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pyrH

Victor ID 642
Gene Name pyrH
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191650
NCBI Protein GI 56707468
Locus Tag FTT0315
Protein Accession YP_169364.1
Other Database IDs UniProtKB-ID: PYRH_FRATT
UniRef100: UniRef100_Q14JD0
UniRef90: UniRef90_Q14JD0
UniRef50: UniRef50_A7N9R6
UniParc: UPI000049C25D
EMBL: AJ749949
EMBL-CDS: CAG44948.1
RefSeq_NT: NC_006570.2
HSSP: P0A7E9
GenomeReviews: AJ749949_GR
HOGENOM: HBG497552
OMA: RHMEKGR
ProtClustDB: PRK14556
Taxonomy ID 177416
Gene Starting Position 330110
Gene Ending Position 330859
Gene Strand (Orientation) +
Protein Name uridylate kinase
DNA Sequence 
>gi|56707187:330110-330859 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGTCTAATGATTCGTCAGAATGTTCTCAAAAACTCCCTAAACTTAAGAGAATTCTTCTTAAGTTAAGT
GGAGAATCTTTATCTGCAGATCAGGGTTTTGGTATAAATGTTGAATCTGCTCAACCTATCATAAATCAGA
TTAAAACTCTTACTAATTTTGGTGTTGAGCTTGCTTTAGTGGTTGGCGGTGGTAATATTTTGCGTGGTGG
TAGAGCTAATTTTGGTAACAAAATTAGAAGAGCTACTGCTGACTCAATGGGGATGATTGCTACTATGATT
AATGCTTTAGCTCTTCGTGATATGCTTATTAGTGAAGGTGTTGATGCTGAGGTTTTTTCAGCAAAAGGAG
TGGATGGGTTGTTGAAAGTTGCTAGTGCGCATGAATTTAATCAAGAACTTGCCAAGGGTAGGGTTTTGAT
ATTTGCAGGTGGTACTGGTAACCCATTTGTAACAACTGATACTACTGCTAGTTTAAGAGCTGTTGAAATT
GGTGCTGATGCTTTGTTAAAGGCTACGACAGTTAATGGCGTGTATGATAAAGACCCAAACAAATATTCAG
ATGCTAAGCGTTTTGATAAAGTCACATTTTCAGAAGTGGTTAGTAAAGAACTTAATGTGATGGATTTGGG
AGCATTTACTCAGTGTAGAGATTTCGGTATTCCGATATATGTATTTGATTTAACTCAGCCTAACGCTTTA
GTTGATGCTGTTTTGGACTCAAAGTATGGTACTTGGGTTACTTTAGACTA
Protein Sequence 
>gi|56707468|ref|YP_169364.1| uridylate kinase [Francisella tularensis subsp. tularensis SCHU S4] MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRRATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAVEIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFGIPIYVFDLTQPNALVDAVLDSKYGTWVTLD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyrH mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0528F, under F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].