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carA

Victor ID 582
Gene Name carA
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3191074
NCBI Protein GI 56708674
Locus Tag FTT1663
Protein Accession YP_170570.1
Other Database IDs UniProtKB-ID: Q5NEH2_FRATT
UniRef100: UniRef100_A4J095
UniRef90: UniRef90_A4J095
UniRef50: UniRef50_B0TWB9
UniParc: UPI000049C5CC
EMBL: AJ749949
EMBL-CDS: CAG46296.1
RefSeq_NT: NC_006570.2
GenomeReviews: AJ749949_GR
HOGENOM: HBG286341
OMA: EADIPFF
ProtClustDB: PRK12564
Taxonomy ID 177416
Gene Starting Position 1729091
Gene Ending Position 1730257
Gene Strand (Orientation) +
Protein Name carbamoyl phosphate synthase small subunit
DNA Sequence 
>gi|56707187:1729091-1730257 Francisella tularensis subsp. tularensis Schu 4, complete genome
TATGATATTAGCTAACGATATGACTAATGCGATATTGGTTTTCCCAGATGGTACATACTATCTAGGTAGA
TCAATAGGGGTTCGTGGTTGGACAGACGGCGAAATTTGTTTCAATACATCAATGACAGGTTACCAAGAGA
CTCTAACAGATCCATCTTATGCTGGTCAGATTATAACTTTTACATTCCCACACATAGGTAATGTCGGTAT
CAATAATGAGGATAATGAATCACTTGGTGTATTTGCTAAAGGTCTAATCGTACGTGAGAACCTTACAAAC
CCATCAAATTTTAGAGCTAAAAAGCATATAGATACATGGCTAAAAAATAGAAATATAGTCGGTATCTGTG
GTGTTGATACGCGTGCAATCGTACGTAAAGTGCGTAAAGAAGGCGCGGTAAGAGTTGCTATACTTTCGGT
CAAACCAGGTGAGTTTTTGGATGCAAACTATGTCAGATCGCGTATCAAAAATAAATCTAACCTAAATGGT
AGAGATCTAGCTATCAGTGTGACTACAAACAGAGAATATGACTGGAATGAGCATACTTTCACACTAGGTC
AACAAGTATACAAACAGCAACAAAGCTACAAATATAGTGTTGTAGTTATCGATTATGGTGTCAAGTACAA
TATCTTAAGAAACCTAGTAGATGCTGGTTTTAAGGTAACTGTAGTACCTGCTGATAGTACTTATGAAGAT
ATTATGAAGCATAACCCTGATGGGGTGTTTTTATCAAATGGTCCTGGAGATCCATTTGCTACCTCTGACT
ATACTATGCCTGTTATCAAAAAGCTTCTAGAAGTCAAAATGCCAATATTTGGTATCTGTCTGGGTAACCA
ATTATTAGCCCTAGCTGCTGGTCTAAAAACTAAAAAAATGCATAAAGGTCACCGTGGTGTAAACCAACCA
GTACTTGATGCCAATACTAAAAAAGTTCTTATTACAAGCCAAAACCATGGCTTTGTGGTTTGTGATGATA
ATGTTCCTGATAATATTCAAATTCATATGAGCTCACTTTTTGATGGTACTGTTGAGGGATTACGATTTAA
AGACAGGCCAGCATTTGCCGTGCAGTACCACCCAGAGAGCTCACCAGGTCCGCATGACTGTAAGTATTTG
TTTAATGAATTTGCCGAGATGATAGCAGAAAGTAAGAAAGGGAATTA
Protein Sequence 
>gi|56708674|ref|YP_170570.1| carbamoyl phosphate synthase small subunit [Francisella tularensis subsp. tularensis SCHU S4] MILANDMTNAILVFPDGTYYLGRSIGVRGWTDGEICFNTSMTGYQETLTDPSYAGQIITFTFPHIGNVGINNEDNESLGVFAKGLIVRENLTNPSNFRAKKHIDTWLKNRNIVGICGVDTRAIVRKVRKEGAVRVAILSVKPGEFLDANYVRSRIKNKSNLNGRDLAISVTTNREYDWNEHTFTLGQQVYKQQQSYKYSVVVIDYGVKYNILRNLVDAGFKVTVVPADSTYEDIMKHNPDGVFLSNGPGDPFATSDYTMPVIKKLLEVKMPIFGICLGNQLLALAAGLKTKKMHKGHRGVNQPVLDANTKKVLITSQNHGFVVCDDNVPDNIQIHMSSLFDGTVEGLRFKDRPAFAVQYHPESSPGPHDCKYLFNEFAEMIAESKKGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: carA mutant is attenuated in mouse spleen (Weiss et al., 2007).
COG COG0505EF, under E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism
References
Weiss et al., 2007: Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(14); 6037-6042. [PubMed: 17389372].