATCTCAGTTGCTTGAC
CTTGCCCATCAATATATTTAAGAGCTACTTGAGCACTTGCTAGCATAGCTTGTTGCTGGTTGTCATTTTC
AAATAATGGGCGACCCTCACCATGAGCTACAGCAATTGGTGCTTTTGTGCATGCCATATCAGCGAACCAA
ATAGAGTCAGACTCTTGAATCTCAACCATAGACACTCTAGCCTCAAACTGCTCTGATTTATTCTTGATAA
ATATCGGCCAGTTTTCAGCGCCTTTGATTAGTGATTTAAGCTGTGCAAGCATTTGGCAACCATTACATAC
ACCTAATGCTAAAGTATCATCGCGCCCAAAGAATCTACTAAACTCATCTCTTAGCTTCTCAGTAAAGAGG
ATATTCTTCGCCCAGCCACCGCCAGCGCCCAAGACATCACCATATGAGAAACCACCACAAGCTACCAATA
CTTTGAAATCTGCCAAAGTTACACGCCCAGCATGTAAATCTGACATATGGACATCATGAGCCTCAAAGCC
AGCTGTAGTAAATGCTGCTGCCATCTCAACTTGACCATTGACACCTTGCTCTCTTAAGATTGTAACTTTT
GGCTTTTCAACATTGACAAACTTAGCTGTGATATCCTCTTCAAGATCAAATGTAGCCTCAACATGGATAC
CTTTATCATTAGTATTTAAGATACTATCGAACTCTTGTTTAGCGCATTCGCTATTATCACGAATTGATTG
GATTTGATAAGAAGTCTCAGCCCACCATCTTTGTAAATTTACACGTGTGTTTGAGTATATTTTTTCACCA
TTTGCAAAGATATTTAGCTCATCACTAGAGTTTAGCTTAGCTATTGCACACAGGTGAATTTGAGTATCTT
TAAACATCTCTTCAACTAGTGATACATCGCTATTTCGAACTTGGATAACAACTCCAACTTCCTCGGCAAA
GAGTTTCGCTAACACATCTTGAGTTTGTAGTTTAACATCTAAACCTTTACGCCCTGCAAATGACATTTCT
GCTAAAGTTGCAAACACACCACCATCAGATACATCATGATATGCTAAAATTTTATTTTCAGCTTTTAGTT
TAGTGATATTTTCAAATAGCACTTTTACCTTACTTGCTTCAATATCTGGCGCAACATTACCAACTTGATT
ATAAGCTTGAGCTAAACATGAAGCCCCAAGTCTACCGGCACCATTTGATAGATCAATGTGTAATAAAGTT
GTATCATTATCATCAACTAAAACTGGTGTAAGAGTCTTACGCGCATTTGTCACAGGCGAGAAACCTGAGA
TCACTAACGATAATGGCGATGTCACTGATTTAGCTTGACCGTTATCTGACCACTTAGTTTTCATTGACAT
TGAATCTTTACCAACTGGTATTGCAATACCCAACTCTGGTGCAAATTCCATACCAACAGCTCTTACAGTT
TCATATAATTTTTGGTTTTCGTCACCTTGATTTGCAGCAACCATCCAGTTAGCAGAGAGGCGAATGTCAC
TCAACTTTTCAATATCCGCAGCTAATAAGTTTGTTACAGTCTCAGCAATCGCTAATCTACCAGAAGCCGC
AGCATTAATAGCAGCAACAGGAGTTCTCTCGCCCATTGCCATAGCCTCACCAGCTTGACTATCTACAGTA
GCAGTTGTCACAGCACAATCAGCTACAGGCACTTGCCATGGACCAACCATTTGATCTCGTGCAACCATAC
CTGTAATACTTCTATCACCAATTGTGATTAGGAAAGATTTAGAAGCTACAGCTGGTACTTTTAGCACTCT
CTCAATCGCTTCATCAAGCTTAATAGCACTTGTATCAAAAGCTTGTTGCTCAACTTTGACAGTTTTTACA
TCAATATGCATTTGTGGTGTATTACCAAATAATAATCCCATTGGTAAATCAACCGGCTTATTATCAAAAT
ACTCATCATTTAGAGTGATATGCTTTTCAGAAATCGCCTCACCAACTACTGCAAATGGACATCTTTCTCT
ATTACATAACTGCTCAAAAAGCTCTAGTGACTCAGGGTCAACTGATAATACATATCTTTCTTGTGACTCA
TTTGACCATATTTCCAGTGGAGAAAGCCCCTCTTCACCGACATTTACTTTTCTAAGCTCAAAATAACCGC
CTACGCCACCATCTTTGACAAGCTCTGGGAAAGCATTTGAAATACCGCCAGCACCAACATCATGGATAAA
TGTGATTGGGTTATTCTCGCCCATTTGCCAACATCTGTCGATTACCTCTTGGCAACGGCGCTCCATTTCG
GCATTATCACGCTGAACTGATGCAAAATCTAGCTCTGAGTTAGTATCAGAAGATACAACAGATGACGCAG
CACCACCACCAAGACCAATACGCATCGCAGGCCCACCAAGACAGATTAGCTTAGCACCAACTTTGATAAC
GCCTTTCTCAACATGCATTCTTTTGATATTACCCATACCACCAGCAATCATAATTGGCTTATGGTATCCA
AACATCTCTTTGCCAGCAGATGTATTGACCTCTTGCTCATAGGTACGGAAATAACCATTTAAATTTGGAC
GACCAAATTCATTTGAGTAATGAGCACCACCAATAGGCGCCTCTAGCATTATTTGTAAAGGTGTTACAAT
