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FTT1258

Victor ID 618
Gene Name FTT1258
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191474
NCBI Protein GI 56708320
Locus Tag FTT1258
Protein Accession YP_170216.1
Other Database IDs UniProtKB-ID: Q5NFH6_FRATT
UniRef100: UniRef100_A4IXC2
UniRef90: UniRef90_A7NB48
UniRef50: UniRef50_A7NB48
UniParc: UPI000049C4D3
EMBL: AJ749949
EMBL-CDS: CAG45891.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG482448
OMA: VKAPALW
ProtClustDB: CLSK934926
Taxonomy ID 177416
Gene Starting Position 1280069
Gene Ending Position 1281541
Gene Strand (Orientation) +
Protein Name outer membrane efflux protein
DNA Sequence 
>gi|56707187:1280069-1281541 Francisella tularensis subsp. tularensis Schu 4, complete genome
AATGATACGAAATAAAATACTTCCTTTAGCGTTAATATCAGCAACCTTAATAACATCTAGCTGTAGCTTC
TTTAGCCCTGAGTATGAAAGACCTAAAATCAAAGCTCCAGCTTTATGGAATAACCAAGATAAAAATATTG
AAGTTACAAAAAACTGGGACCTTACGAAAGTTGCATGGTGGAGAGAGTTTAATGACCCAGTATTAAATAA
TCTAATAACTACTGCCTTAAAAGATAATAACAAATTACAAGTTTCTATTGGTAATATCCTACAAGCTAAT
GCTGAGATAAATAAAGCCAACTATGGCTGGTTACCTACCGCGAGTGTTGGTGGTGGTGGTTTTGTGGCAC
AGGCATTTGATGTTAACTCCAACTCAAATATCCCTCAGCTTAATAATATTGGCACTCAAACTACCGCAGG
ATCTTTGGTTGGTATTATACCTAGCTATACAATCAATATCGCTAGACAGTTTAAATTAGGTGAGATTTCA
CGTCTTAGCAAAAAAATGCAAACTAACCTTAAAGATACCACAAGACTATCAATTATAAGCCAAGTTAGTG
CTGCATATTTTTCACTGATTACAGCAAAAGAGCAATTAAAATTACAAACGTTAATGGTTAATCAGCTGAA
CTTGATGTTTAAGTACGCACAAAACCAACATAAACTCGGCGCCACCTCGCCAATGCTTGAAGAAGTTATT
AGACAACAACTTGAGGTGCAAAAAGGTAAAATAGCTATGATCAAAAATGACATAGTTCATTTCCAAAATA
CTCTCAAAATATTAATGGGAAGAAACCCTGGTAAAATTGTCACAAGTAGAACTCTAAATGAAATTAATGC
TAATATAAAAGTTCCTATAAATATGCCTTCTCAAGTTTTAGAGAATAGACCAGATATTGGTATTGCTGAG
TACAAGCTTGAAACAGCAAATGCGAATATCGGTTTAGCTAGATCACAGTTTTTCCCAAGTATTGACCTTA
CTGGCACCTTTGGAAACGCTACACTTGCTCTTGGAGAACTTGCTACAATGAATGCTTGGGCTTGGGCTGC
TGAAGCTGTTGCTGCTGTACCAGTATTTAATCTAAGTATTTTAGCTGATAGTGATAAGGCTAAAGCACAG
TTTTATCAAGCATATTACGATTATATTAATACGCTACAACAAGCTTTCCAAGATGTTGATGATAGCCTTT
CTGAAAGAGCTGCTAATGCAAAAAATCTTAAAAAACAAACTATATCTTTAGAATCCACTCAAAGGCAAGA
GAAAATATTCTTTAAAAAGTATAGTTCTGGGGCTATAAGTAAAGCACAATATACAGGTATTACATTGAAT
GTACTATATCAACAAATGCAAGTTAACCAAGCTAAATTGAAATCTTTGATTAGTGTAGTTAATTTGTACC
AAGCTCTTGGTAGTGGCTATAATGTTGATAATTATGTTGATCCTCATTATGATAACCCAGCTTTTGATAA
ATA
Protein Sequence 
>gi|56708320|ref|YP_170216.1| outer membrane efflux protein [Francisella tularensis subsp. tularensis SCHU S4] MIRNKILPLALISATLITSSCSFFSPEYERPKIKAPALWNNQDKNIEVTKNWDLTKVAWWREFNDPVLNNLITTALKDNNKLQVSIGNILQANAEINKANYGWLPTASVGGGGFVAQAFDVNSNSNIPQLNNIGTQTTAGSLVGIIPSYTINIARQFKLGEISRLSKKMQTNLKDTTRLSIISQVSAAYFSLITAKEQLKLQTLMVNQLNLMFKYAQNQHKLGATSPMLEEVIRQQLEVQKGKIAMIKNDIVHFQNTLKILMGRNPGKIVTSRTLNEINANIKVPINMPSQVLENRPDIGIAEYKLETANANIGLARSQFFPSIDLTGTFGNATLALGELATMNAWAWAAEAVAAVPVFNLSILADSDKAKAQFYQAYYDYINTLQQAFQDVDDSLSERAANAKNLKKQTISLESTQRQEKIFFKKYSSGAISKAQYTGITLNVLYQQMQVNQAKLKSLISVVNLYQALGSGYNVDNYVDPHYDNPAFDK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: FTT1258 mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG1538MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].