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pyrF

Victor ID 643
Gene Name pyrF
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191652
NCBI Protein GI 56708661
Locus Tag FTT1648c
Protein Accession YP_170557.1
Other Database IDs UniProtKB-ID: Q5NEI5_FRATT
UniRef100: UniRef100_Q14FY8
UniRef90: UniRef90_Q14FY8
UniRef50: UniRef50_B2SEI1
UniParc: UPI000049C5C1
EMBL: AJ749949
EMBL-CDS: CAG46281.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG482834
OMA: TASDEMV
ProtClustDB: CLSK986396
Taxonomy ID 177416
Gene Starting Position 1713240
Gene Ending Position 1713884
Gene Strand (Orientation) -
Protein Name Orotidine 5'-phosphate decarboxylase
DNA Sequence 
>gi|56707187:1713240-1713884 Francisella tularensis subsp. tularensis Schu 4, complete genome
CTTAGCACTCAAACTCTTTTAGCTTCTCAACGATATTTTCAGCGCGTAATAGCGGCCTACCTACAATAAT
GTAATCAACGCCAAGCTCTTTGGCTTTTTTAGGGGTCAAAGCGTTAAAATGATCATCACTTAGATCACTC
TCAAGCCTTACACCTGGGACATATAGCTTGATTTTATCGCCAAATTTAGCTCTGACATCAGCAACTAAAT
GTGGATGACATATAAAGTTTTCCACACCTAAATCCACACATCTTTGAAATTTAGCAAGGCTATCTGCCTT
ATCAAAATTAGCATCACTACTAAGTGTAATCACAGCTAATGGTATAGCTTGAGTATCTGCCGTAAGGGCT
GCTTTTATCATCTCATCACTAGCAGTACCATGAAATGTAAAATATTTAAAATTTGGAATAGCTTTTGAAT
AATTTTCAATTGCAGTTTTAACTGTATTTGGGATATCGTGTAACTTAAAGTCTAGGAAAATATCTTTGTC
GCCTACTAGCTCATGAATTTCTTTAAAAGATAACGTTGAGCATAGAATATGACCAATCTTAACACAGTCA
ACATACTTTGATACAGCGGCTGTTTTCTCTAAATCTGACTTAGAGATACCATCTGCTGAGAACATTATTT
TCATTGAGTTTCTCA
Protein Sequence 
>gi|56708661|ref|YP_170557.1| orotidine 5'-phosphate decarboxylase [Francisella tularensis subsp. tularensis SCHU S4] MRNSMKIMFSADGISKSDLEKTAAVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPNTVKTAIENYSKAIPNFKYFTFHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSLAKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVRLESDLSDDHFNALTPKKAKELGVDYIIVGRPLLRAENIVEKLKEFEC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyrF mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0284F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].