ATGGTTAGGCTTACCATATTTACTAGTCTCCCAAGCCTGTTCAAAACCTGGAATATTTAGATTTGAAACT
GTAAAACCAGTCAAGCCAGCTTTTGGTTTTGCTCCAAGACCTGTTGCACCTTCATCACGAATCTCACCAC
CAACACCAGTAGCTGAGCCACTAAATGGTGCTATAGCAGTTGGGTGATTATGAGTCTCAACTTTCATCAA
GATATCAACTTCTTCTTGATTGAAACTATAGACACCAGTTTGCGTATTTGGATAGAATCTTTGAGCCGTT
GCACCCTCTATCACAGCAGCATTATCCTTATATGCTGATAGCACACCTTGTGGAGATTTCTCAGTAGTAT
TTCTAATCATCTTAAACAATGATTTATCTTGCTCCTGACCATCTATAGTCCATTTAGCATTAAAAATCTT
ATGTCTACAATGCTCCGAATTTGCTTGGGCAAACATATATAACTCTGTATCTGTAGGATTTCTACCAAGC
TTTGTATATTCATCTGCTAGATATTCAATCTCTTGCTCACTTAGAGCTAAGCCAAGTTTTCTATCAGCTT
CTTTGATAGCTTGAGCACCTTTTTCTAAAACATTAACAAATTCAAGTTCTTTTGGTGCTGTTACACTAAA
GAGTCTATATAAATCATCTTTGCAACTAAACACTTCCTCAACCATACGGTCATGAACGATATCTTGGATT
TGTTTTAGCTCACTAGCAGAAACTTGTCCCTCAACACCGAATAAAATAGCTCTTTCTATCCTTTTAACAG
CTTTGATACCAGTATTTTTGATAATATCGGTAGCTTTAGAAGACCAAGGCGATATAGTGCCAACTCTTGG
AGCTATGATAAAAGTATGACCCATAGGCTGAGCTATGCCATACTCTCTATTGTAGTTAAGTAGAGATTTA
ACTATTCTTTCTTGCTCACTATTTAACTCTGATTCAAGCTCTGTAACATGGATATACTGTGCAGATACTG
ATTCAACTTTATTGGATATTTTTTTAGCAGCTGCTAAAATTTTTTCTCGCTTAAAAGGAGACAGTGCACT
TAAACCTTCAAAAATCGTAATCA
Protein Sequence 
>gi|56708726|ref|YP_170622.1| phosphoribosylformylglycinamidine synthase [Francisella tularensis subsp. tularensis SCHU S4] MITIFEGLSALSPFKREKILAAAKKISNKVESVSAQYIHVTELESELNSEQERIVKSLLNYNREYGIAQPMGHTFIIAPRVGTISPWSSKATDIIKNTGIKAVKRIERAILFGVEGQVSASELKQIQDIVHDRMVEEVFSCKDDLYRLFSVTAPKELEFVNVLEKGAQAIKEADRKLGLALSEQEIEYLADEYTKLGRNPTDTELYMFAQANSEHCRHKIFNAKWTIDGQEQDKSLFKMIRNTTEKSPQGVLSAYKDNAAVIEGATAQRFYPNTQTGVYSFNQEEVDILMKVETHNHPTAIAPFSGSATGVGGEIRDEGATGLGAKPKAGLTGFTVSNLNIPGFEQAWETSKYGKPNHIVTPLQIMLEAPIGGAHYSNEFGRPNLNGYFRTYEQEVNTSAGKEMFGYHKPIMIAGGMGNIKRMHVEKGVIKVGAKLICLGGPAMRIGLGGGAASSVVSSDTNSELDFASVQRDNAEMERRCQEVIDRCWQMGENNPITFIHDVGAGGISNAFPELVKDGGVGGYFELRKVNVGEEGLSPLEIWSNESQERYVLSVDPESLELFEQLCNRERCPFAVVGEAISEKHITLNDEYFDNKPVDLPMGLLFGNTPQMHIDVKTVKVEQQAFDTSAIKLDEAIERVLKVPAVASKSFLITIGDRSITGMVARDQMVGPWQVPVADCAVTTATVDSQAGEAMAMGERTPVAAINAAASGRLAIAETVTNLLAADIEKLSDIRLSANWMVAANQGDENQKLYETVRAVGMEFAPELGIAIPVGKDSMSMKTKWSDNGQAKSVTSPLSLVISGFSPVTNARKTLTPVLVDDNDTTLLHIDLSNGAGRLGASCLAQAYNQVGNVAPDIEASKVKVLFENITKLKAENKILAYHDVSDGGVFATLAEMSFAGRKGLDVKLQTQDVLAKLFAEEVGVVIQVRNSDVSLVEEMFKDTQIHLCAIAKLNSSDELNIFANGEKIYSNTRVNLQRWWAETSYQIQSIRDNSECAKQEFDSILNTNDKGIHVEATFDLEEDITAKFVNVEKPKVTILREQGVNGQVEMAAAFTTAGFEAHDVHMSDLHAGRVTLADFKVLVACGGFSYGDVLGAGGGWAKNILFTEKLRDEFSRFFGRDDTLALGVCNGCQMLAQLKSLIKGAENWPIFIKNKSEQFEARVSMVEIQESDSIWFADMACTKAPIAVAHGEGRPLFENDNQQQAMLASAQVALKYIDGQGQATEMYPYNPNGAVNGLTAVTALDGRVLAMMPHPERVYRAITNSHIPAEYDEYSVWMRMFRNARKWVG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].