Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

putA

Victor ID 646
Gene Name putA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191660
NCBI Protein GI 56708221
Locus Tag FTT1150c
Protein Accession YP_170117.1
Other Database IDs UniProtKB-ID: Q5NFS5_FRATT
UniRef100: UniRef100_Q14H77
UniRef90: UniRef90_Q0BMF0
UniRef50: UniRef50_Q0BMF0
UniParc: UPI000049C48D
EMBL: AJ749949
EMBL-CDS: CAG45783.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG288861
OMA: QPFLEFA
ProtClustDB: PRK11905
Taxonomy ID 177416
Gene Starting Position 1161753
Gene Ending Position 1165826
Gene Strand (Orientation) -
Protein Name bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase
DNA Sequence 
>gi|56707187:1161753-1165826 Francisella tularensis subsp. tularensis Schu 4, complete genome
TTTATTCTTCTAGGCTCATTAAAGAAGCATTACCACCAGAGGCAGTTGTATCAACACTTACGGTTTTTTC
AACTACAAACCTGCGTAAATACAATGGTGAAGCTGTTTCTATTGCTAAGCTTGTACATTTGCCATTTTTA
GCAACACTCTCAGCAACAAAAGGTATAATCGCACCTCTACGTAATACTAAAGCCTGATGAACCTGTTTAA
CCGCAGAAACACTACCAGAGAAGGCAACTAGTGCAACCTTACTATTAAATAATAAAGCTGATGTTATCTC
TTCATCATCTGACAACACTAGATGAAGTACTTTAGAGTCTATTCCCGCTTTTAACATTAATTTAACAATA
TTATAAGCAGTTAAATTACCGGTATATGCTGGCTTAGCTACTACAGTATTACCCGCTAGTAAAGCCGCAG
CAGTTTGACCAACAAATCTGATCAGTAAATCAGAACTTGAACACATACTTACTACAACACCTCGACCTTT
TAAGCTTAACTCATCAATCTCTCCTGTAGGTCCAGGTAAAAGTTGTGGATGAGCAAACTCTTTTTTAGCT
TGTAGGCAATAGTATGCCACCTGCTGAATAGTTTTATCTATTTGGATATGAGCATCCTCAACTGAAATAT
TTGACTCCACTACAAGAGATGAAGCTATCAAATGACGCTCTTTCTCTAATAGTTCTAAGAATTTCTCAAT
AGTGGCAGCTCTTTGTTCAGCATTAACATGATTCCATATCTCTACCTCTTTACTAGCAATTTCTATAGCA
TTATCTACAGTATTCACAGAAGCTACATATTTCTTACCAATCGTTTTACCATTTGCTGCTTTAAGATTAG
TATATTTATCTTTTTTAGCTTTCTCACCAGCAACAATATTTGTGATAGTATATTTATCTTTGATAAGCTT
GTTAGTCTGCTTTTCATCTTCAGCTATTTTTTCAGGATTGTAGATCTCTTCAACGGCACCTACTCCTGAT
AATTTTTCATTAGCTAAACGATGCATATAATAAGGGCCGCCAGCTTTAGGACCTGTTCCAGATTTGCCTT
GACCACCAAATGGTTGGACACCAACAACAGCACCAACAATATTCCTATTTACATAGATATTACCAGCTTT
AAGGTTATTTTTAACATAGTTCATCACTTCATTAATTCGACTATGCACACCGACTGTTAGACCATATCCT
GTAGCATTGATGTCGTTGATAAGCTTATCTAGTTGATTAGCCTTAAAGCGCAAGATATGTAAAATTGGAC
CAAACTGCTCTCTACCCAAATCAGATATTTTATCTATCTCAAAAGCAGTAGGCATCACAAATGTGCCCTT
TTGTGTATCTTGGTTAGGTTGAGCTTGATATATAAGCTTAAACTGGCTTTTTTTCTCTTCAATATACGCA
