Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

pyrB

Victor ID 645
Gene Name pyrB
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191656
NCBI Protein GI 56708676
Locus Tag FTT1665
Protein Accession YP_170572.1
Other Database IDs UniProtKB-ID: Q5NEH0_FRATT
UniRef100: UniRef100_A4J093
UniRef90: UniRef90_A0Q3W5
UniRef50: UniRef50_A0Q3W5
UniParc: UPI000044FFAB
EMBL: AJ749949
EMBL-CDS: CAG46298.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG579429
OMA: QSFYGVP
ProtClustDB: CLSK935129
Taxonomy ID 177416
Gene Starting Position 1733688
Gene Ending Position 1734608
Gene Strand (Orientation) +
Protein Name aspartate carbamoyltransferase
DNA Sequence 
>gi|56707187:1733688-1734608 Francisella tularensis subsp. tularensis Schu 4, complete genome
AATGCTATCATTTCAAAAGTTACTACGCGGTGATCAAATTACTAAAGATGATTTGTTTAAACTATTTCAT
CAAGCTGATATTTATAAAAATAAACTAGCTAATTCAGAGCCTATCAAAGATTTAGAAGGCAAAATATTAG
CATCTCTTTTCTTTGAACCAAGCACTAGAACTAGATTCTCTTTTGAATCTGCTATGAATAGACTTGGTGG
TAAAGTAATATCACTAGAAAATGGCTCATCAAGCTCAACACAAAAAGGTGAAACCCTTGATGATACAGGT
AGAATGATTGATCAATATGCTGATATTATCGTGATGCGTCACCCTAAACCACATAGTGTTGAAGAGTTCT
CTAAATATGTCAACTCTCCTGTGATAAATGCTGGCGATGGTGAAAATGAACATCCCACTCAGTCATTGGT
TGACTTATATACTATCTACTCTGAGAAAGGCTCTCTTGATAATCTAAAAGTTGGTTTCTTAGGAGATCTA
AAATATGGTCGTACGGTTCACTCACTAACCAATATCCTTGCTAAATATAACGCCTCGTTTAAATTTATAT
CTTCAAAAGAGCTACAGATTCCTAAGAAACTAAAAGATTTTATCATCAAAAATGGCAACTCTTTTATTGA
GTTAGATAAAGTTAGTGCCGATGTTTTAGAAGACTTAGATGTACTATATGTAACTCGCGTCCAGAGAGAA
AGGTTTCCTGATGAAGAAAGCTATCTAAAAAATAAAGATTTATGCTATTTAGATAGAAAGCATATTTCCC
CTAGAAGTAATTTTATAATTCTTCATCCTCTACCTAGAGTTGATGAGATGGATAGATCTATTGATGAGCT
TGAGTGTGCGAAATATTTTGAGCAAATCAAATATAGTATTCCGATTAGGATGACGCTATTGGCTTTATTA
GTAATATCCTA
Protein Sequence 
>gi|56708676|ref|YP_170572.1| aspartate carbamoyltransferase [Francisella tularensis subsp. tularensis SCHU S4] MLSFQKLLRGDQITKDDLFKLFHQADIYKNKLANSEPIKDLEGKILASLFFEPSTRTRFSFESAMNRLGGKVISLENGSSSSTQKGETLDDTGRMIDQYADIIVMRHPKPHSVEEFSKYVNSPVINAGDGENEHPTQSLVDLYTIYSEKGSLDNLKVGFLGDLKYGRTVHSLTNILAKYNASFKFISSKELQIPKKLKDFIIKNGNSFIELDKVSADVLEDLDVLYVTRVQRERFPDEESYLKNKDLCYLDRKHISPRSNFIILHPLPRVDEMDRSIDELECAKYFEQIKYSIPIRMTLLALLVIS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyrB mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0540F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].