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ribA

Victor ID 636
Gene Name ribA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191626
NCBI Protein GI 56708683
Locus Tag FTT1673
Protein Accession YP_170579.1
Other Database IDs UniProtKB-ID: Q5NEG3_FRATT
UniRef100: UniRef100_Q14FW6
UniRef90: UniRef90_Q14FW6
UniRef50: UniRef50_Q14FW6
UniParc: UPI000049C5D3
EMBL: AJ749949
EMBL-CDS: CAG46306.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG735778
OMA: NIVAREP
ProtClustDB: CLSK935133
Taxonomy ID 177416
Gene Starting Position 1742287
Gene Ending Position 1743498
Gene Strand (Orientation) +
Protein Name riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II
DNA Sequence 
>gi|56707187:1742287-1743498 Francisella tularensis subsp. tularensis Schu 4, complete genome
AATGTTTGAGCAAATAAAAAATAATGTTGAGAATGCCATAGAAGCTCTTAAGCAAGGCAAACCCGTAGTT
GTACTTGATGATTATGATAGAGAAAATGAGGGTGATCTAATTCTACCGGGTCAAAAAGCTACAGAAGAAA
ATATCGCATTTATGCTTGAGCATACAAGTGGCATCATTTGTTTGGCAATGGACTCAAAGAAAGCACGAGA
ATTAAATCTAACGCCAATGGTAGCTGCTGACCAAAACAATAGTACTTTTACAACTCCTTTTACTGTAACT
ATAGAGGCTAAAGAAGGGGTAACTACAGGAGTATCGGCAAAGGATAGAGCACATACTATTCAAGTTGCAT
CAAAAGCTGATTCTAAAGCAGAAGAATTAGCTAGACCTGGACATATATTCCCTCTTATAGCCAATGATAA
AGGCGTACTTGGTAGAAATGGTCATACTGAGGCAACTGTTGATCTTATGAAACTAAGTGGTTTTAATAGC
GCTGGAGTTCTATGTGAGCTAATGAATAAAGATGGCACCATGATGAAAGCTGCTGAACTAGAAGCATTTG
CTAAAAAGCACGATCTGCCTCTTTTAACTATTGCAGAGCTTTACCAATATCGTTTAGCAACTGAAAATTT
TGTCACGAAAATGGCAAGCTCTACTATACCATTCAAGAAAATTGGCGAATTGGAAATGAGTGTGTATAAA
GATAACTTTAGTGGTGATGAAGTTGTTGTTTTATCTAAACCTTATTCTGGTAATAATCCTTTAGTAAGAA
TGCATTCATCTTGCATAACAGGAGATATTTTTGGCTCGCTACGCTGTGACTGCCAAGATCAATTACATAA
AGGAATTGAAATGATTAGCGAAGAGGGTGGCTTTTTTATATATCTTGACCAAGAAGGTAGAGGTATTGGT
TTAACAAATAAGCTTAAAGCCTATAATTTGCAGATGAATGAAAATATGGACACTCTTGAAGCTAATTTAG
CTCTTGGCTTACCCGCTGACGCAAGAAAATACGATCTAGCTATACAAGTCCTAAAATATAACAATGTCAA
CCGCTGCCGATTAATATCTAATAATCCTGAAAAGCTAGCTGCTCTTAGAAACGTTGATATAGAAACACAA
CCAGTATATTGTGAGGCATTTGTAAACTCTCACAATAGAAACTACTTGATAACTAAAAAAATTAAAGCAA
AACATACAATTAAAGGAATATA
Protein Sequence 
>gi|56708683|ref|YP_170579.1| riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II [Francisella tularensis subsp. tularensis SCHU S4] MFEQIKNNVENAIEALKQGKPVVVLDDYDRENEGDLILPGQKATEENIAFMLEHTSGIICLAMDSKKARELNLTPMVAADQNNSTFTTPFTVTIEAKEGVTTGVSAKDRAHTIQVASKADSKAEELARPGHIFPLIANDKGVLGRNGHTEATVDLMKLSGFNSAGVLCELMNKDGTMMKAAELEAFAKKHDLPLLTIAELYQYRLATENFVTKMASSTIPFKKIGELEMSVYKDNFSGDEVVVLSKPYSGNNPLVRMHSSCITGDIFGSLRCDCQDQLHKGIEMISEEGGFFIYLDQEGRGIGLTNKLKAYNLQMNENMDTLEANLALGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDIETQPVYCEAFVNSHNRNYLITKKIKAKHTIKGI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ribA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0108H, under H: Coenzyme transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].