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relA

Victor ID 637
Gene Name relA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191632
NCBI Protein GI 56708546
Locus Tag FTT1508c
Protein Accession YP_170442.1
Other Database IDs UniProtKB-ID: Q5NEV0_FRATT
UniRef100: UniRef100_Q14GA3
UniRef90: UniRef90_Q14GA3
UniRef50: UniRef50_B2SEP9
UniParc: UPI000049C568
EMBL: AJ749949
EMBL-CDS: CAG46141.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG594146
OMA: DLGHRCR
ProtClustDB: CLSK935061
Taxonomy ID 177416
Gene Starting Position 1561698
Gene Ending Position 1563641
Gene Strand (Orientation) -
Protein Name GTP pyrophosphokinase
DNA Sequence 
>gi|56707187:1561698-1563641 Francisella tularensis subsp. tularensis Schu 4, complete genome
ATTAGCTGACCTCTTCATTATCATCCCAATTAACCTCTATAAATTTCTCAGGACTTTTTTCTTTGAGGTG
ATTTAGATTAGGACAGTTTGTAGTATGAATAACTACTCCTTTTGAAACACTCATATAACCTTGAATTTGA
TCAGGATAAACAGGATGGCAGCACTTAGCCATCTCATATTTCATACCATCAAAACCGGAAACTAAGACTT
TTGGGGCTTTGGCTTTTAAGTTTGTTACTTTATGCTTTTTCTTGATTAATTTCTCTTCTGCTGAATAAGT
ATCAATAATATAATTAACAACGCTATTAGTCTTTAAACTTCCACCCTCAATCGCTGCAAAAAGACTATCA
CTAGTTTTCATATTAAACTTAGCAGCAACTTCAACAAAATCGACCTCTTTAAGGTCATAACCTCTTAGCT
CTTTTAGAAGGCGATCTTTTCCTAAAGCTATATTATCTTCTTTATTCTGCTCATTAAACCATTTGGTGAC
TCTTGATCTATTCCGTGCAGAAGTTAAATAACCTAAATTTTCTGATGCCCAATCTTTACTTGGATTAGGT
TCTTTACCTGTTAGAATCTCAACTTTATCACCAGTCTTTAGCTTAGTTGTTAACGGTACTATCTTACCAT
TTAGTTTAGCGCCTTTAGTACGGTGACCAACCATAGTATGTACTGAGTAAGCAAAATCTAAGACTGTCGA
ACCTTCAGCTAAATCTATTAGCTCATTTGCTGGCGTAAATACATAAAGCTTTTTATTAAGCTCTTTTGTG
ATTTGACTATCATCTTCATTAATCTCTTTCTCCCATTCAAGAAGAGATCTTAACCAAGCAACCCTAGCCT
CATAAGAAGCATCAAATTTAACACCTTCCTTATAACGCCAATGTGCCGCAAAACCCAACTCAGATTCTTC
ATGCATTTGTTGGGTTCTAATTTGAACCTCAATATTCTGCTCGCCAACTTTGACAACTGTATGTATTGAT
TTGTAACCATTTGGCTTAGGGTGAGCAATATAATCACTAAATTCTTCAGGTATTGGTGAATATAAATTAT
TAACCTCAGCAAGTACTTTATAACACTCATCAACATTATTTGTGATAACCCTAACAGCTGTAATATCATA
TAAATCATCAAGTTCTTGGTAACCTTTATTCTTAAACTTCTTGTAGATACTATAGATATGCTTAACTCTA
CCTTGAATACCAGCATGTAAGTTGTATTTTTTGAGCGTTGACTTTAATTCCTGGATTACTTGATGCAGGA
AATCTTCACGCTGTTTTCGCGTCACACCTAAACTTTTAGCTATTCGTTTGTATTCATCTTGCTGTAAAAA
GAAAAATGCTCTATCTTCTAGCTCCCATTTGATGGCACCTAAGCCAAGTCTATTTGCCAATGGCGCATAG
ATATCTAATGTTTCCCTAGCAATAACTCGTTGGGTATTACTACTTAGAGATTTTAAATGGCGAATTGTAC
ACAGTTTGTCGACAATCTTTACTAAAACAATTCTGACATCTTCAATAATTGTCAATAGCATTTTCCTAAA
TATATCAATTTGCTCTAAGGAAATATTATCTGAGCGATACATTCTAATAGCAGACATTTTTCGCGTGCCT
TGTAAAATCTTAAGCACTGTTTGATTAGTAGCCTGCTCGATATCTTCATCAGATATATCACCAAAATTAT
ACAATTCATAAAGGATACCTGCAGAAACAGACTCTTCATCTGCTCTAATTTTGAAAAGTACATATGCCAT
CTCGATAGCATATAAAAATGAGCTAATACCTGTAGGGTGACGCACAGATTCAGCACTTTTATTCTTAAGT
AATTCTAGAGCTGCAGCTATAATCTCAAACTTGTCACTAGTATAAAAACTTTTAAGCTCAGATATCAAAA
GCTCATCTTTTATCTGACCATCACTATCTAGAAGTTTAGAGTCAATAACTTGCA
Protein Sequence 
>gi|56708546|ref|YP_170442.1| GTP pyrophosphokinase [Francisella tularensis subsp. tularensis SCHU S4] MQVIDSKLLDSDGQIKDELLISELKSFYTSDKFEIIAAALELLKNKSAESVRHPTGISSFLYAIEMAYVLFKIRADEESVSAGILYELYNFGDISDEDIEQATNQTVLKILQGTRKMSAIRMYRSDNISLEQIDIFRKMLLTIIEDVRIVLVKIVDKLCTIRHLKSLSSNTQRVIARETLDIYAPLANRLGLGAIKWELEDRAFFFLQQDEYKRIAKSLGVTRKQREDFLHQVIQELKSTLKKYNLHAGIQGRVKHIYSIYKKFKNKGYQELDDLYDITAVRVITNNVDECYKVLAEVNNLYSPIPEEFSDYIAHPKPNGYKSIHTVVKVGEQNIEVQIRTQQMHEESELGFAAHWRYKEGVKFDASYEARVAWLRSLLEWEKEINEDDSQITKELNKKLYVFTPANELIDLAEGSTVLDFAYSVHTMVGHRTKGAKLNGKIVPLTTKLKTGDKVEILTGKEPNPSKDWASENLGYLTSARNRSRVTKWFNEQNKEDNIALGKDRLLKELRGYDLKEVDFVEVAAKFNMKTSDSLFAAIEGGSLKTNSVVNYIIDTYSAEEKLIKKKHKVTNLKAKAPKVLVSGFDGMKYEMAKCCHPVYPDQIQGYMSVSKGVVIHTTNCPNLNHLKEKSPEKFIEVNWDDNEEVS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: relA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].