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purM

Victor ID 648
Gene Name purM
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191664
NCBI Protein GI 56707994
Locus Tag FTT0893
Protein Accession YP_169890.1
Other Database IDs UniProtKB-ID: Q5NGF2_FRATT
UniRef100: UniRef100_A0Q507
UniRef90: UniRef90_A7NA92
UniRef50: UniRef50_Q5ZUW5
UniParc: UPI000049C3DE
EMBL: AJ749949
EMBL-CDS: CAG45526.1
RefSeq_NT: NC_006570.2
PDB: 3M84
GenomeReviews: AJ749949_GR
HOGENOM: HBG531222
OMA: VHGLAHI
ProtClustDB: PRK05385
Taxonomy ID 177416
Gene Starting Position 901329
Gene Ending Position 902372
Gene Strand (Orientation) +
Protein Name phosphoribosylaminoimidazole synthetase
DNA Sequence 
>gi|56707187:901329-902372 Francisella tularensis subsp. tularensis Schu 4, complete genome
AATGGCAGGCTTAAAATATGAAGATGCTGGCGTAAATATCGAAGCTGGTAATCAAGCTGTAGAAAGAATG
AAGCAGCATGTCAAAAAAACTTTTACCCAAGATGTTTTGACAGGTTTGGGTAGCTTTGGTTCTTTATACT
CACTAAAAAATATTATAAATAATTATGATGATCCTGTCTTAGTACAGTCGATTGATGGTGTTGGTACAAA
GACAAAAGTCGCGGTAATGTGTGGTAAGTTTGAAAACCTTGGTTATGATCTTTTCTCAGCTGCGACAAAT
GATATTGTTGTAATGGGTGCCAAGCCAATTACGTTTCTAGATTATGTCGCGCATGATAAGCTTGACCCTG
CAATTATGGAAGAGCTCGTCAAAGGGATGTCAAAAGCTTGTGCTGAGTGTGGGGTTTCGCTGGTAGGTGG
CGAGACTGCGGAAATGCCTGGAGTATATCAAGCTGGTGAGATTGACATGGTTGGAGTTATCACTGGTATC
GTTGATAGAAAAAGAATTATCAATGGTGAGAATATCAAAGAGGGTGATATTGTCTTTGGGCTTAGTTCAT
CAGGATTACATACAAATGGCTACTCTTTTGCACGTAAACTATTTTTTGATGTAGCAGGCAACAAACATAC
TGATACTTATCCAGAGTTAGAGGGTAAAACTATCGGTGATGTGCTACTTGAACCACATATCAACTATACT
AATATCATCCATGATTTCTTAGATAATGGTGTTGATATCAAAGGTATGGCACATATCACAGGTGGCGGGT
TTATCGAGAATATTCCACGCGTATTACCACAAGGTTTAGGTGCCCAAATTGACAAAGATAGTTTTGCAAC
TCCAGCTATTTTTAAGCTAATGCAGAGAATCGGCGATATAAGCGAGTTTGAAATGTATCGCTCATTTAAT
ATGGGTATTGGTATGACGATAATTGCTAGCCAAGATCAATTTGACAAGATGCAAGAATTAGCTAAAAAAC
ATACTAATACAAAACTATATCAAATTGGTAAAATCACAAATTCAGGAAAGGTAGAAATTATCTA
Protein Sequence 
>gi|56707994|ref|YP_169890.1| phosphoribosylaminoimidazole synthetase [Francisella tularensis subsp. tularensis SCHU S4] MAGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVLVQSIDGVGTKTKVAVMCGKFENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIMEELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVITGIVDRKRIINGENIKEGDIVFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFLDNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYRSFNMGIGMTIIASQDQFDKMQELAKKHTNTKLYQIGKITNSGKVEII
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purM mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0150F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].