TTTAGATTATCAGCAGCCTCTTTATCGATCACAGGACCAACATCAGTATCAATATATTTAGAATCGCCTA
TTTTAAGTTCTTTCATTGCGCCAACTATCATCTTAATATAGTTATCAGCGATATCTTCTTGAAGACATAA
GATACGTAATGCTGAACAGCGTTGTCCCGCGCTATCAAAAGCTGAACGTATCACATCTGCGGTAACCTGC
TCAGGAAGCGATGATGAGTCAACAATCATAGCGTTTTGTCCACCTGTCTCAGCAATAAATAGTACTATTT
CACTAGATTTGTTTGCCAAAGTCTGATTTATAATAGCTGCAACCTCTGTAGAGCCTGTGAAAATCACACC
TTTACATACTGGGCTCTTAACCAGAGCACTACCAACTGTTGCACCATCACCAGGCGTAAATTGTAAAACA
TTTTTAGGTAAACCAGCTTTAAATAAAAGCTTAACAGCCTTATAAGCTATTATTGGCGTCTGCTCTGCTG
GTTTAGCAACTACTGTATTACCAGCTGCTAAAACAGCTGTTATCTGTCCTAAGAATATTGCCAATGGGAA
ATTCCAAGGGCTAATACATACCATAGCTCCGCGACCGGTAAACTCTATCTGCTTAAGATGATCTGATAAA
GCTGGCAATTCAATAGGACCATTAAATTCTTTTCTAGCTTGTGCAGCATAATAACGACAAAAATCTACAG
CCTCTCTAACCTCATCTATAGCATTAGCCAAGGTTTTACCAGCTTCAATCATTGCTATAGCAATAAATTT
ATTAGTATCTTGTTCTAAAAGATCAGCAAATTTCTCTAAAATATCTGCTCTTTTTGTTGCTGGTGTATTA
CTCCACTCTTCAAATGCACTTTGAGCATTTTTTAGTGCTCTTTTAGCAATTTTAGCATCAGCATTGATTA
CGCTACCGATGACTTCATTAGTATTTGGATTTATAACACTTTCAGTAATTGTTTTATCAAGATCAATACC
AGAAACTATCGGTTTTGCTTTATATGTATTTTTGTGCGTATATTTTTCTATTTGCTTATACATATCAGCC
AAAACAGCAAAATCATTAGTATTATGACCTTGTGAATTTAATCTTGGTGAGACTATATCTTTTGGATAAG
GAATATTAGGATGCTGACCACAACCATGATCGATAGCTTTTTTAACAGGATCTTCTATTAATTCTTCAAT
AGGTAGATTCTCGTCTACTATTCTATTTACGAATGAGCTATTAGCACCATTTTCTAGCAGTCTTCTTACT
AGATATGCTAAAAGATGCTTATGACCACCAACTGGTGCATATATTCTACATGGAATATCTTCATAGCCTT
CTTTACCAACGACATTGTCATATAGCGCATCGCCCATACCATGTAAACACTGAAATTCAAAATCTCTATT
ACCATTAGCTAACTCAAATACTACAGCGACAGTCTGAGCATTATGCGTTGCAAACTGAGGATAGATATAT
TGATGATTCTCAAAAAGCTGTTTAACACAAGCCTGATATGAGACGTCTGTGTGATATTTACGCGTAAATA
CTGGATAACCTGCTAAACCTTGCTCTTGCGCATGCTTAATTTCGGCATCCCAATACGCCCCCTTAACTAA
GCGGATCATAAATCTTCTATTAGTTTTCTTAGCAAGATTTGCTAAATAATCTAATACATAAGGAGCTCTT
TTTTGGTATGCCTGAACAACAATACCAATACCATTAAAACCTTCTAAAGATGGCTCATGAGCTAGTCTTT
CTACTAGTTCTAATGATATTTGTAATCTTTCTGTTTCTTCAGCATCGATATTCATCCCAACATTATAATC
TTTTGCTAATTGCGTAAGCTTAAGCAGTTTTGGATATAATTCTGTATGAACTCTTTGGTGCTTTGCAACC
TCATAGCGTGGATGTAAAGCAGATAATTTGATAGAAATTCCTGGATTTTTTTTGATTTCCGTATTTGTAG
CATACTTAGCTAACTCATGTATTGCATGAAGATACTGACTATAATAGTACTCAGCATCATCCATTGTCAT
TGCAGCTTCACCAAGCATATCATAAGAATAGCTATAGCCTCTGGCTACTTTGGCTTCTGATACCTTTAGA
GCTTCTTCGATAGTTTCACCAAGTACATATTGCTTACCAACAATTTTCATTGCTTGTTTCATTGCTTGAC
