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prfC

Victor ID 592
Gene Name prfC
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191238
NCBI Protein GI 56707292
Locus Tag FTT0118
Protein Accession YP_169188.1
Other Database IDs UniProtKB-ID: RF3_FRATT
UniRef100: UniRef100_Q14JV7
UniRef90: UniRef90_B0TWY6
UniRef50: UniRef50_Q5P409
UniParc: UPI000049C1DC
EMBL: AJ749949
EMBL-CDS: CAG44751.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG285678
OMA: LQFEVVQ
ProtClustDB: PRK00741
Taxonomy ID 177416
Gene Starting Position 126898
Gene Ending Position 128475
Gene Strand (Orientation) +
Protein Name peptide chain release factor 3
DNA Sequence 
>gi|56707187:126898-128475 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGAGTGAATATCTACAACAAATCGCTAAGCGTAGGACTTTTGCAATTATTTCTCACCCAGATGCTGGT
AAGACAACAATTACAGAAAAAATGTTACTTTTTGGTAATGCTATCAAGACAGCAGGAACTGTTAAAGCTA
AAAAAAGTGGTATACATGCTACATCGGATTGGATGGAGATGGAGAAACAAAGAGGAATTTCAATCACAAC
CTCGGTAATGCAATTTCCCTATAATGGACGTATTATAAATCTACTTGATACTCCAGGACATGAAGATTTC
TCTGAGGATACTTATAGAACACTTACTGCGGTAGATTCAGCACTAATGGTTGTTGATGCAGTTAAAGGTG
TCGAGGATAGGACTATTAAGCTGATGAATGTTTGTCGCTTAAGAGATACGCCTATTGTAACTTTTATGAA
TAAGTTTGATCGAGATACTCGTGATCCTCTTGAGCTTTTAGATGAAGTTGAGAATATCCTTAAGATAAAA
TGTGCTCCAATAAATTGGCCAATTGGTATGGGTAAATATTTTAAAGGAGTTTACGATTTGTATAATGATG
AAGTTACTCTATTTGAAACAGGTCATGGGCACGAGATATATCCATACAAAAAGATCAAAGGTCTAGCAAA
TGCTAAAGATGCTATAGGCATAGACCTCTATGAAGATCTTGAGATGGAAATTGATTTAGTGCGTGGCGCA
AGTCATGAGTTTGATGAGCAGGAATTTCTAGAGGGCAATCTCACTCCAGTATATTTTGGTACTGCACTGA
GTAATTTTGGTGTCAAAGAAATGATGGATGGTTTTACAAGGTACGCTCCAGCACCCCAGCATCGCGAAGC
TGATCAAAGAGTTGTTGCTGCAGACGAGCAAAAATTGACAGGTTTTGTATTTAAAATACAAGCAAATATG
GATGAAAAACATCGCAATAGAATTGCATTTTTTAGAATTTGTTCTGGCAAGTATGAAAAAGGTATGAAAA
TTTTTCATGAAAGAACCGGTAAGCAAATGCAAATCTCAAAAGCACTAACTTTCATGGCAGGTGAAAGAGA
GCAAGTTGAAGAAGGTTATGCTGGGGATATTATTGGTTTACATAATCATGGTAGTATTCAGATTGGCGAT
AGTTTTACTCAAGGAGAAAAACTAAAATTCAAAGGCATACCAAATTTTGCTCCTGAGATTTTCAAAAGAG
TTAAACTAAATGATCCACTAAAAATGAAAGCATTACAAAAAGGTTTAGTGCAGCTATCAGAAGAAGGCGC
TACACAAGTTTTCAAACCTTTTATATCGAATGATTTGGTACTTGGAGCTGTTGGTGTTTTGCAGTTTGAT
GTGGTTGCACAGCGTTTGGCATCAGAGTACAATGTCAAATGTTCGTACGAGGGAGTGAACGTTACCTTAG
CACGTTGGATTTTTTGTAATGATGAGAAAAAGCTTAATGATTTTAAGAAAAAGTATGAGGTGAATTTGGC
TTATGATGGGGCAGGGTATCTTACATATCTAGCGCCAACAGGGGTTAATTTACAGCTGGCACAAGAAAAA
AATCCAGATATCATATTTAGTGCAACAAGAGAGCACTA
Protein Sequence 
>gi|56707292|ref|YP_169188.1| peptide chain release factor 3 [Francisella tularensis subsp. tularensis SCHU S4] MSEYLQQIAKRRTFAIISHPDAGKTTITEKMLLFGNAIKTAGTVKAKKSGIHATSDWMEMEKQRGISITTSVMQFPYNGRIINLLDTPGHEDFSEDTYRTLTAVDSALMVVDAVKGVEDRTIKLMNVCRLRDTPIVTFMNKFDRDTRDPLELLDEVENILKIKCAPINWPIGMGKYFKGVYDLYNDEVTLFETGHGHEIYPYKKIKGLANAKDAIGIDLYEDLEMEIDLVRGASHEFDEQEFLEGNLTPVYFGTALSNFGVKEMMDGFTRYAPAPQHREADQRVVAADEQKLTGFVFKIQANMDEKHRNRIAFFRICSGKYEKGMKIFHERTGKQMQISKALTFMAGEREQVEEGYAGDIIGLHNHGSIQIGDSFTQGEKLKFKGIPNFAPEIFKRVKLNDPLKMKALQKGLVQLSEEGATQVFKPFISNDLVLGAVGVLQFDVVAQRLASEYNVKCSYEGVNVTLARWIFCNDEKKLNDFKKKYEVNLAYDGAGYLTYLAPTGVNLQLAQEKNPDIIFSATREH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: prfC mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG4108J, under J: Translation, ribosomal structure and biogenesis
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].