GAATTACTGGCTCACTAGTTTTTTTAAGAAAATTTTGAAAAACTTTTCTATAAGAACGATGCGGATCTTT
AAGAATTTTACCAGTTAACATCAAACTCCATGTCGCAGCATTAACAAATAGATGCTTTTCCATACCAACA
TGGTTTTTCCACGCAGCACTTGTAAGCTTATCTTTGATAAGCAGATCAATAGTATATTTATCAGGTACTC
TTAGCAGCGCTTCAGCTAAACACATCAGCACTATCCCTTCTTCTGATGATAAGTCATACTCGATCATAAA
CGCATCAATGCCAGACTTTTTGAGTCTATTCTTTCTGACTTTTTCTACTAAGCCATAAGCCCTTTCTCTA
ACTTGTGCCTTTTGAACGCTTGACATATGAGCTTTTTCAACAAGCTTTGTCATTGCTTCTTTTTCATCGA
TAAGCCAATATTTAGATATATTCATTATTTCTTTAGAAATAGGATATTCTCCTGAGTGATTTAGTAAGTC
ATTCATATAACACA
Protein Sequence 
>gi|56708221|ref|YP_170117.1| bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase [Francisella tularensis subsp. tularensis SCHU S4] MCYMNDLLNHSGEYPISKEIMNISKYWLIDEKEAMTKLVEKAHMSSVQKAQVRERAYGLVEKVRKNRLKKSGIDAFMIEYDLSSEEGIVLMCLAEALLRVPDKYTIDLLIKDKLTSAAWKNHVGMEKHLFVNAATWSLMLTGKILKDPHRSYRKVFQNFLKKTSEPVIRQAMKQAMKIVGKQYVLGETIEEALKVSEAKVARGYSYSYDMLGEAAMTMDDAEYYYSQYLHAIHELAKYATNTEIKKNPGISIKLSALHPRYEVAKHQRVHTELYPKLLKLTQLAKDYNVGMNIDAEETERLQISLELVERLAHEPSLEGFNGIGIVVQAYQKRAPYVLDYLANLAKKTNRRFMIRLVKGAYWDAEIKHAQEQGLAGYPVFTRKYHTDVSYQACVKQLFENHQYIYPQFATHNAQTVAVVFELANGNRDFEFQCLHGMGDALYDNVVGKEGYEDIPCRIYAPVGGHKHLLAYLVRRLLENGANSSFVNRIVDENLPIEELIEDPVKKAIDHGCGQHPNIPYPKDIVSPRLNSQGHNTNDFAVLADMYKQIEKYTHKNTYKAKPIVSGIDLDKTITESVINPNTNEVIGSVINADAKIAKRALKNAQSAFEEWSNTPATKRADILEKFADLLEQDTNKFIAIAMIEAGKTLANAIDEVREAVDFCRYYAAQARKEFNGPIELPALSDHLKQIEFTGRGAMVCISPWNFPLAIFLGQITAVLAAGNTVVAKPAEQTPIIAYKAVKLLFKAGLPKNVLQFTPGDGATVGSALVKSPVCKGVIFTGSTEVAAIINQTLANKSSEIVLFIAETGGQNAMIVDSSSLPEQVTADVIRSAFDSAGQRCSALRILCLQEDIADNYIKMIVGAMKELKIGDSKYIDTDVGPVIDKEAADNLNAYIEEKKSQFKLIYQAQPNQDTQKGTFVMPTAFEIDKISDLGREQFGPILHILRFKANQLDKLINDINATGYGLTVGVHSRINEVMNYVKNNLKAGNIYVNRNIVGAVVGVQPFGGQGKSGTGPKAGGPYYMHRLANEKLSGVGAVEEIYNPEKIAEDEKQTNKLIKDKYTITNIVAGEKAKKDKYTNLKAANGKTIGKKYVASVNTVDNAIEIASKEVEIWNHVNAEQRAATIEKFLELLEKERHLIASSLVVESNISVEDAHIQIDKTIQQVAYYCLQAKKEFAHPQLLPGPTGEIDELSLKGRGVVVSMCSSSDLLIRFVGQTAAALLAGNTVVAKPAYTGNLTAYNIVKLMLKAGIDSKVLHLVLSDDEEITSALLFNSKVALVAFSGSVSAVKQVHQALVLRRGAIIPFVAESVAKNGKCTSLAIETASPLYLRRFVVEKTVSVDTTASGGNASLMSLEE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: putA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG4230C, under C: Energy production and conversion
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].